CAS No. 58-60-6

Batch: Purity:99.91
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Puromycin aminonucleoside Chemical Structure
Chemical Structure
Check the Puromycin aminonucleoside product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3R,4S,5S)-4-amino-2-[6-(dimethylamino)purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol
CAS Number 58-60-6
Molecular Formula

C12H18N6O3
Molecular Weight (MW) 294.31
InChIKey RYSMHWILUNYBFW-GRIPGOBMSA-N

Ordering Information

Biological Activity

Puromycin aminonucleoside is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase. It disrupts renal cellular homeostasis and induces apoptosis in mesangial cells and podocytes, which is accompanied by reduced cell viability and an elevated inflammatory response. Consequently, this aminonucleoside derivative is widely utilized to establish experimental animal models of kidney disease, such as nephrotic syndrome and podocyte injury. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 59 mg/mL (200.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 30 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.