CAS No. 483367-10-8
Batch:
Purity:99.97
Chemical Structure
Check the
Purmorphamine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine | |
|---|---|---|
| CAS Number | 483367-10-8 | |
| Molecular Formula |
C31H32N6O2 |
|
| Molecular Weight (MW) | 520.62 | |
| SMILES | C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7 | |
| InChIKey | FYBHCRQFSFYWPY-UHFFFAOYSA-N |
Purmorphamine is a small-molecule Hedgehog pathway agonist that directly binds and activates Smoothened (Smo), competing against BODIPY-cyclopamine binding to Smo with an IC50 of ~. Downstream activation of Smo via purmorphamine stimulates Hedgehog target gene expression, driving cell differentiation and inducing osteogenesis in multipotent mesenchymal progenitor cells with an EC50 of ~1 μM. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
4 mg/mL
(7.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(96.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(96.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Purmorphamine Mechanism of Action: Smoothened (Smo) Activation in Pluripotent Stem Cell Research
- Purmorphamine Working Concentration | Cell Culture | Treatment
- Purmorphamine Solubility in DMSO
- Purmorphamine Stock Solution
- Purmorphamine Storage
- Purmorphamine Stability
- Purmorphamine Combination Database
- Purmorphamine Molecular Weight
- Purmorphamine SMILES
- Purmorphamine Chemical Structure (2D and 3D)
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Note: Technical data last updated: Sep 1, 2026.