CAS No. 82508-32-5
Batch:
Purity:99.78
Chemical Structure
Check the
Pseudolaric Acid A
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2E,4E)-5-[(1R,7S,8S,9R)-7-acetyloxy-4,9-dimethyl-11-oxo-10-oxatricyclo[6.3.2.01,7]tridec-3-en-9-yl]-2-methylpenta-2,4-dienoic acid | |
|---|---|---|
| CAS Number | 82508-32-5 | |
| Molecular Formula |
C22H28O6 |
|
| Molecular Weight (MW) | 388.45 | |
| InChIKey | GOHMRMDXUXWCDQ-MPVZDDSSSA-N |
Pseudolaric acid A is a natural diterpene that acts as a heat shock protein 90 (Hsp90) inhibitor with potent antiproliferative activity. By directly binding to Hsp90, Pseudolaric acid A induces cell cycle arrest at the G2/M phase and promotes cell death through the caspase-8/caspase-3 signaling pathway. These cellular effects mediate its downstream antiproliferative and anticancer phenotypes across various human cancer cell lines. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(200.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.