CAS No. 179474-85-2

Batch: Purity:99.89
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Prucalopride Succinate Chemical Structure
Chemical Structure
Check the Prucalopride Succinate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 179474-85-2
Molecular Formula

C18H26ClN3O3.C4H6O4
Molecular Weight (MW) 485.96
SMILES COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O

Ordering Information

Biological Activity

Prucalopride Succinate is a selective, high-affinity 5-HT4 receptor agonist targeting the human 5-HT4a receptor and human 5-HT4b receptor. Agonism of 5-HT4 receptors stimulates adenylate cyclase activity, increasing intracellular cAMP levels and enhancing enteric acetylcholine release. This signaling cascade promotes gastrointestinal motility and prokinetic phenotypes without affecting other monoaminergic receptors. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 97 mg/mL (199.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 97 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.