Clinical Trials

Propranolol has been evaluated in numerous clinical trials spanning Early Phase 1 through Phase 4 across diverse therapeutic areas. Sponsored by major academic institutions and hospitals, these studies target indications such as supraventricular tachycardia, spinal hemangiomas, severe burns, post-traumatic stress disorder, and ovarian carcinoma. Featuring varied recruitment statuses ranging from active to completed or terminated, this landscape reflects broad interest in repurposing propranolol across systemic, psychiatric, and oncological disorders.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07655440 NOT_YET_RECRUITING
Migraine Associated Vertigo; Tinnitus; Migraine; Vestibular Migraine
Stanford University
 2026-07 PHASE4
NCT04713657 RECRUITING
Tetralogy of Fallot; Double Outlet Right Ventricle
Weill Medical College of Cornell University
 2022-12-16 PHASE1
NCT07792122 NOT_YET_RECRUITING
Post-Traumatic Stress Disorder, PTSD
University Hospital, Toulouse
 2026-09 PHASE3
NCT00262470 ACTIVE_NOT_RECRUITING
Tachycardia; Chronic Orthostatic Intolerance
Satish R. Raj
 1997-04 PHASE1; PHASE2
NCT06670976 WITHDRAWN
Soft Tissue Sarcoma
Roswell Park Cancer Institute
 2026-05-15 PHASE1
NCT04682158 RECRUITING
Esophageal Adenocarcinoma
Roswell Park Cancer Institute
 2021-04-01 PHASE2
NCT05797662 NOT_YET_RECRUITING
Kaposi Sarcoma
AIDS Malignancy Consortium
 2026-09 PHASE2
NCT05651594 RECRUITING
Clinical Stage II Esophageal Adenocarcinoma AJCC v8; Clinical Stage III Esophageal Adenocarcinoma AJCC v8; Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage IV Esophageal Adenocarcinoma AJCC v8; Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8; Locally Advanced Esophageal Adenocarcinoma; Locally Advanced Gastroesophageal Junction Adenocarcinoma; Metastatic Esophageal Adenocarcinoma; Metastatic Gastroesophageal Junction Adenocarcinoma; Unresectable Esophageal Adenocarcinoma; Unresectable Gastroesophageal Junction Adenocarcinoma
Roswell Park Cancer Institute
 2023-03-07 PHASE2
NCT06972056 RECRUITING
Migraine
Mayo Clinic
 2025-07-09 PHASE4
NCT03083431 RECRUITING
Retinopathy of Prematurity
University of Zurich
 2022-09-22 PHASE2
NCT07353294 ENROLLING_BY_INVITATION
Bladder Urothelial Carcinoma; Lymph Node Metastasis
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2026-01-01 PHASE1
NCT07091279 RECRUITING
Autism Spectrum Disorder; Challenging Behaviour; Aggression; Severe Disruptive Behaviour Disorders; Self-injury
Jeremy Veenstra-vanderweele
 2026-01-30 PHASE2
NCT06833320 SUSPENDED
Postoperative Chylothorax; Congenital Heart Disease; Open Heart Surgery; Chylothorax
June Wu
 2025-09-09 PHASE1; PHASE2
NCT07311915 NOT_YET_RECRUITING
Prostate Cancer
Zhongda Hospital
 2026-01-15
NCT07074756 RECRUITING
Glioma; Recurrent Glioma; Recurrent Glioblastoma
Mayo Clinic
 2025-09-12
NCT05741164 RECRUITING
Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Triple-Negative Breast Carcinoma; Refractory Triple-Negative Breast Carcinoma; Unresectable Triple-Negative Breast Carcinoma
Emory University
 2024-09-01 PHASE2
NCT07583134 NOT_YET_RECRUITING
Breast Cancer; Myocardial Injury After Noncardiac Surgery (MINS)
Chang-Ik Yoon
 2026-05-26 PHASE4
NCT07568574 ENROLLING_BY_INVITATION
Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes
Enhanced Emirates Limited
 2026-03-12
NCT06445166 RECRUITING
Kaposi Sarcoma
Washington University School of Medicine
 2025-08-20 PHASE2
NCT05961761 RECRUITING
Soft Tissue Sarcoma Adult; Angiosarcoma; Undifferentiated Pleomorphic Sarcoma
Niels Junker
 2021-08-17 PHASE2
NCT07665177 NOT_YET_RECRUITING
Infantile Hemangioma (IH)
West China Hospital
 2026-07-01 PHASE4
NCT06719804 NOT_YET_RECRUITING
Epilepsy, Drug Resistant
Xuanwu Hospital, Beijing
 2024-12-05 EARLY_PHASE1
NCT05997732 RECRUITING
Vasoconstriction; Vasodilation
University of Alberta
 2023-10-31 PHASE4
NCT07452978 NOT_YET_RECRUITING
PTSD - Post Traumatic Stress Disorder
University Hospital, Tours
 2026-09-01 PHASE2
NCT04985344 RECRUITING
PTSD
University Hospital, Toulouse
 2023-02-01 PHASE3
NCT03588754 SUSPENDED
Alcohol Drinking
Yale University
 2018-09-15 PHASE2
NCT05219799 RECRUITING
Obesity; Vasodilation; Healthy
University of Missouri-Columbia
 2023-03-14 EARLY_PHASE1
NCT07652203 NOT_YET_RECRUITING
Cirrhosis
General Hospital of Shenyang Military Region
 2026-06
NCT07727993 NOT_YET_RECRUITING
Gastric or Gastroesophageal Junction Adenocarcinoma; Propranolol; SOX Chemotherapy; Toripalimab
Ting Liu
 2026-08-01 PHASE1; PHASE2
NCT05312255 RECRUITING
Plasma Cell Myeloma; Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma; Smoldering Plasma Cell Myeloma
Roswell Park Cancer Institute
 2022-06-28
NCT05429970 RECRUITING
Ovarian Cancer; Ovarian Carcinoma; Stage II Ovary Cancer; Stage II Ovarian Cancer; Stage III Ovary Cancer; Stage III Ovarian Cancer; Stage IV Ovary Cancer; Stage IV Ovarian Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Stage II Fallopian Tube Cancer; Stage III Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Primary Peritoneal Carcinoma
Memorial Sloan Kettering Cancer Center
 2022-06-17
NCT03384836 SUSPENDED
Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7
Roswell Park Cancer Institute
 2018-01-31 PHASE1; PHASE2
NCT06120140 ACTIVE_NOT_RECRUITING
Carcinoma, Non-Small-Cell Lung
Janssen Research & Development, LLC
 2024-02-16 PHASE2
NCT05587361 RECRUITING
Tobacco Use Disorder; Nicotine Dependence; Cigarette Smoking
University of Oklahoma
 2024-11-26 PHASE4
NCT07655700 NOT_YET_RECRUITING
Migraine Prophylaxis
Chittagong Medical College
 2026-07-01 PHASE4
NCT03919461 RECRUITING
Colorectal Neoplasms
Assaf-Harofeh Medical Center
 2019-02-28 PHASE2
NCT06145074 RECRUITING
Pancreatic Cancer; Surgery
Zealand University Hospital
 2024-03-20 PHASE2
NCT06775080 RECRUITING
Gastrointestinal Tumors
Huashan Hospital
 2024-12-01 PHASE2
NCT07271485 RECRUITING
Misophonia; Propanolol; Misophonia Treatment
Bloom Mental Health, LLC
 2025-12-19 EARLY_PHASE1
NCT07743255 ENROLLING_BY_INVITATION
Migraine Disorders
Nishtar Medical University
 2026-06-10
NCT06787066 RECRUITING
Menopause
University of Missouri-Columbia
 2025-07-10 EARLY_PHASE1
NCT01988883 ACTIVE_NOT_RECRUITING
Postural Tachycardia Syndrome
Vanderbilt University Medical Center
 2014-10 EARLY_PHASE1
NCT06499116 NOT_YET_RECRUITING
Migraine
Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
 2024-10 PHASE4
NCT06066710 RECRUITING
Aphasia, Primary Progressive
University of Missouri-Columbia
 2025-01-13 EARLY_PHASE1
NCT05424016 RECRUITING
Hemangioblastoma of CNS; Von Hippel-Lindau Disease
Assistance Publique - Hôpitaux de Paris
 2023-01-16
NCT05451043 RECRUITING
Pancreatic Cancer; Hepatocellular Cancer; Biliary Tract Cancer; Cholangiocarcinoma
AHS Cancer Control Alberta
 2023-07-05 PHASE2
NCT07528235 NOT_YET_RECRUITING
Intracerebral Hemorrhage; Stroke-Associated Pneumonia (SAP)
Tang-Du Hospital
 2026-05-01 PHASE1
NCT07352228 ENROLLING_BY_INVITATION
Rebleeding of Portal Hypertension in Liver Cirrhosis; Propranolol; Carvedilol
Xijing Hospital
 2026-01-01 PHASE4
NCT05968690 RECRUITING
Advanced Melanoma
Sarah Weiss
 2023-09-11 PHASE1
NCT06982183 RECRUITING
Fear of Spiders; Acute Stress Reaction
Walter Reed Army Institute of Research (WRAIR)
 2025-05-27 PHASE4
NCT06839144 RECRUITING
Ovarian Cancer; Ovarian Cancer Metastatic Recurrent
Tel-Aviv Sourasky Medical Center
 2025-03-12 PHASE2
NCT07125391 RECRUITING
Ovarian Cancer
Bai-Rong Xia
 2025-06-20 PHASE2
NCT07549906 NOT_YET_RECRUITING
Colon Cancer (Stage II &Amp; III); Immunotherapy; Beta Blocker; Neoadjuvant Chemoimmunotherapy
Sun Yat-sen University
 2026-04-20 PHASE2
NCT05853627 RECRUITING
Stress Disorders, Post-Traumatic
Massachusetts General Hospital
 2023-06-15 PHASE4
NCT06417177 RECRUITING
Aging; Menopause; Hypoxia; Vasodilation
University of Missouri-Columbia
 2024-06-03 EARLY_PHASE1
NCT06798363 RECRUITING
Infantile Hemangioma
West China Hospital
 2025-05-02 PHASE2; PHASE3
NCT06263452 RECRUITING
Cardiovascular Disease
University of North Carolina, Chapel Hill
 2024-05-01 PHASE4
NCT07354126 RECRUITING
Migraine
Muhammad Aamir Latif
 2025-09-01
NCT07147972 NOT_YET_RECRUITING
Migraine; Nutraceuticals
Fayoum University
 2025-08-20 PHASE3
NCT07560332 COMPLETED
Infantile Hemangioma (IH)
Cairo University
 2025-01-01
NCT03838029 UNKNOWN
Pancreatic Neoplasms
Assaf-Harofeh Medical Center
 2019-11-20 PHASE2
NCT01298271 COMPLETED
Bleeding Gastric Varices; Liver Cirrhosis
Taipei Veterans General Hospital, Taiwan
 2010-04 PHASE4
NCT04186286 RECRUITING
Postural Tachycardia Syndrome
University of Calgary
 2021-02-01 PHASE2
NCT07067853 COMPLETED
Migraine
Indonesia University
 2025-09-01
NCT06960850 NOT_YET_RECRUITING
Propranolol; Labour Induction
Federal Teaching Hospital Abakaliki
 2025-06-01
NCT04848519 ACTIVE_NOT_RECRUITING
Locally Advanced Bladder Urothelial Carcinoma; Locally Advanced Renal Pelvis Urothelial Carcinoma; Locally Advanced Ureter Urothelial Carcinoma; Locally Advanced Urethral Urothelial Carcinoma; Locally Advanced Urothelial Carcinoma; Metastatic Bladder Urothelial Carcinoma; Metastatic Renal Pelvis Urothelial Carcinoma; Metastatic Ureter Urothelial Carcinoma; Metastatic Urethral Urothelial Carcinoma; Metastatic Urothelial Carcinoma; Stage IV Bladder Cancer AJCC v8; Stage IV Renal Pelvis Cancer AJCC v8; Stage IV Ureter Cancer AJCC v8; Stage IV Urethral Cancer AJCC v8
Emory University
 2021-05-20 PHASE2
NCT05561751 COMPLETED
Multiple Myeloma
GPCR Therapeutics, Inc.
 2023-02-13 PHASE2
NCT06422494 COMPLETED
Diabetes Mellitus, Type 1; Inflammation
Radboud University Medical Center
 2025-09-28
NCT06870370 NOT_YET_RECRUITING
Traumatic Brain Injury (TBI) Patients; Intracranial Pressure; Intensive Care Unit; Mortality
Tanta University
 2025-09-20 PHASE3
NCT05979818 RECRUITING
Non Small Cell Lung Cancer; Propranolol
Second Xiangya Hospital of Central South University
 2024-11-13 PHASE1
NCT05256069 COMPLETED
Vasodilation; Hypoxia
University of Missouri-Columbia
 2023-04-26 EARLY_PHASE1
NCT06836856 RECRUITING
TBI Traumatic Brain Injury
Mansoura University
 2025-01-20 PHASE1; PHASE2
NCT06262061 UNKNOWN
TBI (Traumatic Brain Injury)
London Health Sciences Centre
 2024-03 EARLY_PHASE1
NCT05479123 TERMINATED
Infantile Hemangioma
The University of Texas Health Science Center, Houston
 2022-06-23 PHASE4
NCT06361446 UNKNOWN
Migraine
Kafrelsheikh University
 2024-03-29 PHASE3
NCT05692271 COMPLETED
Stress Disorders, Post-Traumatic; Alcohol Use Disorder
Centre for Addiction and Mental Health
 2023-07-15 PHASE2
NCT04921982 WITHDRAWN
Post Traumatic Stress Disorder
Rennes University Hospital
 2024-10 PHASE2
NCT04950426 COMPLETED
Fibromyalgia Syndrome; Posttraumatic Stress Disorder
Centre Hospitalier Henri Laborit
 2021-08-13 PHASE2
NCT07104526 COMPLETED
Infantile Hemangioma (IH)
Wuhan Integrated Traditional Chinese and Western Medicine Hospital
 2024-01-01
NCT04508244 UNKNOWN
Trauma; Brain Injuries; Stress Reaction; Beta Blockers; Troponin
Hamad Medical Corporation
 2020-12-29 PHASE4
NCT06621004 ENROLLING_BY_INVITATION
Mean Arterial Pressure
Ain Shams University
 2024-08-25 EARLY_PHASE1
NCT05085782 COMPLETED
Chronic Low-back Pain; Fibromyalgia
Université de Sherbrooke
 2022-02-07 PHASE2
NCT05419193 COMPLETED
Stroke; Vascular Accident; Intracranial Hemorrhages; Intracerebral Hemorrhage; Hemorrhagic Stroke; Stroke, Acute
Beijing Tiantan Hospital
 2023-02-21 PHASE2; PHASE3
NCT07113015 COMPLETED
Parkinson Disease (PD); Tremor
Multan Medical And Dental College
 2024-07-05
NCT05651789 UNKNOWN
Portal Hypertension; Varice Bleed; Cirrhosis, Liver
West China Hospital
 2023-01
NCT05928689 COMPLETED
Misophonia
Icahn School of Medicine at Mount Sinai
 2023-06-02 EARLY_PHASE1
NCT06485726 UNKNOWN
Migraine Disorders
Kafrelsheikh University
 2023-01-23 PHASE4
NCT04406870 UNKNOWN
Hemangioendothelioma of Liver
Shanghai Children's Medical Center
 2020-07 PHASE4
NCT05375240 UNKNOWN
Stroke; Cerebrovascular Disorders; Ischemic Stroke; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Cardiovascular Diseases; Propranolol; Beta Blocker; Molecular Mechanisms of Pharmacological Action; Immunologic Factors; Physiological Effects of Drugs
Tianjin Medical University General Hospital
 2022-06 PHASE2
NCT03049306 COMPLETED
Obstructive Sleep Apnea
Johns Hopkins University
 2017-02-15 PHASE2
NCT06034158 UNKNOWN
Healthy
Sir Run Run Shaw Hospital
 2023-09-18
NCT01970748 UNKNOWN
Bleeding Esophageal Varices; Hepatocellular Carcinoma
Taipei Veterans General Hospital, Taiwan
 2009-08 PHASE4
NCT04982211 UNKNOWN
Trauma and Stressor Related Disorders; Post Traumatic Stress Disorder; Acute Stress Disorder; Adjustment Disorders
Douglas Mental Health University Institute
 2021-08-01 PHASE2
NCT05679193 COMPLETED
Prostate Cancer
Oslo University Hospital
 2023-01-02 PHASE2
NCT06158230 UNKNOWN
Migraine
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2023-03-19 PHASE2
NCT04518124 COMPLETED
Angiosarcoma
The Netherlands Cancer Institute
 2019-12-27 PHASE2
NCT04047355 COMPLETED
Autism Spectrum Disorder; Developmental Disability; Aggression; Self-Injurious Behavior; Challenging Behavior
Rutgers, The State University of New Jersey
 2021-02-11 PHASE2
NCT05427474 UNKNOWN
Traumatic Brain Injury
Zagazig University
 2022-12-01 PHASE3
NCT05805553 UNKNOWN
Arrest; Bone; Development; Growth
King Edward Medical University
 2020-12-01
NCT04493489 UNKNOWN
Bladder Cancer
Central South University
 2020-09-06 PHASE2
NCT06670690 COMPLETED
Intraoperative Bleeding
Menoufia University
 2023-09-01
NCT05189977 TERMINATED
Post-traumatic Stress Disorder (PTSD)
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2022-09-07 PHASE1
NCT05851781 COMPLETED
Migraine Disorders
Kafrelsheikh University
 2022-06-01 PHASE3
NCT06014606 COMPLETED
Motivation
Maastricht University
 2021-03-01
NCT05692869 COMPLETED
Healthy
Eli Lilly and Company
 2023-01-31
NCT05525416 COMPLETED
Vasodilation; Vasoconstriction
University of Alberta
 2022-07-28
NCT07180043 COMPLETED
Pediatric Migraine; Headache Disorders
Kayseri University
 2021-01-01
NCT01299753 UNKNOWN
Burns
Sunnybrook Health Sciences Centre
 2011-02
NCT01950520 COMPLETED
Healthy Volunteers
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2014-02-07 PHASE2
NCT05106179 UNKNOWN
Spinal Tumor; Spinal Hemangioma; Beta Blocker Toxicity
Center for Vascular Pathology, Moscow
 2021-12 PHASE4
NCT04467086 COMPLETED
Mechanical Ventilation; Sedation; Critical Illness; COVID
Ottawa Hospital Research Institute
 2021-01-08 PHASE3
NCT02428205 COMPLETED
Autism
University of Missouri-Columbia
 2015-04
NCT03434444 COMPLETED
Postpartum Hemorrhage
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2017-09-08
NCT04513509 COMPLETED
Atrial Fibrillation; Rate Control; Cardiopulmonary Exercise Test
National Taiwan University Hospital
 2020-10-21
NCT04299438 TERMINATED
Pregnancy, Prolonged
Lisa Levine
 2020-07-14 PHASE3
NCT04741698 COMPLETED
Labour;Obstructed; Labor Dystocia
Christiana Care Health Services
 2021-07-27 PHASE1
NCT04113187 TERMINATED
Hereditary Hemorrhagic Telangiectasia; Osler Weber Rendu Disease
University Hospital, Bordeaux
 2020-06-23 PHASE3
NCT03171805 UNKNOWN
Liver Cirrhoses; Portal Hypertension; Gastric Varix
West China Hospital
 2017-06-01
NCT05195996 COMPLETED
Trauma, Brain
Menoufia University
 2021-10-01 PHASE4
NCT03094234 UNKNOWN
Portal Hypertension
West China Hospital
 2017-04-28
NCT03152175 UNKNOWN
Trauma and Stressor Related Disorders; Post-traumatic Stress Disorders; Adjustment Disorders; Acute Stress Disorder
Douglas Mental Health University Institute
 2017-03-30 PHASE2
NCT03893617 TERMINATED
DNA Damage; Psychological Stress
Dana Bovbjerg
 2017-10-05 PHASE1
NCT01988831 SUSPENDED
Stages III Skin Melanoma; Stages II Skin Melanoma; Stage IB Skin Melanoma
University Hospital, Geneva
 2016-06 PHASE2
NCT04208776 COMPLETED
Decompensated Cirrhosis; Severe Ascites
Institute of Liver and Biliary Sciences, India
 2020-02-04
NCT04684667 UNKNOWN
Infantile Hemangioma
Assiut University
 2021-01-01 PHASE2
NCT02620579 COMPLETED
Shoulder Pain
Duke University
 2016-01 PHASE2
NCT03589014 COMPLETED
Cerebral Cavernous Malformation
Mario Negri Institute for Pharmacological Research
 2018-04-11 PHASE2
NCT02153944 COMPLETED
Anxiety Disorder
National Institute of Mental Health (NIMH)
 2014-06-16 PHASE4
NCT04421209 WITHDRAWN
Lumbar Disc Disease; Spinal Fusion; Degenerative Disc Disease
Duke University
 2020-12 PHASE2
NCT04833218 UNKNOWN
Traumatic Brain Injury
Minia University
 2020-01-31 EARLY_PHASE1
NCT03152786 TERMINATED
Prostate Carcinoma
Wake Forest University Health Sciences
 2019-01-15 PHASE2
NCT05251610 COMPLETED
Duration of Labor
Darlington-Peter Chibuzor Ugoji
 2020-11-02
NCT04682184 COMPLETED
Healthy
Eli Lilly and Company
 2021-01-27
NCT03474614 TERMINATED
Cerebral Cavernous Malformations
St. Joseph's Hospital and Medical Center, Phoenix
 2018-01-24 PHASE2
NCT04580342 UNKNOWN
Hypotension
Ahmed talaat ahmed aly
 2020-10-15 PHASE2
NCT03720067 UNKNOWN
Cirrhosis; Portal Hypertension; Variceal Hemorrhage
Universidade Federal do Rio de Janeiro
 2019-01-25 PHASE2; PHASE3
NCT04288700 UNKNOWN
Infantile Hemangioma
Ain Shams University
 2019-10-01 PHASE4
NCT00748059 COMPLETED
Autonomic Nervous System Diseases; Orthostatic Hypotension; Dopamine Beta-Hydroxylase Deficiency; Orthostatic Intolerance
Vanderbilt University Medical Center
 1996-12 PHASE1
NCT02790736 TERMINATED
Social Anxiety Disorder
New York State Psychiatric Institute
 2016-06 PHASE4
NCT02595996 TERMINATED
Primary Lymphedema
Columbia University
 2017-06-07 PHASE2
NCT03151681 COMPLETED
Adjustment Disorders; Posttraumatic Stress Disorder; Trauma and Stressor Related Disorders
Douglas Mental Health University Institute
 2015-11-01 PHASE2; PHASE3
NCT04533841 COMPLETED
Induction of Labor Affected Fetus / Newborn
Ahmed mohamed fathy ismail
 2020-02-01 PHASE2
NCT03245554 UNKNOWN
Gastrointestinal Cancer
Central South University
 2018-05-01 EARLY_PHASE1
NCT03633747 TERMINATED
Hemangioma Liver
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2018-07-01 PHASE1; PHASE2
NCT03108300 UNKNOWN
Malignant Soft Tissue Sarcoma
Ain Shams University
 2019-08-30 PHASE2
NCT01902966 TERMINATED
Cervical Cancer
M.D. Anderson Cancer Center
 2013-09-11
NCT02871349 COMPLETED
Autism Spectrum Disorder
University of Missouri-Columbia
 2016-08 EARLY_PHASE1
NCT01451658 UNKNOWN
Gastroesophageal Varices Hemorrhage; Hepatocellular Carcinoma
Taipei Veterans General Hospital, Taiwan
 2009-12 PHASE4
NCT04005365 UNKNOWN
Gastric Cancer
Yijing He
 2019-11-20 PHASE2
NCT04208594 UNKNOWN
Ivabradine; Propranolol; Hypotensive Anesthesia
Alexandria University
 2019-12-11
NCT02505971 COMPLETED
Infantile Hemangioma
The Hospital for Sick Children
 2015-09 PHASE3
NCT03379181 COMPLETED
Hyperthyroidism
University Hospital, Basel, Switzerland
 2017-07-18 PHASE4
NCT01007994 COMPLETED
Hypertension Secondary to Kidney Transplant
Northwell Health
 2009-11 PHASE2; PHASE3
NCT02484573 UNKNOWN
Liver Cirrhoses
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
 2015-05
NCT02897986 UNKNOWN
Pediatric Cancer
Assistance Publique Hopitaux De Marseille
 2017-01 PHASE1
NCT02789982 COMPLETED
Post-traumatic Stress Disorder
Assistance Publique - Hôpitaux de Paris
 2016-05-27 PHASE3
NCT03161964 TERMINATED
Type 1 Diabetes Mellitus
Anu Sharma
 2017-10-19 PHASE2
NCT01978457 TERMINATED
Cocaine Dependent Subjects
Yale University
 2012-10 PHASE1
NCT03323710 WITHDRAWN
Renal Cell Carcinoma
Military Institute od Medicine National Research Institute
 2018-09 PHASE2
NCT03652922 UNKNOWN
Stress Disorders, Post-Traumatic
Massachusetts General Hospital
 2018-09 PHASE4
NCT04140591 TERMINATED
Liver Cirrhosis; Peptic Ulcer
Taipei Veterans General Hospital, Taiwan
 2016-12-26 PHASE2; PHASE3
NCT03783065 UNKNOWN
Portal Hypertension; Variceal Rebleeding
Nanfang Hospital, Southern Medical University
 2019-01-02
NCT03388957 COMPLETED
Extrusion of Tooth
Damascus University
 2018-07-30
NCT03882255 COMPLETED
Healthy
Janssen Pharmaceutica N.V., Belgium
 2019-03-20 PHASE1
NCT01504126 COMPLETED
Fallopian Tube Clear Cell Adenocarcinoma; Fallopian Tube Endometrioid Adenocarcinoma; Fallopian Tube Mucinous Adenocarcinoma; Fallopian Tube Serous Adenocarcinoma; Fallopian Tube Undifferentiated Carcinoma; Ovarian Clear Cell Adenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Adenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Adenocarcinoma; Ovarian Undifferentiated Carcinoma; Primary Peritoneal Serous Adenocarcinoma; Stage II Fallopian Tube Cancer AJCC v6 and v7; Stage II Ovarian Cancer AJCC v6 and v7; Stage IIA Fallopian Tube Cancer AJCC v6 and v7; Stage IIA Ovarian Cancer AJCC V6 and v7; Stage IIB Fallopian Tube Cancer AJCC v6 and v7; Stage IIB Ovarian Cancer AJCC v6 and v7; Stage IIC Fallopian Tube Cancer AJCC v6 and v7; Stage IIC Ovarian Cancer AJCC v6 and v7; Stage III Fallopian Tube Cancer AJCC v7; Stage III Ovarian Cancer AJCC v6 and v7; Stage III Primary Peritoneal Cancer AJCC v7; Stage IIIA Fallopian Tube Cancer AJCC v7; Stage IIIA Ovarian Cancer AJCC v6 and v7; Stage IIIA Primary Peritoneal Cancer AJCC v7; Stage IIIB Fallopian Tube Cancer AJCC v7; Stage IIIB Ovarian Cancer AJCC v6 and v7; Stage IIIB Primary Peritoneal Cancer AJCC v7; Stage IIIC Fallopian Tube Cancer AJCC v7; Stage IIIC Ovarian Cancer AJCC v6 and v7; Stage IIIC Primary Peritoneal Cancer AJCC v7; Stage IV Fallopian Tube Cancer AJCC v6 and v7; Stage IV Ovarian Cancer AJCC v6 and v7; Stage IV Primary Peritoneal Cancer AJCC v7
M.D. Anderson Cancer Center
 2012-03-09 EARLY_PHASE1
NCT03309943 COMPLETED
Cigarette Smoking
Duke University
 2018-01-16 PHASE4
NCT00966082 UNKNOWN
Cirrhosis; Variceal Bleeding
Korea University
 2008-08 PHASE4
NCT00966121 UNKNOWN
Cirrhosis; Variceal Bleeding
Korea University
 2008-08 PHASE4
NCT02962947 UNKNOWN
Melanoma
Azienda Sanitaria di Firenze
 2017-06 PHASE2; PHASE3
NCT01902810 TERMINATED
Burn
The University of Texas Medical Branch, Galveston
 2013-07 PHASE2; PHASE3
NCT03251326 TERMINATED
Cannabis; Post Traumatic Stress Disorder
New York State Psychiatric Institute
 2015-10 PHASE1; PHASE2
NCT00965900 UNKNOWN
Variceal Bleeding; Cirrhosis
Korea University
 2006-09 PHASE4
NCT03079921 COMPLETED
Type1diabetes; Hypoglycemia; Hypoglycemia Unawareness; Islet Cell Transplantation
University of Pennsylvania
 2017-01-20 EARLY_PHASE1
NCT03254186 WITHDRAWN
Tardive Dyskinesia
Emory University
 2017-09-18 PHASE2; PHASE3
NCT03533699 UNKNOWN
Induction of Labor Affected Fetus / Newborn
Ain Shams Maternity Hospital
 2016-10-01
NCT03523650 UNKNOWN
Cavernous Malformations,Cerebral and/or Spinal
University of Virginia
 2018-02-07 PHASE1
NCT01847001 COMPLETED
Locally Advanced Malignant Neoplasm; Breast Cancer
Columbia University
 2012-10 PHASE2
NCT01791114 COMPLETED
Insulin Sensitivity; Obesity
Rutgers University
 2012-01
NCT03348683 COMPLETED
Induction of Labor Affected Fetus / Newborn
Icahn School of Medicine at Mount Sinai
 2017-12-11 PHASE2
NCT02452255 TERMINATED
Burn
The University of Texas Medical Branch, Galveston
 2015-11 PHASE2; PHASE3
NCT03038295 UNKNOWN
Retinopathy of Prematurity
Guangdong Women and Children Hospital
 2017-03 PHASE2
NCT03237637 UNKNOWN
Infantile Hemangioma
Post Graduate Institute of Medical Education and Research, Chandigarh
 2017-03-24 PHASE3
NCT02268357 COMPLETED
Dental Anxiety
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2014-11 PHASE2; PHASE3
NCT01957449 TERMINATED
Burn
The University of Texas Medical Branch, Galveston
 2013-12 PHASE2; PHASE3
NCT01822587 COMPLETED
Cocaine Addiction
Medical University of South Carolina
 2013-09 PHASE2
NCT02477384 COMPLETED
Portal Hypertension
West China Hospital
 2015-06
NCT03609307 UNKNOWN
Age Related Macular Degeneration
Shahid Beheshti University of Medical Sciences
 2018-09 PHASE2; PHASE3
NCT00675714 TERMINATED
Burns
The University of Texas Medical Branch, Galveston
 2004-01 PHASE2; PHASE3
NCT02342275 COMPLETED
Hemangioma
West China Hospital
 2013-10 PHASE3
NCT02631694 UNKNOWN
Panic Disorder
VU University of Amsterdam
 2016-04 PHASE2
NCT02596776 COMPLETED
Obese; Normal Body Weight; Prediabetes; Metabolic Syndrome
Philip Kern
 2016-03 EARLY_PHASE1
NCT02504944 COMPLETED
Retinopathy of Prematurity
Meyer Children's Hospital IRCCS
 2015-07 PHASE2
NCT02420223 COMPLETED
Multiple Myeloma
Medical College of Wisconsin
 2015-07-17 PHASE2
NCT01555554 TERMINATED
Post-traumatic Stress Disorder
University of California, San Francisco
 2012-05 PHASE4
NCT03364075 TERMINATED
Low Back Pain
Mark Ware
 2017-09-01 PHASE2
NCT02957331 COMPLETED
Brain Injuries, Traumatic
University of Tennessee
 2016-01 PHASE4
NCT02732678 UNKNOWN
Angiosarcoma
Assistance Publique Hopitaux De Marseille
 2016-05 PHASE1; PHASE2
NCT02437383 COMPLETED
Temporomandibular Disorders
University of North Carolina, Chapel Hill
 2015-08-20 PHASE2
NCT03029845 TERMINATED
Fibromyalgia Pain
University of Utah
 2017-01 PHASE1
NCT02977000 UNKNOWN
Retinopathy of Prematurity
Huiqing Sun
 2016-05
NCT02740166 UNKNOWN
Esophageal Varices
Kaohsiung Veterans General Hospital.
 2013-06 PHASE4
NCT02853526 UNKNOWN
Portal Vein, Cavernous Transformation of; Portal Vein Thrombosis; Liver Cirrhosis; Bleeding Esophageal Varices
Zaibo Jiang
 2015-07 PHASE3
NCT02104011 TERMINATED
Renal Angiomyolipomas; Tuberous Sclerosis
University Hospital, Bordeaux
 2015-05-22 PHASE2
NCT03270644 COMPLETED
Healthy
Eli Lilly and Company
 2017-08-31 PHASE1
NCT02467400 COMPLETED
Osteoporosis, Age-Related
Mayo Clinic
 2015-07-01 EARLY_PHASE1
NCT03401515 COMPLETED
Traumatic Brain Injury
Ain Shams University
 2016-10-01 PHASE4
NCT02385422 UNKNOWN
Liver Cirrhosis; Esophageal and Gastric Varices; Hemorrhage
Shanghai Zhongshan Hospital
 2015-03 PHASE4
NCT05327309 COMPLETED
Hemangioma; Propranolol
Shaheed Zulfiqar Ali Bhutto Medical University
 2015-05-08
NCT02596867 TERMINATED
Breast Cancer
Texas Tech University Health Sciences Center, El Paso
 2015-09-01 PHASE2
NCT01713556 COMPLETED
Post-traumatic Stress Disorder
University Hospital, Toulouse
 2012-11 PHASE2
NCT02495883 COMPLETED
Essential Tremor; Tremor
University of California, San Diego
 2013-12 PHASE4
NCT02934763 UNKNOWN
Hyperalgesia
Pontificia Universidad Catolica de Chile
 2016-10 PHASE4
NCT01705392 TERMINATED
Metastatic Malignant Melanoma; Unresectable Malignant Melanoma
Haukeland University Hospital
 2013-01 PHASE2
NCT01897051 UNKNOWN
Liver Cirrhosis; Portal Hypertension
Yonsei University
 2013-07 PHASE2; PHASE3
NCT00888797 UNKNOWN
Colorectal Neoplasms
Sheba Medical Center
 2010-01 PHASE3
NCT02508623 UNKNOWN
Liver Cirrhosis; Portal Hypertension
University of Padova
 2015-07 PHASE3
NCT02808611 COMPLETED
Healthy Subjects
Kristian Kjær Petersen
 2016-07
NCT02649335 COMPLETED
Ascites
Post Graduate Institute of Medical Education and Research, Chandigarh
 2015-07-01 PHASE3
NCT02702674 UNKNOWN
Poor; Labor
Ain Shams Maternity Hospital
 2015-12 PHASE3
NCT02511483 TERMINATED
Postoperative Pain
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2015-05-18 PHASE2
NCT02414451 WITHDRAWN
Autism
University of Missouri-Columbia
 2016-09
NCT01857817 TERMINATED
Prostatic Neoplasms
Vicus Therapeutics
 2013-06 PHASE2
NCT02171988 COMPLETED
Postural Orthostatic Tachycardia Syndrome
Seoul National University Hospital
 2014-03 PHASE4
NCT01458600 COMPLETED
Graves´ Disease
Mikael Lantz
 2006-09 PHASE4
NCT01326949 COMPLETED
Decompensated Cirrhosis; Portal Vein Thrombosis; Bleeding Varices
Air Force Military Medical University, China
 2011-05
NCT00502684 UNKNOWN
Primary Operable Breast Cancer
Kaplan Medical Center
 2014-06
NCT01535495 COMPLETED
Proliferative Diabetic Retinopathy
University of Wisconsin, Madison
 2012-02 PHASE1
NCT04074473 UNKNOWN
Acute Kidney Injury; Cirrhosis; Esophageal Varices
Taipei Veterans General Hospital, Taiwan
 2015-04-13 PHASE4
NCT00611871 TERMINATED
Posttraumatic Stress Disorders
Wayne State University
 2007-09 PHASE2
NCT01059396 COMPLETED
Portal Hypertension Gastropathy; Esophageal Varices; Spontaneous Bacterial Peritonitis; Hepatic Encephalopathy; Ascites
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
 2010-01-28 PHASE4
NCT02013492 COMPLETED
Male Breast Cancer; Recurrent Melanoma; Stage IV Breast Cancer; Stage IV Melanoma; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Unspecified Adult Solid Tumor, Protocol Specific; Hepatocellular Carcinoma
William Carson
 2014-01-21 EARLY_PHASE1
NCT01743885 TERMINATED
Hemangioma
University Hospital, Montpellier
 2012-11 PHASE3
NCT01908972 COMPLETED
Hemangioma
Seoul National University Hospital
 2013-06 PHASE4
NCT00770484 COMPLETED
Orthostatic Intolerance; Postural Tachycardia Syndrome
Vanderbilt University
 2008-11
NCT01202110 TERMINATED
Traumatic Brain Injury
Cedars-Sinai Medical Center
 2010-06 PHASE2
NCT02032758 COMPLETED
Occupational; Cramp(s)
Mayo Clinic
 2014-01 PHASE4
NCT01349439 UNKNOWN
Posttraumatic Stress Disorder
Douglas Mental Health University Institute
 2011-03 PHASE2
NCT01322048 COMPLETED
Brain Injuries; Craniocerebral Trauma; Trauma, Nervous System; Traumatic Brain Injury
Vanderbilt University
 2011-08 PHASE2
NCT01631682 COMPLETED
Posttraumatic Stress Disorder; Anxiety Disorder
Massachusetts General Hospital
 2010-11 PHASE4
NCT01072045 COMPLETED
Hemangioma
University of Sao Paulo
 2010-01 PHASE2
NCT02111369 COMPLETED
Essential Vocal Tremor; Essential Voice Tremor; Essential Tremor; Voice Tremor; Vocal Tremor
Emory University
 2014-05 PHASE4
NCT02350985 COMPLETED
Vestibular Migraine
Haseki Training and Research Hospital
 2014-01 PHASE4
NCT02179775 UNKNOWN
Migraine Headache; Gastric Diseases
Shiraz University of Medical Sciences
 2014-07
NCT01308944 COMPLETED
Invasive Epithelial Ovarian Cancer; Primary Peritoneal Carcinoma; Fallopian Tube Cancer
Washington University School of Medicine
 2010-08 PHASE1
NCT02014454 COMPLETED
Retinopathy of Prematurity
Meyer Children's Hospital IRCCS
 2013-11 PHASE2
NCT01634347 COMPLETED
Substance Dependence
Douglas Mental Health University Institute
 2012-01 PHASE2
NCT01343329 WITHDRAWN
Traumatic Brain Injury; Dysautonomia
Johns Hopkins University
 2011-07 PHASE1; PHASE2
NCT01265576 UNKNOWN
HCC
Vicus Therapeutics
 2010-12 PHASE2
NCT02509559 COMPLETED
Emotions
University Medicine Greifswald
 2013-10 PHASE1
NCT00688805 TERMINATED
Cocaine Dependence
National Institute on Drug Abuse (NIDA)
 2007-12-12 PHASE1
NCT01077921 COMPLETED
Sickle Cell Disease
Laura M. De Castro, MD
 2010-06 PHASE2
NCT01544634 COMPLETED
Asthma
University of Dundee
 2012-04-04 PHASE2
NCT01512173 COMPLETED
Infantile Hemangioma
Pierre Fabre Dermatology
 2012-01 PHASE2
NCT00862095 TERMINATED
Headache
Madigan Army Medical Center
 2008-06 PHASE4
NCT01784250 UNKNOWN
Anxiety
CES University
 2012-08 PHASE2
NCT00967226 TERMINATED
Hemangioma of Infancy
Nancy Bauman
 2009-07 PHASE2
NCT01087749 COMPLETED
Kidney Disease
University of California, San Francisco
 2010-03 PHASE1
NCT02012777 TERMINATED
Sickle Cell Disease
University of Miami
 2010-06 PHASE1
NCT01079715 COMPLETED
Retinopathy of Prematurity
Meyer Children's Hospital IRCCS
 2010-01 PHASE2; PHASE3
NCT01333150 UNKNOWN
Temporomandibular Joint Disorders; Myofascial Temporomandibular Disorders
University of Aarhus
 2011-08
NCT01055171 COMPLETED
Alcohol Dependence; PTSD
Medical University of South Carolina
 2010-01 PHASE2
NCT00251602 COMPLETED
Healthy
National Institute on Aging (NIA)
 2003-03 PHASE1
NCT01056341 COMPLETED
Infantile Hemangioma
Pierre Fabre Dermatology
 2010-01 PHASE2; PHASE3
NCT01238471 COMPLETED
Retinopathy of Prematurity
Rambam Health Care Campus
 2010-05 PHASE1; PHASE2
NCT00884663 COMPLETED
Migraine Without Aura; Migraine With Aura; Chronic Migraine
Norwegian University of Science and Technology
 2009-04 PHASE2; PHASE3
NCT01074853 COMPLETED
Asthma
University of Dundee
 2010-05 PHASE2
NCT01074437 TERMINATED
Hemangioma
Seattle Children's Hospital
 2010-02 PHASE2
NCT01655303 COMPLETED
Rapid Ventricular Response Atrial Fibrillation
Tehran University of Medical Sciences
 2011-02 PHASE4
NCT01061190 COMPLETED
Stroke
Wilhelm Haverkamp
 2010-01 PHASE2; PHASE3
NCT01069159 UNKNOWN
Traumatic Memory; Posttraumatic Stress Disorder
Mela, Mansfield, M.D.
 2010-02
NCT00830362 COMPLETED
Cocaine Dependence
Medical University of South Carolina
 2009-02 PHASE2
NCT01893541 COMPLETED
CIRRHOSIS; ESOPHAGEAL VARICES
Federal University of São Paulo
 2008-06 PHASE4
NCT01222091 COMPLETED
Hyperalgesia
Stanford University
 2009-02 PHASE2
NCT00673309 COMPLETED
Burns
The University of Texas Medical Branch, Galveston
 2000-07 PHASE2; PHASE3
NCT01263197 COMPLETED
Major Depressive Disorder
Eli Lilly and Company
 2010-12 PHASE1
NCT00934947 COMPLETED
Burns; Pain
University of North Carolina, Chapel Hill
 2009-07 PHASE2
NCT00651235 UNKNOWN
Marfan Syndrome
National Taiwan University Hospital
 2007-02 PHASE2
NCT00777218 WITHDRAWN
Migraine
University of South Alabama
 2007-08
NCT01058317 WITHDRAWN
Recurrent Respiratory Papillomatosis
Massachusetts Eye and Ear Infirmary
 2010-01 PHASE2; PHASE3
NCT01127568 UNKNOWN
Stress Disorders, Post-Traumatic
Douglas Mental Health University Institute
 2010-02 PHASE2; PHASE3
NCT00772031 COMPLETED
Chronic Migraine
Anne Lindblad
 2008-10 PHASE3
NCT01070225 COMPLETED
Asthma
University of Dundee
 2010-03 PHASE4
NCT00390546 COMPLETED
Supraventricular Tachycardia
University of British Columbia
 2006-10 PHASE3
NCT00916721 COMPLETED
Smoking Cessation
Massachusetts General Hospital
 2008-04 PHASE3
NCT01007084 WITHDRAWN
Trauma
University of North Carolina, Chapel Hill
 2009-10 PHASE2
NCT00645450 TERMINATED
Posttraumatic Stress Disorders
VA Office of Research and Development
 2008-04 PHASE4
NCT01094574 COMPLETED
Pain Measurement
Martin Angst
 2010-01
NCT01298284 UNKNOWN
Liver Cirrhosis; Hepatoma
Taipei Veterans General Hospital, Taiwan
 2009-10 PHASE4
NCT00744185 TERMINATED
Hemangioma, Capillary
University Hospital, Bordeaux
 2008-10 PHASE2; PHASE3
NCT00709735 COMPLETED
Posttraumatic Stress Disorder
Massachusetts General Hospital
 2007-05 PHASE4
NCT01284868 COMPLETED
Healthy Volunteers; Pharmacodynamics of Mirabegron
Astellas Pharma Inc
 2009-07 PHASE1
NCT01000779 COMPLETED
Non Cirrhotic Portal Hypertension
Govind Ballabh Pant Hospital
 2005-01 PHASE3
NCT00902161 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
 2009-05 PHASE1
NCT01080677 COMPLETED
Migraine Disorders
Stanford University
 2007-01 PHASE2
NCT00493480 COMPLETED
Cirrhosis; Portal Hypertension
Hvidovre University Hospital
 2003-09 PHASE3
NCT00356187 TERMINATED
Trauma
Denver Health and Hospital Authority
 2006-02-15 PHASE2
NCT00888784 COMPLETED
Cirrhosis
Govind Ballabh Pant Hospital
 2006-08
NCT00905996 COMPLETED
Cirrhosis
Govind Ballabh Pant Hospital
 2006-08
NCT00588965 COMPLETED
Long QT Syndrome; Cardiac Repolarization
MetroHealth Medical Center
 2007-08
NCT00465608 COMPLETED
Post-Traumatic Stress Disorder
University Hospital, Toulouse
 2007-04 PHASE2
NCT00772057 COMPLETED
Cirrhosis
Govind Ballabh Pant Hospital
 2004-10
NCT00332904 UNKNOWN
Liver Cirrhosis; Portal Hypertension
Hvidovre University Hospital
 2006-08 PHASE4
NCT01060111 COMPLETED
Migraine
Janssen Korea, Ltd., Korea
 2006-07 PHASE4
NCT00759005 COMPLETED
Heroin Dependence; Learning and Memory
National Institute on Drug Dependence, China
 2007-03
NCT00687700 COMPLETED
Pulmonary Disease, Chronic Obstructive
Theravance Biopharma
 2008-03-10 PHASE1
NCT00158262 COMPLETED
Post-Traumatic Stress Disorder
Massachusetts General Hospital
 2004-09 PHASE4
NCT00315913 WITHDRAWN
Dysfunctional Labor
University of California, Irvine
 2004-01 PHASE2
NCT00654290 COMPLETED
Atrial Fibrillation
Shiraz University of Medical Sciences
 2007-03
NCT00549120 COMPLETED
Pulmonary Disease, Chronic Obstructive
GlaxoSmithKline
 2007-08-15 PHASE1
NCT00766805 COMPLETED
Portal Hypertension
Govind Ballabh Pant Hospital
 2002-10
NCT00652600 COMPLETED
To Determine Bioequivalence Under Fed Conditions
Par Pharmaceutical, Inc.
 2005-09 PHASE1
NCT00653120 COMPLETED
To Determine Bioequivalence Under Fasting Conditions
Par Pharmaceutical, Inc.
 2005-05 PHASE2
NCT00597389 COMPLETED
Posttraumatic Stress Disorders
Kent State University
 2004-02
NCT02256722 COMPLETED
Healthy
Boehringer Ingelheim
 2005-10 PHASE1
NCT00910689 COMPLETED
Migraine Headache
Ohio University
 2001-07 PHASE4
NCT00647608 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2005-09 PHASE1
NCT00647816 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2005-09 PHASE1
NCT00864747 COMPLETED
Healthy
Actavis Inc.
 2005-05 PHASE1
NCT00865215 COMPLETED
Healthy
Actavis Inc.
 2005-04 PHASE1
NCT00158132 COMPLETED
Cocaine-Related Disorders
University of Pennsylvania
 1999-09 PHASE2
NCT00000197 COMPLETED
Cocaine-Related Disorders
National Institute on Drug Abuse (NIDA)
 1987-01 PHASE2
NCT02264093 COMPLETED
Healthy
Boehringer Ingelheim
 1999-11 PHASE1
NCT00093860 COMPLETED
Syncope
National Institute of Neurological Disorders and Stroke (NINDS)
 2004-10 PHASE2
NCT00000492 COMPLETED
Arrhythmia; Cardiovascular Diseases; Coronary Disease; Death, Sudden, Cardiac; Heart Diseases; Myocardial Infarction; Myocardial Ischemia; Ventricular Fibrillation
National Heart, Lung, and Blood Institute (NHLBI)
 1977-09 PHASE3
NCT00060866 COMPLETED
Neurocardiogenic Syncope
National Institute of Neurological Disorders and Stroke (NINDS)
 2003-05 PHASE4
NCT00889096 COMPLETED
Memory; Heart Rate; Skin Electric Conductance; Amylase; Propanolol
University Medicine Greifswald
 PHASE1
NCT00069355 COMPLETED
Stress Disorders, Traumatic, Acute
National Institute of Mental Health (NIMH)
 2003-09 PHASE2
NCT00016666 COMPLETED
Seasonal Affective Disorder; Healthy
National Institute of Mental Health (NIMH)
 2001-05-21 PHASE2
NCT00337740 TERMINATED
Liver Cirrhosis; Esophageal Varices
University of Padova
 PHASE3
NCT01205074 UNKNOWN
Healthy Subjects; Chronic Liver Disease; Cirrhosis
Hadassah Medical Organization
 2010-09 PHASE2; PHASE3
NCT00236561 COMPLETED
Migraine; Common Migraine; Classic Migraine; Headache
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2001-04 PHASE3
NCT00188045 TERMINATED
Alcoholic Cirrhosis
University Hospital, Angers
 1995-04 PHASE4
NCT00000493 COMPLETED
Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Infarction; Myocardial Ischemia
National Heart, Lung, and Blood Institute (NHLBI)
 1977-09 PHASE3
NCT01134692 UNKNOWN
Cirrhosis; Varices, Esophageal
Govind Ballabh Pant Hospital
 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-06-17)

Check the Propranolol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Propranolol functions as a non-selective antagonist of β1- and β2-adrenergic receptors with nanomolar affinity, inhibiting intracellular cAMP accumulation and modulating downstream MAPK signaling pathways to exert antiproliferative and antisurvival effects on target cells. This targeted inhibition of adrenergic signaling underlies its efficacy in suppressing tumor growth and aberrant vascular proliferation in conditions such as hemangiomas and ovarian carcinomas evaluated across clinical trials.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.