CAS No. 318-98-9
| CAS Number | 318-98-9 | |
|---|---|---|
| Molecular Formula |
C16H21NO2.HCl |
|
| Molecular Weight (MW) | 295.8 | |
| SMILES | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl |
Propranolol HCl is a competitive, non-selective antagonist of beta-1 and beta-2 adrenergic receptors. By blocking beta-adrenergic receptor signaling, it suppresses intracellular cAMP accumulation and inhibits downstream protein kinase A (PKA) pathway activity. Consequently, this inhibition reduces vascular endothelial growth factor (VEGF) expression, leading to impaired cell proliferation, decreased migration, and attenuated angiogenesis in preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(199.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 6 mg/mL |
| Ethanol | Insoluble |
| DMSO |
59 mg/mL
(199.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 59 mg/mL |
| Ethanol | Insoluble |
| DMSO |
59 mg/mL
(199.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 59 mg/mL |
| Ethanol | Insoluble |
| Water | 100 mg/mL |
| DMSO |
59 mg/mL
(199.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.