1,2-Propanediol SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: 1,2-Propanediol
CAS Number: 57-55-6
PubChem CID: 1030
Molecular formula: C3H8O2
Molecular weight: 76.09 g/mol
IUPAC name: propane-1,2-diol

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Fresh air, rest.
Skin contact: Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eye contact: Rinse with plenty of water (remove contact lenses if easily possible).
Ingestion: Rinse mouth. Seek medical attention if you feel unwell.

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
Fire Extinguishing Agents: Water fog, alcohol foam, carbon dioxide, dry chemical. (USCG, 1999)
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
Water fog, alcohol foam, carbon dioxide, dry chemical.
In case of fire, keep drums, etc, cool by spraying water.
Vapor is heavier than air.

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.
Flash point: 210 °F (NTP, 1992)

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
Collect leaking and spilled liquid in sealable containers as far as possible. Wash away spilled liquid with plenty of water.
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.
SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.
Above 99 °C use a closed system, ventilation.
Propylene glycol should be handled in a well-ventilated environment; eye protection is recommended.

7.1 Precautions for safe handling
SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should protect this material from exposure to light and moisture. Keep it away from oxidizing materials and store it under refrigerated temperatures. (NTP, 1992)
Separated from strong oxidants and alkalis. Dry. Well closed. Ventilation along the floor.
Propylene glycol is hygroscopic and should be stored in a well-closed container, protected from light, in a cool, dry place.
Propylene glycol, dipropylene glycol, and tripropylene glycol are stable materials that require no special handling procedures. They are noncorrosive and can be transported or stored in stainless steel, aluminum, and lined steel containers. Carbon steel is also acceptable, although slight iron contamination may occur upon extended periods of storage. U.S.P.-grade propylene glycol is typically stored in stainless steel.

7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and alkalis. Dry. Well closed. Ventilation along the floor.
Propylene glycol is hygroscopic and should be stored in a well-closed container, protected from light, in a cool, dry place.
Propylene glycol, dipropylene glycol, and tripropylene glycol are stable materials that require no special handling procedures. They are noncorrosive and can be transported or stored in stainless steel, aluminum, and lined steel containers. Carbon steel is also acceptable, although slight iron contamination may occur upon extended periods of storage. U.S.P.-grade propylene glycol is typically stored in stainless steel.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]
Store in original container. Keep upright to prevent leakage.

9.1 Information on basic physical and chemical properties
a) Appearance: Thick odorless colorless liquid. Mixes with water. (USCG, 1999)
b) Odor: Practically odorless
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: -76 °F (NTP, 1992)
f) Initial boiling point and boiling range: 370.8 °F at 760 mmHg (NTP, 1992)
g) Flash point: 210 °F (NTP, 1992)
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 0.08 mmHg at 68 °F ; 0.13 mmHg at 77 °F (NTP, 1992)
l) Vapor density: No data available
m) Relative density: 1.04 at 68 °F (USCG, 1999) - Denser than water; will sink
n) Water solubility: greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): -0.9
p) Auto-ignition temperature: 700 °F (USCG, 1999)
q) Decomposition temperature: No data available
r) Viscosity: 0.581 cP at 20 °C
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 40.5 Ų
Complexity: 20

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
No data available.
Respiratory or skin sensitization:
No data available.
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
H370, H372
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Carcinogen classification:
No indication of carcinogenicity to humans (not listed by IARC).
Signs and symptoms of exposure:
Dry throat. Cough.
Dryness of eyes. Pain. Itching.
See Effects of short-term exposure
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
EC50; Species: Selenastrum capricornutum (green algae); Concentration: 19,000 mg/L for 96 hr; Effect: 14-day growth rate /Conditions of bioassay not specified/
EC50; Species: Selenastrum capricornutum (green algae); Concentration: 18,100 mg/L for 14 days; Effect: 14-day growth rate /Conditions of bioassay not specified/
EC50; Species: Daphnia magna (Water flea, age 6-24 hr); Conditions: freshwater, static, 20 °C, pH > or =7.0; Concentration: >10000000 ug/L for 24, 48 hr; Effect: intoxication, immobilization /formulation/
LC50; Species: Daphnia magna (water flea); Conditions: static; Concentration: 43,500 mg/L for 48 hr
For more Ecotoxicity Values (Complete) data for Propylene glycol (23 total), please visit the HSDB record page.
/BIRDS and MAMMALS/ Due to the low likelihood of exposure and low toxicity of propylene glycol ..., the /Environmental Protection/ Agency expects no effects to listed species or critical habitats and therefore makes a "No Effect" determination for this chemical.
/AQUATIC SPECIES/ The very low toxicity of propylene glycol to aquatic organisms, as indicated by the high LC50 values ..., further supports the unlikelihood of adverse effects to fish and aquatic invertebrates.
/AQUATIC SPECIES/ ...This research investigated the contributions of environmentally significant concentrations of selected /aircraft deicing fluid/ (ADF) components to the toxicity of ADF-containing waste streams, and to the inhibition of biodegradation of propylene glycol (PG), the m

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
Log P (n-octanol/water): -0.9
Low potential for bioaccumulation (Log P < 3).

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
No other adverse ecological effects identified.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).

14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).

14.5 Environmental hazards
Marine pollutant: No (not classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered (REACH Active)

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Chronic (long-term) health hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: 1,2-Propanediol
- EFSA Legal Basis: Regulation (EC) No 1333/2008 (amended)
- Atmospheric Standards: This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to us
- State Drinking Water Standards: (NY) NEW YORK 1,000 ug/L
- State Drinking Water Guidelines: (NH) NEW HAMPSHIRE 140,000 ug/ L

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.