CAS No. 366-70-1

Batch: Purity:99.45
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Procarbazine HCl Chemical Structure
Chemical Structure
Check the Procarbazine HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide;hydrochloride
CAS Number 366-70-1
Molecular Formula

C12H19N3O.HCl
Molecular Weight (MW) 257.76
SMILES CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl
InChIKey DERJYEZSLHIUKF-UHFFFAOYSA-N

Ordering Information

Biological Activity

Procarbazine hydrochloride is an orally active polyfunctional alkylating agent and DNA synthesis inhibitor. Metabolic activation of procarbazine generates reactive methylating intermediates that disrupt DNA, RNA, and protein synthesis. This inhibition impairs cellular mitosis and arrests cell division midway through the cell cycle, ultimately resulting in the cytostatic suppression of neoplastic cell proliferation.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 52 mg/mL
Ethanol 52 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.