SMILES:

C1CN2CCC1C(=O)C2(CO)CO
PRIMA-1 Chemical Structure
Chemical Structure
Check the PRIMA-1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
CAS Number 5608-24-2
Molecular Formula

C9H15NO3
Molecular Weight (MW) 185.22
SMILES C1CN2CCC1C(=O)C2(CO)CO
InChIKey RFBVBRVVOPAAFS-UHFFFAOYSA-N

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 37 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 37 mg/mL
Ethanol 37 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.