CAS No. 637-58-1
Batch:
Purity:99.89
Chemical Structure
Check the
Pramoxine HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 637-58-1 | |
|---|---|---|
| Molecular Formula |
C17H27NO3.HCl |
|
| Molecular Weight (MW) | 329.86 | |
| SMILES | CCCCOC1=CC=C(C=C1)OCCCN2CCOCC2.Cl |
Biological Activity
Pramoxine HCl (Pramocaine hydrochloride) is a topical local anesthetic that acts as a neuronal membrane stabilizer by blocking voltage-gated sodium channels. By inhibiting sodium ion influx across nerve cell membranes, it prevents the initiation and conduction of sensory nerve impulses. This interruption of neural signaling attenuates itch and pain transmission in cutaneous nerves, leading to significant antipruritic and local anesthetic effects.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(200.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 66 mg/mL |
| Ethanol | 66 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.