CAS No. 1225037-39-7

Batch: Purity:99.02
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Bimiralisib (PQR309) Chemical Structure
Chemical Structure
Check the Bimiralisib (PQR309) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
CAS Number 1225037-39-7
Molecular Formula

C17H20F3N7O2
Molecular Weight (MW) 411.38
SMILES C1COCCN1C2=NC(=NC(=N2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
InChIKey ADGGYDAFIHSYFI-UHFFFAOYSA-N

Ordering Information

Biological Activity

Bimiralisib (PQR309) is a potent, brain-penetrant dual class I PI3K and mTOR inhibitor. It selectively targets PI3K isoforms and mTOR kinase, suppressing the downstream PI3K/AKT/mTOR signaling cascade. Inhibition of this pathway leads to reduced cellular proliferation, diminished survival signaling, and the induction of apoptosis in lymphoma models both in vitro and in vivo.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 6 mg/mL (14.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.