Synonyms: C5
Pozelimab (Anti-Complement C5) is a fully human IgG4 monoclonal antibody targeting C5. It can be used for the research of complement-mediated diseases. MW :144.78 KD.
| Featured Inhibitors | Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933 |
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| Description |
Pozelimab (Anti-Complement C5) is a fully human IgG4 monoclonal antibody targeting C5. It can be used for the research of complement-mediated diseases. MW :144.78 KD.
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References |
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| CAS No. | 2096328-94-6 |
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| Isotype | Human IgG4SP |
| Source | CHO |
| Formulation | 100 mM Pro-Ac, 20mM Arg, pH5.0 |
| Storage (From the date of receipt) |
Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. |
*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT07142343 | RECRUITING | Drug: Pozelimab | CHAPLE Disease | Regeneron Pharmaceuticals | 2026-03-19 | PHASE4 |
| NCT07154745 | RECRUITING | Drug: Pozelimab|Drug: Cemdisiran | Paroxysmal Nocturnal Hemoglobinuria | Regeneron Pharmaceuticals | 2026-06-11 | PHASE3 |
| NCT07520318 | NOT_YET_RECRUITING | Drug: bispecific anti-VEGF and anti-complement | Adults With Neovascular Age-related Macular Degeneration | Shenzhen Oculgen Biomedical Technology Co., Ltd. | 2026-04-17 | PHASE2; PHASE3 |
| NCT05744921 | RECRUITING | Drug: Pozelimab|Drug: Cemdisiran | Paroxysmal Nocturnal Hemoglobinuria | Regeneron Pharmaceuticals | 2023-03-07 | PHASE3 |
| NCT06541704 | RECRUITING | Drug: Pozelimab|Drug: Cemdisiran|Drug: Placebo | Age-related Macular Degeneration (AMD); Geographic Atrophy (GA) | Regeneron Pharmaceuticals | 2024-10-30 | PHASE3 |
| NCT07230834 | RECRUITING | Drug: Pozelimab | Geographic Atrophy (GA) | Regeneron Pharmaceuticals | 2026-01-19 | PHASE1 |
(data from https://clinicaltrials.gov, updated on 2026-04-13)
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