Pomalidomide is a potent CRBN molecular glue. It affects NF-kB signaling by binding CRBN to degrade IKZF1/3, halting myeloma.
Comprehensive IC50 Values for Pomalidomide (CC-4047) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.
Pomalidomide is a potent CRBN molecular glue. It affects NF-kB signaling by binding CRBN to degrade IKZF1/3, halting myeloma.