Clinical Trials

Numerous clinical trials spanning Early Phase 1 through Phase 4 evaluate pomalidomide across diverse oncological and hematological indications, focusing heavily on relapsed and refractory multiple myeloma, diffuse large B-cell lymphoma, and virus-associated malignancies such as Kaposi sarcoma. Sponsored by government organizations like the National Cancer Institute, academic centers, and pharmaceutical companies including Janssen and AbbVie, these studies exhibit a range of statuses, including recruiting, active non-recruiting, completed, and terminated.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05259839 ACTIVE_NOT_RECRUITING
Relapsed/Refractory Multiple Myeloma
AbbVie
2022-10-20 PHASE1
NCT05730036 RECRUITING
Relapsed Refractory Multiple Myeloma (RRMM)
Regeneron Pharmaceuticals
2023-09-18 PHASE3
NCT07748689 NOT_YET_RECRUITING
Relapsed / Refractory Multiple Myeloma
Polish Myeloma Consortium
2026-10 PHASE2
NCT07728188 NOT_YET_RECRUITING
Relapsed or Refractory Multiple Myeloma
AbbVie
2026-11-30 PHASE3
NCT06953960 RECRUITING
Multiple Myeloma
AbbVie
2025-07-23 PHASE1; PHASE2
NCT07227311 RECRUITING
Multiple Myeloma
GlaxoSmithKline
2026-04-15 PHASE2
NCT07720843 NOT_YET_RECRUITING
Relapse Multiple Myeloma; Refractory Multiple Myeloma
Montefiore Medical Center
2026-09-01 PHASE1
NCT07749365 RECRUITING
DLBCL - Diffuse Large B Cell Lymphoma; PCNSL (Primary CNS Lymphoma)
The First Affiliated Hospital of Xiamen University
2026-07-25 PHASE2
NCT07096778 RECRUITING
Multiple Myeloma Refractory; Multiple Myeloma in Relapse
CellCentric Ltd.
2026-01-22 PHASE2
NCT07772024 RECRUITING
Multiple Myeloma Refractory; Multiple Myeloma in Relapse
CellCentric Ltd.
2026-08 PHASE3
NCT07623798 NOT_YET_RECRUITING
Relapsed or Refractory Multiple Myeloma
Innovent Biologics (Suzhou) Co. Ltd.
2026-06-05 PHASE3
NCT07222761 RECRUITING
Relapsed and/or Refractory Multiple Myeloma (RRMM)
Regeneron Pharmaceuticals
2026-01-02 PHASE3
NCT07463807 RECRUITING
Recurrent Multiple Myeloma; Refractory Multiple Myeloma
National Cancer Institute (NCI)
2027-04-12 PHASE1; PHASE2
NCT07452198 RECRUITING
Multiple Myeloma
Genrix (Shanghai) Biopharmaceutical Co., Ltd.
2026-03-09 PHASE3
NCT05438043 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2022-12-15 PHASE3
NCT07579234 RECRUITING
Relapsed or Refractory Multiple Myeloma (RRMM)
Shandong New Time Pharmaceutical Co., LTD
2026-01-25 PHASE3
NCT06768489 RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2024-12-04 PHASE1
NCT07757412 NOT_YET_RECRUITING
Multiple Myeloma Progression
Odense University Hospital
2026-09-01 PHASE2
NCT05922501 RECRUITING
Relapsed Cancer; Refractory Multiple Myeloma; Multiple Myeloma
Massachusetts General Hospital
2024-05-31 PHASE2
NCT04910568 RECRUITING
Multiple Myeloma
Genentech, Inc.
2021-07-26 PHASE1
NCT07569757 NOT_YET_RECRUITING
Multiple Myeloma
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
2026-06 PHASE3
NCT05669989 ENROLLING_BY_INVITATION
Plasma Cell Myeloma
Sanofi
2023-04-05 PHASE2
NCT07555938 RECRUITING
Multiple Myeloma
Hoffmann-La Roche
2026-06-23 PHASE3
NCT05714839 RECRUITING
Multiple Myeloma
GlaxoSmithKline
2023-06-14 PHASE1; PHASE2
NCT07257510 RECRUITING
Mantle Cell Lymphoma (MCL); POZ
Peking University Third Hospital
2025-08-01
NCT05789303 RECRUITING
Multiple Myeloma; Relapse Multiple Myeloma
University of Chicago
2023-05-30 PHASE2
NCT07742215 RECRUITING
Myeloma Multiple
Biocad
2026-06-15 PHASE3
NCT07760610 NOT_YET_RECRUITING
Diffuse Large B-Cell Lymphoma (DLBCL)
The First Hospital of Jilin University
2026-09 PHASE4
NCT06413498 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Kite, A Gilead Company
2024-08-23 PHASE3
NCT07391657 RECRUITING
Relapsed Refractory Multiple Myeloma
AstraZeneca
2026-02-23 PHASE3
NCT05389423 RECRUITING
Diffuse Large Cell Lymphoma; Non-Hodgkin Lymphoma; Burkitt Lymphoma; Plasmablastic Lymphoma; B-Cell Neoplasm
National Cancer Institute (NCI)
2023-06-27 PHASE1
NCT07560449 NOT_YET_RECRUITING
Malignant Plasma Cell Neoplasms
Qilu Pharmaceutical Co., Ltd.
2026-06 PHASE2
NCT07523737 RECRUITING
Primary Central Nervous System Lymphoma (PCNSL); Diffuse Large B Cell Lymphoma (DLBCL)
Beijing Tongren Hospital
2026-04-01 PHASE2
NCT05137054 RECRUITING
Multiple Myeloma
Regeneron Pharmaceuticals
2022-08-17 PHASE1
NCT06879379 RECRUITING
Multiple Myeloma, Newly Diagnosed
Peking University People's Hospital
2025-03 PHASE2; PHASE3
NCT06948084 NOT_YET_RECRUITING
Recurrent Multiple Myeloma; Refractory Multiple Myeloma
National Cancer Institute (NCI)
2026-08-26 PHASE2
NCT02659930 ACTIVE_NOT_RECRUITING
Kaposi Sarcoma
National Cancer Institute (NCI)
2016-01-13 PHASE1
NCT05651932 RECRUITING
Multiple Myeloma; Myeloma; Myeloma Multiple
K36 Therapeutics, Inc.
2023-02-22 PHASE1
NCT06615479 RECRUITING
Relapsed or Refractory Multiple Myeloma (RRMM)
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
2025-03-12 PHASE3
NCT07441954 NOT_YET_RECRUITING
Indolent Lymphoma
Institute of Hematology & Blood Diseases Hospital, China
2026-03-20 PHASE1; PHASE2
NCT06158841 ACTIVE_NOT_RECRUITING
Multiple Myeloma
AbbVie
2024-05-19 PHASE3
NCT07138209 RECRUITING
Relapsed or Refractory Multiple Myeloma
Qilu Pharmaceutical Co., Ltd.
2025-11-07 PHASE3
NCT06742138 NOT_YET_RECRUITING
Multiple Myeloma
Qilu Pharmaceutical Co., Ltd.
2025-01 PHASE3
NCT07018050 RECRUITING
Relapsed or Refractory Multiple Myeloma
Qilu Pharmaceutical Co., Ltd.
2025-09-12 PHASE2
NCT05208307 RECRUITING
Plasma Cell Myeloma
Emory University
2022-07-21 PHASE2
NCT04850599 ACTIVE_NOT_RECRUITING
Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
OHSU Knight Cancer Institute
2022-06-14 PHASE2
NCT05556798 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Memorial Sloan Kettering Cancer Center
2022-10-04 PHASE1
NCT07532525 RECRUITING
Recurrent B Acute Lymphoblastic Leukemia; Recurrent B-Cell Non-Hodgkin Lymphoma; Refractory B Acute Lymphoblastic Leukemia; Refractory B-Cell Non-Hodgkin Lymphoma
University of Michigan Rogel Cancer Center
2026-09-01 PHASE1
NCT04643002 RECRUITING
Plasma Cell Myeloma Refractory
Sanofi
2021-01-25 PHASE1; PHASE2
NCT04790474 ACTIVE_NOT_RECRUITING
Multiple Myeloma in Relapse; Refractory Multiple Myeloma
Tel-Aviv Sourasky Medical Center
2021-03-25 PHASE2
NCT05451771 ACTIVE_NOT_RECRUITING
AL Amyloidosis
Columbia University
2022-10-26 PHASE1; PHASE2
NCT06106945 RECRUITING
Multiple Myeloma
AstraZeneca
2023-12-05 PHASE1; PHASE2
NCT06464991 RECRUITING
Multiple Myeloma
Nanjing IASO Biotechnology Co., Ltd.
2024-03-27 PHASE3
NCT05455320 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2022-10-13 PHASE3
NCT04124497 ACTIVE_NOT_RECRUITING
Multiple Myeloma; Deletion 17P Syndrome
Fondazione EMN Italy Onlus
2019-07-01 PHASE2
NCT07072208 RECRUITING
Diffuse Large B-Cell Lymphoma
The First Affiliated Hospital of Soochow University
2024-11-01
NCT04176718 ACTIVE_NOT_RECRUITING
Multiple Myeloma; Refractory Multiple Myeloma; Multiple Myeloma in Relapse; Relapse
Andrew Yee, MD
2020-05-18 PHASE2
NCT04108195 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2020-02-21 PHASE1
NCT04835129 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Medical College of Wisconsin
2022-01-10 PHASE2
NCT02343042 RECRUITING
Multiple Myeloma
Karyopharm Therapeutics Inc
2015-10 PHASE1; PHASE2
NCT04068597 RECRUITING
Haematological Malignancy; Acute Myeloid Leukemia; Non Hodgkin Lymphoma; Multiple Myeloma; Higher-risk Myelodysplastic Syndrome; Peripheral T Cell Lymphoma
CellCentric Ltd.
2019-08-09 PHASE1; PHASE2
NCT06508983 RECRUITING
Relapsed/Refractory Multiple Myeloma
Hangzhou Sumgen Biotech Co., Ltd.
2024-06-14 PHASE3
NCT06660498 ACTIVE_NOT_RECRUITING
HIV-1 Infection
University of Aarhus
2025-05-13 PHASE1; PHASE2
NCT04508790 RECRUITING
Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
City of Hope Medical Center
2020-11-24 PHASE2
NCT04661137 SUSPENDED
Multiple Myeloma
Hackensack Meridian Health
2021-03-16 PHASE2
NCT05519085 RECRUITING
Relapsed or Refractory Multiple Myeloma
Celgene
2022-09-20 PHASE3
NCT04270175 ACTIVE_NOT_RECRUITING
Amyloid; AL Amyloidosis; Refractory AL Amyloidosis
Weill Medical College of Cornell University
2021-04-14 PHASE2
NCT06924424 ACTIVE_NOT_RECRUITING
Multiple Myeloma, Neoplasms
Peking University People's Hospital
2025-03-01
NCT04883242 ACTIVE_NOT_RECRUITING
Recurrent Multiple Myeloma; Refractory Multiple Myeloma
University of Washington
2021-07-29 PHASE2
NCT05183139 WITHDRAWN
Multiple Myeloma
Takeda
2022-06-30 PHASE4
NCT04902443 RECRUITING
Viral Associated Malignancies; Kaposi Sarcoma; EBV/KSHV-associated Lymphomas
National Cancer Institute (NCI)
2021-12-10 PHASE1
NCT06855823 RECRUITING
Relapsed/Refractory Peripheral T-Cell Lymphoma (R/R PTCL)
Sun Yat-sen University
2025-01-14 PHASE1; PHASE2
NCT06342466 RECRUITING
Systemic Amyloidosis
Jin Lu, MD
2024-05-06 PHASE2
NCT02718833 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Massachusetts General Hospital
2016-06-21 PHASE2
NCT01562405 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Massachusetts General Hospital
2012-05 PHASE1
NCT04973605 RECRUITING
Relapsed/Refractory Multiple Myeloma
BeOne Medicines
2021-09-16 PHASE1; PHASE2
NCT05581875 NOT_YET_RECRUITING
Multiple Myeloma; Multiple Myeloma in Relapse; Neoplasms; Gammopathy, Monoclonal; Paraproteinemias; Blood Protein Disorders; Haematologic Disease; Corneal Disease; Neoplasms, Plasma Cell
Hellenic Society of Hematology
2022-10-20 PHASE1; PHASE2
NCT04577755 ACTIVE_NOT_RECRUITING
Skin Kaposi Sarcoma
National Cancer Institute (NCI)
2022-03-18 PHASE2
NCT07015021 NOT_YET_RECRUITING
Multiple Myeloma; Carfilzomib; Daratumumab; Pomalidomide
The First Affiliated Hospital of Soochow University
2025-06-01
NCT06554561 RECRUITING
PCNSL
Second Affiliated Hospital, Zhejiang University, School of Medicine
2024-08-31 PHASE1; PHASE2
NCT06152575 RECRUITING
Multiple Myeloma
Pfizer
2024-02-08 PHASE3
NCT03539744 ACTIVE_NOT_RECRUITING
Multiple Myeloma
AbbVie
2018-10-22 PHASE3
NCT04764942 ACTIVE_NOT_RECRUITING
Recurrent Multiple Myeloma; Refractory Multiple Myeloma
Mayo Clinic
2021-05-06 PHASE1; PHASE2
NCT03651128 COMPLETED
Multiple Myeloma
Celgene
2019-04-16 PHASE3
NCT06208150 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2024-01-22 PHASE3
NCT03984097 COMPLETED
Multiple Myeloma
Takeda
2019-07-29 PHASE1
NCT05028348 ACTIVE_NOT_RECRUITING
Multiple Myeloma
European Myeloma Network B.V.
2022-04-19 PHASE3
NCT05066607 UNKNOWN
AL Amyloidosis
Intergroupe Francophone du Myelome
2022-02-11 PHASE2
NCT05020236 RECRUITING
Multiple Myeloma
Pfizer
2021-10-04 PHASE3
NCT02719613 COMPLETED
Multiple Myeloma
Bristol-Myers Squibb
2016-07-15 PHASE2
NCT06484829 RECRUITING
Relapsed or Refractory Multiple Myeloma (RRMM)
Chengdu Zenitar Biomedical Technology Co., Ltd
2024-03-25 PHASE1; PHASE2
NCT06376214 RECRUITING
Light Chain (AL) Amyloidosis
Nanjing University School of Medicine
2023-01-01
NCT04941937 UNKNOWN
Multiple Myeloma
Juan Du
2022-01-27 PHASE2
NCT05050305 WITHDRAWN
Multiple Myeloma; Multiple Myeloma in Relapse; Multiple Myeloma, Refractory
Dana-Farber Cancer Institute
2024-03 PHASE2
NCT06232707 WITHDRAWN
Multiple Myeloma
Celgene
2024-05-03 PHASE3
NCT01665794 COMPLETED
Multiple Myeloma
University of Chicago
2012-08-13 PHASE1; PHASE2
NCT05298683 UNKNOWN
Multiple Myeloma; Renal Impairment; Neoplasms, Plasma Cell; Neoplasms by Histologic Type; Neoplasms; Paraproteinemias; Blood Protein Disorders; Hematologic Diseases
Hellenic Society of Hematology
2022-05 PHASE2
NCT05572515 ACTIVE_NOT_RECRUITING
Relapsed or Refractory Multiple Myeloma
Janssen Research & Development, LLC
2023-03-29 PHASE3
NCT04722146 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2021-03-12 PHASE1
NCT05408026 WITHDRAWN
Relapsed or Refractory Multiple Myeloma
Alliance Foundation Trials, LLC.
2022-10-01 PHASE1; PHASE2
NCT05083169 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2021-10-14 PHASE3
NCT01745588 COMPLETED
Multiple Myeloma
Memorial Sloan Kettering Cancer Center
2012-12 PHASE2
NCT06832228 UNKNOWN
Diffuse Large B-cell Lymphoma (DLBCL)
Zhejiang Cancer Hospital
2024-09-01
NCT02542657 ACTIVE_NOT_RECRUITING
Myeloma
Joseph Tuscano
2015-10 PHASE1; PHASE2
NCT05809180 UNKNOWN
Diffuse Large B Cell Lymphoma
The First Affiliated Hospital of Soochow University
2023-01-04
NCT03590652 TERMINATED
Relapsed/Refractory Multiple Myeloma
University of California, San Diego
2018-10-17 PHASE2
NCT03756896 ACTIVE_NOT_RECRUITING
Plasma Cell Myeloma
Emory University
2019-01-25 PHASE2
NCT05911321 ACTIVE_NOT_RECRUITING
Multiple Myeloma; Relapse; Refractory; Aging; Co-morbidity
UNC Lineberger Comprehensive Cancer Center
2023-12-05 PHASE2
NCT06255847 UNKNOWN
Multiple Myeloma in Relapse
Shanxi Bethune Hospital
2022-06-15 PHASE2
NCT05348213 RECRUITING
Diffuse Large B Cell Lymphoma
Ruijin Hospital
2022-05-16 PHASE2
NCT03715478 ACTIVE_NOT_RECRUITING
Relapsed and/or Refractory Multiple Myeloma
Canadian Myeloma Research Group
2018-11-26 PHASE1; PHASE2
NCT04094961 ACTIVE_NOT_RECRUITING
Multiple Myeloma; Multiple Myeloma in Relapse
Omar Nadeem, MD
2019-09-18 PHASE1; PHASE2
NCT05378971 UNKNOWN
Multiple Myeloma
LanZhou University
2022-05-15
NCT01198067 TERMINATED
Recurrent Waldenstrom Macroglobulinemia; Refractory Waldenstrom Macroglobulinemia
M.D. Anderson Cancer Center
2010-10-06 PHASE1
NCT01946477 COMPLETED
Multiple Myeloma
Celgene
2014-05-29 PHASE2
NCT07150104 ACTIVE_NOT_RECRUITING
Multiple Myeloma
GlaxoSmithKline
2022-08-31 PHASE1; PHASE2
NCT04126200 ACTIVE_NOT_RECRUITING
Multiple Myeloma
GlaxoSmithKline
2019-10-07 PHASE1; PHASE2
NCT04287855 UNKNOWN
Multiple Myeloma in Relapse; Multiple Myeloma, Refractory
Poitiers University Hospital
2020-08-28 PHASE2
NCT05050097 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2021-09-22 PHASE1
NCT05675319 TERMINATED
Multiple Myeloma
Universitätsklinikum Hamburg-Eppendorf
2023-03-03 PHASE3
NCT07694011 COMPLETED
Pomalidomide Bioequivalence Study in Healthy Volunteers
Knight Therapeutics (USA) Inc
2025-01-25 PHASE1
NCT06455748 UNKNOWN
Amyloid Light-chain Amyloidosis
Yongyong MA
2024-03-01
NCT03732703 COMPLETED
Relapsed Refractory Multiple Myeloma
Multiple Myeloma Research Consortium
2019-04-01 PHASE1; PHASE2
NCT04895917 TERMINATED
AL Amyloidosis
Fondazione IRCCS Policlinico San Matteo di Pavia
2021-06-23 PHASE2
NCT03601806 COMPLETED
Human Immunodeficiency Virus 1 Positive; Skin Kaposi Sarcoma
AIDS Malignancy Consortium
2021-04-26 PHASE2
NCT04802161 ACTIVE_NOT_RECRUITING
Acute Myeloid Leukemia; Acute Myeloid Leukemia Post Cytotoxic Therapy; Acute Myeloid Leukemia With Multilineage Dysplasia; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome; Myeloproliferative Neoplasm
National Cancer Institute (NCI)
2022-08-24 PHASE2
NCT06058689 UNKNOWN
Bioequivalence Study
Megalabs
2024-09-15 PHASE1
NCT05405166 ACTIVE_NOT_RECRUITING
Plasma Cell Myeloma Recurrent
Sanofi
2022-06-23 PHASE3
NCT05931328 RECRUITING
Relapsed or Refractory (R/R) Primary Central Nervous System Lymphoma
The First Affiliated Hospital with Nanjing Medical University
2022-10-15 PHASE2
NCT04150965 TERMINATED
Multiple Myeloma; Relapsed Refractory Multiple Myeloma
Multiple Myeloma Research Consortium
2020-07-10 PHASE1; PHASE2
NCT04925193 ACTIVE_NOT_RECRUITING
Multiple Myeloma in Relapse
University of Colorado, Denver
2021-11-18 PHASE2
NCT04989140 UNKNOWN
Multiple Myeloma
Peking Union Medical College Hospital
2021-07-26 PHASE4
NCT05478993 UNKNOWN
Multiple Myeloma
Peking University People's Hospital
2022-10-12 PHASE2
NCT05509374 UNKNOWN
Multiple Myeloma
Samsung Medical Center
2021-10-28 PHASE2
NCT05556616 TERMINATED
Multiple Myeloma
Teva Branded Pharmaceutical Products R&D LLC
2023-01-12 PHASE1
NCT02400242 TERMINATED
Multiple Myeloma
Celgene
2015-05-07 PHASE1
NCT04302324 ACTIVE_NOT_RECRUITING
Multiple Myeloma; Refractory Multiple Myeloma; Relapse Multiple Myeloma
Weill Medical College of Cornell University
2021-10-28 PHASE2
NCT06956170 ACTIVE_NOT_RECRUITING
Multiple Myeloma
GlaxoSmithKline
2022-02-10 PHASE3
NCT04181827 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Janssen Research & Development, LLC
2020-06-12 PHASE3
NCT04892446 TERMINATED
Multiple Myeloma
Gilead Sciences
2021-11-09 PHASE2
NCT03731832 COMPLETED
Refractory Multiple Myeloma
GWT-TUD GmbH
2018-09-20 PHASE2
NCT05390749 UNKNOWN
Primary Central Nervous System Lymphoma
Peking Union Medical College Hospital
2022-04-11 PHASE2
NCT01644110 COMPLETED
Primary Myelofibrosis; Secondary Myelofibrosis; PMF; SMF; Post-PV MF; Post-ET MF
University of Ulm
2013-08 PHASE1; PHASE2
NCT04045795 COMPLETED
Multiple Myeloma
Sanofi
2019-08-06 PHASE1
NCT01997840 TERMINATED
Multiple Myeloma
Celgene
2014-03-01 PHASE1; PHASE2
NCT05288062 TERMINATED
Plasma Cell Myeloma; Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma; Smoldering Plasma Cell Myeloma
Mayo Clinic
2022-06-15 PHASE2
NCT03713294 COMPLETED
Refractory Plasma Cell Myeloma
Mayo Clinic
2019-01-14 PHASE2
NCT05555329 COMPLETED
Multiple Myeloma in Relapse; Multiple Myeloma; Multiple Myeloma, Refractory
Amsterdam UMC, location VUmc
2022-12-01 PHASE4
NCT04484623 ACTIVE_NOT_RECRUITING
Multiple Myeloma
GlaxoSmithKline
2020-10-01 PHASE3
NCT03269136 COMPLETED
Multiple Myeloma
Pfizer
2017-11-29 PHASE1
NCT05432414 UNKNOWN
Multiple Myeloma
RenJi Hospital
2022-12-08 PHASE2
NCT04584307 WITHDRAWN
Multiple Myeloma
Natalie Callendar
2021-04 PHASE2
NCT04700176 TERMINATED
Multiple Myeloma
Hackensack Meridian Health
2022-05-02 PHASE2
NCT04392648 WITHDRAWN
Relapsed and/or Refractory Multiple Myeloma
Teva Branded Pharmaceutical Products R&D LLC
2020-06-24 PHASE1
NCT03582033 TERMINATED
Multiple Myeloma
Seagen Inc.
2018-11-01 PHASE1
NCT03257631 COMPLETED
Central Nervous System Neoplasms; Medulloblastoma
Celgene
2017-09-18 PHASE2
NCT03910244 COMPLETED
Telangiectasia, Hereditary Hemorrhagic
The Cleveland Clinic
2019-10-17 PHASE2
NCT05205252 WITHDRAWN
Relapsed Hematologic Malignancy; Refractory Hematologic Malignancy
Epizyme, Inc.
2021-12-22 PHASE1; PHASE2
NCT04355039 WITHDRAWN
Refractory Multiple Myeloma; Relapse Multiple Myeloma
Medical College of Wisconsin
2021-07-01 PHASE1
NCT03287908 TERMINATED
Relapsed/Refractory Multiple Myeloma
Amgen
2017-11-13 PHASE1
NCT03828292 COMPLETED
Multiple Myeloma
GlaxoSmithKline
2019-03-14 PHASE1
NCT03683277 TERMINATED
Multiple Myeloma; Relapsed and Refractory Multiple Myeloma; Genetic Condition
Intergroupe Francophone du Myelome
2019-11-03 PHASE2
NCT02406222 ACTIVE_NOT_RECRUITING
Multiple Myeloma
University of Leeds
2016-03 PHASE2
NCT04843579 TERMINATED
Myeloma Multiple; Myeloma; Refractory Multiple Myeloma
Weill Medical College of Cornell University
2021-12-29 PHASE2
NCT04191616 COMPLETED
Relapsed or Refractory Multiple Myeloma
Amgen
2020-08-06 PHASE2
NCT02939183 COMPLETED
Relapsed or Refractory Multiple Myeloma
Amgen
2017-01-17 PHASE1
NCT03030261 ACTIVE_NOT_RECRUITING
Multiple Myeloma in Relapse
Washington University School of Medicine
2017-11-22 PHASE2
NCT04162210 ACTIVE_NOT_RECRUITING
Multiple Myeloma
GlaxoSmithKline
2020-04-02 PHASE3
NCT03959358 COMPLETED
Multiple Myeloma; Amyloidosis
University Health Network, Toronto
2020-07-03 PHASE2
NCT03215524 COMPLETED
Multiple Myeloma
Canadian Myeloma Research Group
2017-10-25 PHASE2
NCT04895410 TERMINATED
Multiple Myeloma
AbbVie
2022-01-17 PHASE1
NCT05236621 UNKNOWN
Multiple Myeloma; Recurrent or Refractory
Qilu Pharmaceutical Co., Ltd.
2021-01-04 PHASE3
NCT01495598 COMPLETED
Kaposi Sarcoma; Sarcoma, Kaposi
National Cancer Institute (NCI)
2012-01-10 PHASE1; PHASE2
NCT01734928 COMPLETED
Multiple Myeloma
Celgene
2013-01-07 PHASE3
NCT04667663 ACTIVE_NOT_RECRUITING
Multiple Myeloma
Cancer Trials Ireland
2021-12-08 PHASE1
NCT02726581 COMPLETED
Multiple Myeloma
Bristol-Myers Squibb
2016-08-10 PHASE3
NCT03143985 COMPLETED
Multiple Myeloma
Koen van Besien
2017-07-21 PHASE1
NCT03841565 WITHDRAWN
Recurrent Plasma Cell Myeloma
Academic and Community Cancer Research United
2020-08-07 PHASE2
NCT04762745 UNKNOWN
Relapsed, Refractory, Multiple Myeloma
Sun Yat-sen University
2021-02 PHASE1; PHASE2
NCT03439280 COMPLETED
Relapsed/Refractory; Multiple Myeloma
Millennium Pharmaceuticals, Inc.
2018-04-20 PHASE1; PHASE2
NCT02807454 TERMINATED
Multiple Myeloma
Celgene
2016-07-07 PHASE2
NCT03227432 WITHDRAWN
Multiple Myeloma
Dana-Farber Cancer Institute
2018-12 PHASE2
NCT02004275 UNKNOWN
Multiple Myeloma in Relapse
Alliance for Clinical Trials in Oncology
2014-02 PHASE1; PHASE2
NCT04902443 Recruiting
Viral Associated Malignancies|Kaposi Sarcoma|EBV/KSHV-associated Lymphomas
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
2021-12-10 Phase 1
NCT03657420 WITHDRAWN
Multiple Myeloma
Massachusetts General Hospital
2019-05-30 PHASE1
NCT03015922 UNKNOWN
Multiple Myeloma
University of Leeds
2017-06-05 PHASE1
NCT02283775 COMPLETED
Plasma Cell Myeloma
Sanofi
2015-05-15 PHASE1
NCT03202628 COMPLETED
Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
Mayo Clinic
2017-07-24 PHASE2
NCT02431208 COMPLETED
Multiple Myeloma
Hoffmann-La Roche
2015-07-22 PHASE1
NCT03520985 TERMINATED
Refractory Multiple Myeloma
Swiss Cancer Institute
2018-10-01 PHASE2
NCT03151811 TERMINATED
Multiple Myeloma
Oncopeptides AB
2017-06-12 PHASE3
NCT03798314 COMPLETED
Recurrent Nervous System Lymphoma; Recurrent Primary Vitreoretinal DLBCL; Refractory Nervous System Lymphoma; Refractory Primary Vitreoretinal DLBCL
Mayo Clinic
2019-01-30 PHASE1
NCT02569320 COMPLETED
Recurrent Plasma Cell Myeloma
Ohio State University Comprehensive Cancer Center
2016-05-20 PHASE1
NCT02547662 COMPLETED
Plasma Cell Leukemia; Plasma Cell Myeloma; Plasmacytoma
Mayo Clinic
2015-12-24 PHASE2
NCT02188368 TERMINATED
Multiple Myeloma
Oncotherapeutics
2014-07-07 PHASE2
NCT02963493 COMPLETED
Multiple Myeloma
Oncopeptides AB
2016-12-28 PHASE2
NCT01592370 COMPLETED
Non-Hodgkin's Lymphoma; Hodgkin Lymphoma; Multiple Myeloma
Bristol-Myers Squibb
2012-08-02 PHASE1; PHASE2
NCT02294357 TERMINATED
Multiple Myeloma
Oncotherapeutics
2014-12 PHASE2
NCT03170882 COMPLETED
Relapsed and/or Refractory Multiple Myeloma
Millennium Pharmaceuticals, Inc.
2017-08-01 PHASE2
NCT01421186 COMPLETED
Multiple Myeloma
MorphoSys AG
2011-07 PHASE1; PHASE2
NCT03180736 COMPLETED
Multiple Myeloma
Stichting European Myeloma Network
2017-06-14 PHASE3
NCT01464034 TERMINATED
Multiple Myeloma
Criterium, Inc.
2011-11 PHASE1; PHASE2
NCT03567616 TERMINATED
Multiple Myeloma
AbbVie
2018-10-18 PHASE2
NCT02029950 COMPLETED
Acute Myeloid Leukemia; Chronic Myelomonocytic Leukemia-2; High Risk Myelodysplastic Syndrome; Myeloproliferative Neoplasm
National Cancer Institute (NCI)
2013-12-16 PHASE1
NCT01946152 TERMINATED
Multiple Myeloma-Light Chain Only; Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
M.D. Anderson Cancer Center
2014-03-05 PHASE1; PHASE2
NCT02626481 COMPLETED
Multiple Myeloma
University Hospital, Lille
2015-12-28 PHASE2
NCT03440411 TERMINATED
Multiple Myeloma
Fondazione EMN Italy Onlus
2016-02-18 PHASE3
NCT01712789 COMPLETED
Multiple Myeloma
Celgene
2012-11-06 PHASE3
NCT02661022 TERMINATED
Multiple Myeloma
Stemline Therapeutics, Inc.
2016-01 PHASE1; PHASE2
NCT03104270 TERMINATED
Multiple Myeloma
Oncotherapeutics
2017-03-13 PHASE2
NCT02612779 COMPLETED
Multiple Myeloma
Bristol-Myers Squibb
2016-02-09 PHASE2
NCT02336815 COMPLETED
Multiple Myeloma
Karyopharm Therapeutics Inc
2015-05-26 PHASE2
NCT01497093 COMPLETED
Multiple Myeloma
Celgene
2012-02-15 PHASE1
NCT02415153 COMPLETED
Neurofibromatosis Type 1; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Visual Pathway Glioma; Recurrent Primary Central Nervous System Neoplasm; Refractory Primary Central Nervous System Neoplasm
National Cancer Institute (NCI)
2015-07-14 PHASE1
NCT02287558 COMPLETED
Hereditary Hemorrhagic Telangiectasia; Idiopathic Vascular Ectasia
The Cleveland Clinic
2015-01-27 PHASE1
NCT04243109 TERMINATED
Multiple Myeloma
Maimónides Biomedical Research Institute of Córdoba
2017-02-23 PHASE2
NCT02176213 COMPLETED
Multiple Myeloma in Relapse; Multiple Myeloma, Refractory
Ajai Chari
2014-06 PHASE2
NCT01999335 TERMINATED
Multiple Myeloma
Amgen
2014-07-30 PHASE1
NCT03242460 COMPLETED
Relapsed and/or refractorY Multiple Myeloma
Kosin University Gospel Hospital
2015-05-12 PHASE2
NCT03113942 UNKNOWN
High Grade Squamous Intra-epithelial Lesion (HSIL)
Kirby Institute
2017-06-14 PHASE2
NCT02265510 TERMINATED
Solid Tumors; Advanced Malignancies; Metastatic Cancer
Incyte Corporation
2014-09-10 PHASE1; PHASE2
NCT01998971 COMPLETED
Multiple Myeloma
Janssen Research & Development, LLC
2014-02-18 PHASE1
NCT03601624 UNKNOWN
Multiple Myeloma in Relapse; Multiple Myeloma Progression; Refractory Multiple Myeloma
Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
2018-09-01 PHASE2
NCT02616640 COMPLETED
Multiple Myeloma
Celgene
2016-01-11 PHASE1
NCT02990338 COMPLETED
Plasma Cell Myeloma
Sanofi
2016-12-22 PHASE3
NCT01570387 COMPLETED
AL Amyloidosis
Boston Medical Center
2012-06 PHASE1; PHASE2
NCT01728259 TERMINATED
Light Chain Deposition Disease; Primary Systemic Amyloidosis
Barbara Ann Karmanos Cancer Institute
2013-03 PHASE1
NCT01638936 COMPLETED
Multiple Myeloma
Biotest Pharmaceuticals Corporation
2012-07-03 PHASE1; PHASE2
NCT01575925 COMPLETED
Multiple Myeloma; Renal Impairment
Celgene
2012-06-01 PHASE1
NCT02576977 TERMINATED
Multiple Myeloma
Merck Sharp & Dohme LLC
2015-10-19 PHASE3
NCT02548962 TERMINATED
Multiple Myeloma
Pharmacyclics LLC.
2016-03 PHASE1; PHASE2
NCT03143049 UNKNOWN
Relapse Multiple Myeloma
National University Hospital, Singapore
2017-09-13 PHASE3
NCT02916420 UNKNOWN
Multiple Myeloma
Jiangsu Simcere Pharmaceutical Co., Ltd.
2016-09 PHASE3
NCT00946270 COMPLETED
Polycythemia Vera; Thrombocythemia
M.D. Anderson Cancer Center
2009-07-22 PHASE2
NCT02189343 COMPLETED
Multiple Myeloma
Celgene
2014-09-15 PHASE1
NCT02384083 COMPLETED
Multiple Myeloma
PETHEMA Foundation
2015-09 PHASE1; PHASE2
NCT02158702 UNKNOWN
Multiple Myeloma; Relapse After Use of Lenalidomide and Bortezomib
National University Hospital, Singapore
2014-11 PHASE2
NCT03424928 COMPLETED
Bioequivalence
Jiangsu Simcere Pharmaceutical Co., Ltd.
2018-01-19 PHASE1
NCT02206425 COMPLETED
Multiple Myeloma
Oncotherapeutics
2014-09 PHASE1; PHASE2
NCT02654132 COMPLETED
Multiple Myeloma
Bristol-Myers Squibb
2016-03-18 PHASE2
NCT03023527 TERMINATED
Multiple Myeloma
PETHEMA Foundation
2017-01 PHASE1
NCT02462525 TERMINATED
Multiple Myeloma
AbbVie
2015-05-06 PHASE1
NCT01212952 COMPLETED
Refractory Multiple Myeloma
Mayo Clinic
2011-09 PHASE1; PHASE2
NCT02289222 TERMINATED
Multiple Myeloma
Ashraf Badros
2014-12-30 PHASE1; PHASE2
NCT01688466 COMPLETED
Graft vs Host Disease; Graft-Versus-Host Disease
National Cancer Institute (NCI)
2012-08-30 PHASE2
NCT02045017 COMPLETED
Multiple Myeloma
Celgene
2014-02-28 PHASE2
NCT02578121 WITHDRAWN
Multiple Myeloma
University of Arkansas
2015-12 PHASE2
NCT02244125 COMPLETED
Multiple Myeloma; First Relapse
Institut Curie
2014-04-14 PHASE2
NCT00949364 COMPLETED
Myeloproliferative Neoplasms
University of Ulm
2009-12 PHASE2
NCT01754402 UNKNOWN
Multiple Myeloma
Cristina Gasparetto
2013-01-07 PHASE1; PHASE2
NCT01510613 COMPLETED
Primary Amyloidosis of Light Chain Type
Fondazione IRCCS Policlinico San Matteo di Pavia
2012-02 PHASE2
NCT01541332 UNKNOWN
Multiple Myeloma
Oncotherapeutics
2012-02 PHASE1; PHASE2
NCT01559129 TERMINATED
Scleroderma, Systemic; Sclerosis, Systemic; Systemic Scleroderma; Systemic Sclerosis; Interstitial Lung Disease
Celgene
2012-08-09 PHASE2
NCT01794039 COMPLETED
Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma
Mayo Clinic
2014-03 PHASE2
NCT02103335 COMPLETED
Multiple Myeloma in Relapse; Refractory Multiple Myeloma; Multiple Myeloma
Celgene
2014-06-05 PHASE1
NCT01979276 TERMINATED
Multiple Myeloma
Weill Medical College of Cornell University
2013-11 PHASE1; PHASE2
NCT01522872 UNKNOWN
Multiple Myeloma
Threshold Pharmaceuticals
2012-02 PHASE1; PHASE2
NCT02046915 COMPLETED
Relapsed or Refractory Multiple Myeloma
University Hospital Tuebingen
2014-04 PHASE2
NCT01432600 COMPLETED
Myeloma
H. Lee Moffitt Cancer Center and Research Institute
2011-11 PHASE1; PHASE2
NCT01722305 COMPLETED
B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma; Central Nervous System Lymphoma; Intraocular Lymphoma; Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System; Recurrent Adult Diffuse Large Cell Lymphoma; Retinal Lymphoma
Mayo Clinic
2013-04-08 PHASE1
NCT02119468 COMPLETED
Refractory Plasma Cell Myeloma; Recurrent Plasma Cell Myeloma
City of Hope Medical Center
2014-06-30 PHASE1; PHASE2
NCT02071888 COMPLETED
Non-Hodgkin's Lymphoma (NHL); Multiple Myeloma; Waldenstrom's Macroglobulinemia (WM); Other B-cell NHL Subtypes, Including WM; T-cell NHL
Calithera Biosciences, Inc
2014-02 PHASE1
NCT01807286 TERMINATED
Myeloma
M.D. Anderson Cancer Center
2014-01 PHASE1
NCT01745640 COMPLETED
Multiple Myeloma
University Hospital, Lille
2012-01 PHASE2
NCT01078974 TERMINATED
Waldenstrom's Macroglobulinemia
Steven P. Treon, MD, PhD
2010-05 PHASE1
NCT01568294 COMPLETED
Multiple Myeloma
Celgene
2012-04-01 PHASE1
NCT02185820 COMPLETED
Multiple Myeloma
European Myeloma Network B.V.
2014-06 PHASE1; PHASE2
NCT01889420 TERMINATED
Multiple Myeloma in Relapse
New Mexico Cancer Research Alliance
2014-07 PHASE1
NCT01159574 COMPLETED
Multiple Myeloma
Weill Medical College of Cornell University
2010-08 PHASE2
NCT02228512 WITHDRAWN
Large Cell Lymphoma Arising in KSHV-associated Multicentric Castleman Disease; Primary Effusion Lymphoma
National Cancer Institute (NCI)
2014-08-15 PHASE1; PHASE2
NCT01319422 COMPLETED
Multiple Myeloma
Yale University
2011-06 PHASE2
NCT02168205 COMPLETED
Healthy Volunteers
Celgene
2014-05-30 PHASE1
NCT02011113 COMPLETED
Multiple Myeloma
Celgene Corporation
2013-12 PHASE2
NCT01835561 COMPLETED
Clinical Pharmacology, Healthy Volunteer Study
Celgene
2013-03-01 PHASE1
NCT01324947 COMPLETED
Multiple Myeloma
Celgene
2011-03-01 PHASE3
NCT01053949 COMPLETED
Multiple Myeloma
University Hospital, Lille
2009-10 PHASE2
NCT01537861 TERMINATED
Multiple Myeloma
Washington University School of Medicine
2012-06 EARLY_PHASE1
NCT01986894 COMPLETED
Clinical Pharmacology, Healthy Volunteer Study
Celgene
2013-10-18 PHASE1
NCT01177735 COMPLETED
Multiple Myeloma
University of Arkansas
2011-10 PHASE2
NCT01311687 COMPLETED
Multiple Myeloma
Celgene
2011-03-11 PHASE3
NCT01178281 COMPLETED
Primary Myelofibrosis; MPN-associated Myelofibrosis
Celgene
2010-09-08 PHASE3
NCT01707407 COMPLETED
Pharmacology, Clinical; Healthy
Celgene
2012-09-01 PHASE1
NCT01522547 COMPLETED
Anemia, Sickle Cell
Celgene
2007-08-01 PHASE1
NCT00558896 COMPLETED
Multiple Myeloma and Plasma Cell Neoplasm
Mayo Clinic
2007-11 PHASE2
NCT01474330 COMPLETED
Healthy
Celgene
2011-08-01 PHASE1
NCT01166113 COMPLETED
Multiple Myeloma
Fondazione EMN Italy Onlus
2010-07 PHASE1; PHASE2
NCT00833833 COMPLETED
Multiple Myeloma
Celgene Corporation
2008-06 PHASE1; PHASE2
NCT00537511 TERMINATED
Carcinoma, Small Cell
Celgene
2008-02-01 PHASE1; PHASE2
NCT00770757 COMPLETED
Graft vs Host Disease
Washington University School of Medicine
2009-02 PHASE2
NCT01135199 WITHDRAWN
Pulmonary Fibrosis
Stanford University
2010-04 PHASE2
NCT00463385 COMPLETED
Myelofibrosis With Myeloid Metaplasia; Myeloid Metaplasia; Myelofibrosis
Celgene
2007-04-01 PHASE2
NCT00717522 TERMINATED
Soft Tissue Sarcoma
Celgene
2008-08-01 PHASE2
NCT00540579 COMPLETED
Pancreatic Cancer
SCRI Development Innovations, LLC
2007-11 PHASE1; PHASE2

(data from https://clinicaltrials.gov, updated on 2026-08-14)

Check the Pomalidomide (CC-4047) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Pomalidomide selectively targets the cereblon subunit of the E3 ubiquitin ligase complex and suppresses lipopolysaccharide-induced tumor necrosis factor-alpha release, which leads to cell cycle arrest, apoptosis, and the suppression of tumor angiogenesis alongside enhanced T-cell proliferation. This multimodal immunomodulatory and anti-proliferative activity underpins its therapeutic efficacy in hematologic malignancies such as relapsed or refractory multiple myeloma, Kaposi sarcoma, and diffuse large B-cell lymphoma.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Note: Technical data last updated: Sep 1, 2026.