CAS No. 1303420-67-8
Batch:
Purity:99.08
Chemical Structure
Check the
PLX5622
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-fluoro-N-[(5-fluoro-2-methoxy-3-pyridinyl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine | |
|---|---|---|
| CAS Number | 1303420-67-8 | |
| Molecular Formula |
C21H19F2N5O |
|
| Molecular Weight (MW) | 395.41 | |
| SMILES | CC1=CC2=C(NC=C2CC3=C(N=C(C=C3)NCC4=C(N=CC(=C4)F)OC)F)N=C1 | |
| InChIKey | NSMOZFXKTHCPTQ-UHFFFAOYSA-N |
PLX5622 is a potent and selective colony-stimulating factor 1 receptor (CSF1R) inhibitor. By inhibiting CSF1R kinase activity, PLX5622 disrupts downstream CSF1R signaling pathways essential for microglial survival, proliferation, and maintenance. Administration of PLX5622 induces robust depletion of microglia in the central nervous system, serving as a key tool for investigating microglial functions in neurodegenerative disease models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(126.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
79 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
79 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
79 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- PLX5622 Mechanism of Action: CSF1R Inhibition in Microglia Research
- PLX5622 Clinical Trials
- PLX5622: Selectivity & Specificity
- PLX5622 Working Concentration | Cell Culture | Treatment
- PLX5622 Solubility in DMSO
- PLX5622 Stock Solution
- PLX5622 Storage
- PLX5622 Stability
- PLX5622 Combination Database
- PLX5622 Molecular Weight
- PLX5622 SMILES
- PLX5622 Chemical Structure (2D and 3D)
- PLX5622 Sigma (AMBH93D53574)? Try a better option.
- PLX5622 MedChemExpress (HY-114153)? Try a better option.
- PLX5622 Cayman (28927)? Try a better option.
- PLX5622 Abcam (ab287145)? Try a better option.
- PLX5622 Axonmedchem (Axon 3054)? Try a better option.
- PLX5622 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.