CAS No. 608512-97-6
| IUPAC Name | (8Z)-8-(1H-imidazol-5-ylmethylidene)-6H-pyrrolo[2,3-g][1,3]benzothiazol-7-one | |
|---|---|---|
| CAS Number | 608512-97-6 | |
| Molecular Formula |
C13H8N4OS |
|
| Molecular Weight (MW) | 268.29 | |
| SMILES | C1=CC2=C(C3=C1NC(=O)C3=CC4=CN=CN4)SC=N2 | |
| InChIKey | VFBGXTUGODTSPK-BAQGIRSFSA-N |
PKR-IN-C16 is a potent, cell-permeable small-molecule inhibitor targeting double-stranded RNA-dependent protein kinase (PKR, EIF2AK2). By blocking PKR autophosphorylation, the compound alleviates the translation blockade mediated by eukaryotic initiation factor 2α (eIF2α). Downstream, PKR-IN-C16 suppresses neuroinflammatory signaling pathways, decreasing pro-inflammatory cytokine production including IL-1β and effectively preventing neuronal apoptosis in excitotoxic injury models.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
14 mg/mL
(52.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
13 mg/mL
(48.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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