CAS No. 1628428-01-2
Batch:
Purity:99.91
Chemical Structure
Check the
PKR-IN-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[4-[4-hydroxy-4-(2-methylpropyl)piperidine-1-carbonyl]phenyl]quinoxaline-5-sulfonamide | |
|---|---|---|
| CAS Number | 1628428-01-2 | |
| Molecular Formula |
C24H28N4O4S |
|
| Molecular Weight (MW) | 468.57 | |
| SMILES | CC(C)CC1(O)CCN(CC1)C(=O)C2=CC=C(N[S;v6](=O)(=O)C3=CC=CC4=C3N=CC=N4)C=C2 | |
| InChIKey | JTGUGSWLWPKCGF-UHFFFAOYSA-N |
PKR-IN-2 is a small-molecule allosteric activator targeting the red blood cell pyruvate kinase isoform PKR. Activation of PKR enhances glycolytic flux by facilitating the conversion of phosphoenolpyruvate to pyruvate, thereby increasing cellular adenosine triphosphate (ATP) production. This metabolic enhancement supports erythrocyte energy homeostasis and membrane stability, providing a pathway for investigating PKR function in metabolic and hematologic disorders. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(200.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.