CAS No. 1197160-78-3

Batch: Purity:99.09
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Gedatolisib (PKI-587) Chemical Structure
Chemical Structure
Check the Gedatolisib (PKI-587) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
CAS Number 1197160-78-3
Molecular Formula

C32H41N9O4
Molecular Weight (MW) 615.73
SMILES CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6
InChIKey DWZAEMINVBZMHQ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Gedatolisib (PKI-587) is a potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR. It suppresses the PI3K/AKT/mTOR signaling pathway by inhibiting AKT phosphorylation at T308 and S473. This inhibition leads to PARP cleavage, induction of apoptosis, and suppression of cellular proliferation. Gedatolisib exhibits potent antitumor activity in various human cancer xenograft models, including breast, colon, lung, and glioma tumors. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 3 mg/mL (4.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol 1 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.