CAS No. 903576-44-3

Batch: Purity:99.96
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Pitolisant hydrochloride Chemical Structure
Chemical Structure
Check the Pitolisant hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 903576-44-3
Molecular Formula

C17H27Cl2NO
Molecular Weight (MW) 332.31
SMILES C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl.Cl

Ordering Information

Biological Activity

Pitolisant hydrochloride is a potent, high-affinity competitive antagonist of the human histamine H3 receptor (Ki = 0.16 nM) and acts as an inverse agonist (EC50 = 1.5 nM). By blocking presynaptic H3 autoreceptors, it inhibits autoinhibition of histamine neurons and enhances histaminergic signaling in the central nervous system. This activation increases cortical histamine release and modulates downstream neurotransmitter pathways involved in promoting wakefulness in preclinical models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (198.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 66 mg/mL
Ethanol 66 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.