Clinical Trials

Numerous clinical trials across Phases 1 through 4 evaluate pioglitazone, primarily targeting endocrine and metabolic disorders—including type 2 diabetes mellitus, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, and insulin resistance—as well as renal, oncological, and autoimmune conditions like ANCA-associated vasculitis, prostate cancer, and autoimmune pulmonary alveolar proteinosis. Supported by academic medical centers, government agencies such as the NIDDK, and pharmaceutical sponsors, these studies encompass diverse recruitment statuses ranging from completed and actively recruiting to withdrawn or not yet recruiting.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05838287 RECRUITING
Type 2 Diabetes Mellitus in Obese; Heart Failure With Preserved Ejection Fraction
The University of Texas Health Science Center at San Antonio
 2023-07-10 PHASE4
NCT07635953 NOT_YET_RECRUITING
Diabetes Mellitus
Sun Yat-sen University
 2026-07-01 PHASE3
NCT06246799 RECRUITING
Type 2 Diabetes (Adult Onset)
The University of Texas Health Science Center at San Antonio
 2024-11-07 PHASE3
NCT06946628 NOT_YET_RECRUITING
Diabetes Mellitus
Sun Yat-sen University
 2025-06-01 PHASE3
NCT05946564 RECRUITING
ANCA Associated Vasculitis; Rapidly Progressive Glomerulonephritis; Crescentic Glomerulonephritis
Assistance Publique - Hôpitaux de Paris
 2023-10-24 PHASE3
NCT06336798 RECRUITING
Pulmonary Hypertension; Pulmonary Hypertension Due to Lung Diseases
Emory University
 2024-12-17 PHASE2
NCT02889003 RECRUITING
Chronic Myeloid Leukemia (CML)
Versailles Hospital
 2016-12 PHASE2
NCT07289750 NOT_YET_RECRUITING
T2DM; MAFLD
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
 2026-05-01 PHASE4
NCT04501406 RECRUITING
Type 2 Diabetes Mellitus (T2DM); Nonalcoholic Steatohepatitis
University of Florida
 2020-12-15 PHASE2
NCT05727761 RECRUITING
Oral Leukoplakia
University of Minnesota
 2025-01-01 PHASE2
NCT07053319 RECRUITING
Type 2 Diabetes
The University of Texas Health Science Center at San Antonio
 2026-05-11 PHASE1
NCT07056699 RECRUITING
Type1diabetes
The University of Texas Health Science Center at San Antonio
 2026-07-01 PHASE3
NCT07117630 RECRUITING
Breast Cancer
Fudan University
 2025-09-25 PHASE2
NCT06729996 RECRUITING
Pancreatitis, Chronic; Pancreatitis, Acute; Diabetes Mellitus
Mayo Clinic
 2025-05-29 PHASE2
NCT05305287 RECRUITING
Non-Alcoholic Fatty Liver Disease; Type 2 Diabetes; Mitochondrial Metabolism Disorders
The University of Texas Health Science Center at San Antonio
 2022-11-01 PHASE4
NCT03109288 RECRUITING
Multiple Sclerosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2017-08-11 PHASE1; PHASE2
NCT06135584 NOT_YET_RECRUITING
Metabolic Dysfunction-associated Fatty Liver Disease; Cirrhosis
The Affiliated Hospital of Hangzhou Normal University
 2023-11-18
NCT05753657 RECRUITING
Metastatic Breast Cancer; Hyperinsulinism; Hyperglycemia Drug Induced
Rambam Health Care Campus
 2022-12-25 EARLY_PHASE1
NCT06989723 RECRUITING
Type 2 Diabetes; Fatty Liver
Seoul National University Bundang Hospital
 2025-01-01 PHASE4
NCT06399835 RECRUITING
Type 2 Diabetes
Seoul National University Bundang Hospital
 2024-02-01 PHASE4
NCT03866408 RECRUITING
Obesity
Mayo Clinic
 2018-11-12 EARLY_PHASE1
NCT07604779 ACTIVE_NOT_RECRUITING
Polycystic Ovarian Syndrome (PCOS)
Beni-Suef University
 2026-05-17
NCT02969798 RECRUITING
Diabetes Mellitus, Type 2; Impaired Glucose Tolerance (IGT); Impaired Fasting Glucose (IFG)
The University of Texas Health Science Center at San Antonio
 2014-01-01
NCT05013255 RECRUITING
Breast Cancer; Muscle Fatigue
West Virginia University
 2021-12-23 PHASE2
NCT06972732 RECRUITING
Type 2 Diabetes
Boryung Pharmaceutical Co., Ltd
 2025-06-11 PHASE4
NCT05501483 RECRUITING
Type 2 Diabetes
Karolinska Institutet
 2023-02-08
NCT06922656 NOT_YET_RECRUITING
Type 1 Diabetes
Dasman Diabetes Institute
 2025-09-15 PHASE4
NCT07083401 RECRUITING
Diabete Mellitus
Boryung Pharmaceutical Co., Ltd
 2025-07-05 PHASE1
NCT07083388 RECRUITING
Diabetes Mellitus
Boryung Pharmaceutical Co., Ltd
 2025-07-03 PHASE1
NCT07444424 COMPLETED
Healthy Participants
AstraZeneca
 2026-03-13 PHASE1
NCT05028140 RECRUITING
Type II Diabetes
EMS
 2024-10-08 PHASE3
NCT06851962 COMPLETED
Diabetes Mellitus Type 2
Fundación para la Investigación del Hospital Clínico de Valencia
 2025-05-26 PHASE4
NCT07462065 RECRUITING
Infertility Treatment; Pregnancy Rates
PAEC General Hospital, Islamabad
 2026-03-01 PHASE4
NCT06571591 COMPLETED
T2DM
Celltrion
 2024-08-27 PHASE3
NCT03878459 ACTIVE_NOT_RECRUITING
Type 1 Diabetes Mellitus
The University of Texas Health Science Center at San Antonio
 2019-08-08 PHASE4
NCT07180745 NOT_YET_RECRUITING
Non-alcoholic Fatty Liver Disease NAFLD; Non-alcoholic Steatohepatitis NASH
Badr University
 2025-11-01 PHASE4
NCT06875193 RECRUITING
Type2diabetes
Dong Wha Pharmaceutical Co. Ltd.
 2024-05-28 PHASE4
NCT06594172 NOT_YET_RECRUITING
Radiation Disease; Cognitive Impairment; Drug Effect
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
 2024-09-10 PHASE2
NCT07472179 COMPLETED
PCOS(Insulin Resistant)
Mst.Sumyara Khatun
 2024-08-12
NCT04843046 COMPLETED
Cocaine Use Disorder
The University of Texas Health Science Center, Houston
 2021-08-23 PHASE2
NCT05875675 NOT_YET_RECRUITING
Calcification of Aortic Valve; Aortic Valve Stenosis
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
 2023-07-01 PHASE2
NCT05919147 ACTIVE_NOT_RECRUITING
Lung Cancer
Pennington Biomedical Research Center
 2024-01-03 PHASE2
NCT04370093 COMPLETED
Nephrolithiasis, Uric Acid
University of Texas Southwestern Medical Center
 2019-10-17 PHASE4
NCT05394142 UNKNOWN
Polycystic Ovary Syndrome (PCOS)
Fundació Sant Joan de Déu
 2022-05-24 PHASE2
NCT04300127 COMPLETED
Gastroparesis
Johns Hopkins University
 2019-10-24 EARLY_PHASE1
NCT03452267 WITHDRAWN
Insulin Sensitivity
Wayne State University
 2019-09-01 PHASE2; PHASE3
NCT06107153 COMPLETED
Type2diabetes
University of Basrah
 2023-11-01 PHASE3
NCT07083232 COMPLETED
Diabetic; Myocardial Infarction
Al-Azhar University
 2024-10-30 PHASE4
NCT04794127 COMPLETED
Liposarcoma, Myxoid; Liposarcoma, Dedifferentiated; Liposarcoma, Round Cell
Mario Negri Institute for Pharmacological Research
 2022-02-02 PHASE2
NCT04271189 COMPLETED
Newly Diagnosed Type 2 Diabetes
Azienda Ospedaliero-Universitaria di Parma
 2020-09-01 PHASE3
NCT05107765 COMPLETED
Alcohol Use Disorder
The University of Texas Health Science Center, Houston
 2022-05-12 PHASE1; PHASE2
NCT05775380 UNKNOWN
Myocardial Reperfusion Injury
University of Campinas, Brazil
 2023-06-15 PHASE4
NCT05942963 UNKNOWN
Non-Alcoholic Fatty Liver Disease; Type2diabetes
Jinnah Postgraduate Medical Centre
 2023-10 PHASE4
NCT03864146 COMPLETED
Alcohol Use Disorder
VA Office of Research and Development
 2019-07-17
NCT02852486 COMPLETED
Leukemia, Chronic Myeloid
University of Campinas, Brazil
 2016-06-22 PHASE2
NCT05254626 COMPLETED
Non-alcoholic Steatohepatitis
Cairo University
 2022-08-01 PHASE2
NCT03499704 COMPLETED
Diabetes Mellitus, Type 2
Celltrion Pharm, Inc.
 2020-02-11 PHASE4
NCT05659459 TERMINATED
COVID-19
Kinarus AG
 2022-08-25 PHASE2
NCT02879409 ACTIVE_NOT_RECRUITING
Diabetes Mellitus Type 2
Weill Cornell Medical College in Qatar
 2016-11
NCT05760677 UNKNOWN
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries; T2D
Affiliated Hospital of Nantong University
 2022-10-01 PHASE1
NCT03720366 COMPLETED
Leukemia, Myeloid, Acute
Celgene
 2018-10-04 PHASE1
NCT04419337 UNKNOWN
Diabetes Mellitus; Stroke
Chang Gung Memorial Hospital
 2019-09-15 PHASE2
NCT06164665 COMPLETED
High Altitude
United States Army Research Institute of Environmental Medicine
 2023-03-01 PHASE4
NCT05946564 Not yet recruiting
ANCA Associated Vasculitis|Rapidly Progressive Glomerulonephritis|Crescentic Glomerulonephritis
Assistance Publique - Hôpitaux de Paris|Ministry of Health France
 2023-07 Phase 3
NCT05629806 UNKNOWN
Type 2 Diabetes; Blood Glucose Fluctuation
Nanjing First Hospital, Nanjing Medical University
 2022-04-10 PHASE3
NCT04976283 UNKNOWN
Diabetes Mellitus, Type 2; NASH - Nonalcoholic Steatohepatitis; NAFLD
Getz Pharma
 2021-09-15 PHASE4
NCT05605158 UNKNOWN
Non Alcoholic Steatohepatitis
Tanta University
 2022-11 PHASE3
NCT04658849 WITHDRAWN
Insulin Resistance; Prostate Cancer
St. Louis University
 2020-12-02 EARLY_PHASE1
NCT01107717 COMPLETED
Diabetes
The University of Texas Health Science Center at San Antonio
 2009-01 PHASE4
NCT05473806 UNKNOWN
Hepatitis B, Chronic; Fibrosis, Liver; Diabetes Mellitus, Type 2
Seung Up Kim
 2020-09-18 PHASE4
NCT04995978 WITHDRAWN
Prostate Cancer; Insulin Resistance
St. Louis University
 2021-12-01 PHASE2
NCT05519813 UNKNOWN
Polycystic Ovary Syndrome
Bing He
 2022-01-01 PHASE4
NCT05422092 UNKNOWN
Type 2 Diabetes Mellitus With Complication
First Affiliated Hospital Xi'an Jiaotong University
 2022-09-20
NCT04662866 UNKNOWN
Impaired Glucose Tolerance; Insulin Sensitivity; Glucose Metabolism Disorders
Oslo University Hospital
 2021-02-10 PHASE2
NCT05591235 UNKNOWN
Type2diabetes; Insulin Resistance
Nanjing First Hospital, Nanjing Medical University
 2022-11 PHASE3
NCT02767063 UNKNOWN
Leukemia, Myeloid, Chronic-Phase
Versailles Hospital
 2016-07 PHASE1; PHASE2
NCT05305287 Recruiting
Non-Alcoholic Fatty Liver Disease|Type 2 Diabetes|Mitochondrial Metabolism Disorders
The University of Texas Health Science Center at San Antonio|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2022-11-01 Phase 4
NCT04657939 COMPLETED
Diabetes Mellitus, Type 2
University of Leeds
 2020-12-01 PHASE4
NCT02535832 COMPLETED
Rheumatoid Arthritis; Insulin Resistance
Ohio State University
 2015-09 PHASE1
NCT04885712 COMPLETED
Type2 Diabetes
Boryung Pharmaceutical Co., Ltd
 2021-05-28 PHASE3
NCT03646292 COMPLETED
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease; Type 2 Diabetes; Digestive System Disease; Liver Diseases; Fatty Liver; Metabolic Dysfunction-Associated Steatotic Liver Disease; Non-Alcoholic Fatty Liver Disease; Hypoglycemic Agents; Physiological Effects of Drugs; Sodium-Glucose Cotransporter 2 Inhibitors; Pioglitazone; Molecular Mechanisms of Pharmacological Action; Empagliflozin; Thiazolidinediones
Yonsei University
 2018-12-06 PHASE4
NCT04584242 UNKNOWN
Chronic Hepatitis B With Significant Hepatic Fibrosis With Type 2 Diabetes
Yonsei University
 2020-09-03 PHASE4
NCT05411965 Completed
Diabetes Mellitus Type 2
Boryung Pharmaceutical Co. Ltd
 2022-04-28 Phase 1
NCT02315287 UNKNOWN
Type 2 Diabetes
Seoul National University Bundang Hospital
 2014-09 PHASE4
NCT04535700 COMPLETED
Type 2 Diabetes
Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
 2020-09-18 PHASE4
NCT03794518 UNKNOWN
Risk Reduction
Hamad Medical Corporation
 2019-03 PHASE3
NCT04867252 COMPLETED
PCOS
Khyber Medical University Peshawar
 2021-05-03 PHASE2
NCT02823808 UNKNOWN
Diabetes
Kyunghee University Medical Center
 2017-07 PHASE4
NCT04604223 UNKNOWN
Covid19; Type 2 Diabetes
Dasman Diabetes Institute
 2021-01-18 PHASE4
NCT04883125 COMPLETED
Chronic Myelogenous Leukemia, BCR-ABL Positive; CML, Chronic Phase
Mansoura University
 2018-01-01 PHASE2
NCT04123067 TERMINATED
Stroke, Acute; Hyperglycemia; Diabetes
Milton S. Hershey Medical Center
 2020-09-01 PHASE1; PHASE2
NCT04287387 UNKNOWN
Type2 Diabetes Mellitus
Peking Union Medical College Hospital
 2020-03-02 PHASE4
NCT03566225 COMPLETED
Pioglitazone
Ain Shams University
 2018-01-30 EARLY_PHASE1
NCT05521633 COMPLETED
NAFLD
King Edward Medical University
 2019-06-06 PHASE3
NCT02653209 COMPLETED
Type 2 Diabetes
Royal Devon and Exeter NHS Foundation Trust
 2016-11-01 PHASE4
NCT03440034 COMPLETED
Myositis; Inclusion Body Myositis; Muscular Diseases; Musculoskeletal Disease; Neuromuscular Diseases; Nervous System Diseases
Johns Hopkins University
 2018-05-22 PHASE1
NCT03950505 UNKNOWN
Non-alcoholic Steatohepatitis; Type2 Diabetes
Yonsei University
 2020-05-29 PHASE4
NCT04501406 Recruiting
Type 2 Diabetes Mellitus (T2DM)|Nonalcoholic Steatohepatitis
University of Florida|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2020-12-15 Phase 2
NCT04473274 COMPLETED
Coronavirus Infection; Diabetes
Samaritan Health Services
 2020-05-21 PHASE4
NCT04392557 UNKNOWN
Diabetes Mellitus, Type 2
University of Catanzaro
 2020-07-01 PHASE4
NCT04535700 Completed
Type 2 Diabetes
Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
 2020-09-18 Phase 4
NCT02338999 COMPLETED
Systemic Lupus Erythematosus
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
 2015-06-18 PHASE1; PHASE2
NCT03910361 COMPLETED
Type2 Diabetes; Non-Alcoholic Fatty Liver Disease
Dong-A ST Co., Ltd.
 2019-04-12 PHASE4
NCT02942758 TERMINATED
Acute Myeloid Leukemia
University Hospital Regensburg
 2017-04-10 PHASE2
NCT04113889 COMPLETED
PCOS
Khyber Medical University Peshawar
 2019-10-15 PHASE2
NCT03060772 TERMINATED
Alcoholism
Emory University
 2018-01-03 PHASE2
NCT03471117 TERMINATED
Chronic Kidney Diseases
The University of Texas at Arlington
 2018-04-01 PHASE4
NCT03080480 TERMINATED
Chronic Granulomatous Disease
Children's Hospital of Fudan University
 2017-09-01 PHASE1; PHASE2
NCT02697617 COMPLETED
Polycystic Kidney Disease
Indiana University
 2016-01-26 PHASE2
NCT00904046 Recruiting
Uric Acid Kidney Stone Disease
University of Texas Southwestern Medical Center|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Takeda Pharmaceuticals North America Inc.
 2019-09-05 Not Applicable
NCT02917629 TERMINATED
Oral Cavity Neoplasm; Oropharyngeal Neoplasm; Stage 0 Oral Cavity Squamous Cell Carcinoma American Joint Committee on Cancer (AJCC) v6 and v7; Stage 0 Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7; Stage I Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage I Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7; Stage II Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage II Oropharyngeal Squamous Cell Carcinoma AJCC v6 and v7; Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7
National Cancer Institute (NCI)
 2018-05-31 PHASE2
NCT03860753 TERMINATED
Alcohol Use Disorder
The University of Texas Health Science Center, Houston
 2019-03-01 PHASE1; PHASE2
NCT02852083 UNKNOWN
Squamous Cell Lung Cancer; Non-Squamous Cell Lung Cancer; Non-Small Cell Lung Cancer
University Hospital Regensburg
 2016-01 PHASE2
NCT04470310 UNKNOWN
Type 2 Diabetes Mellitus
Seoul National University Hospital
 2015-12-31 PHASE4
NCT03796975 COMPLETED
Type 2 Diabetes Mellitus; Non-alcoholic Fatty Liver Disease; Efficacy
Xijing Hospital
 2018-06-28 PHASE4
NCT03231033 COMPLETED
Autoimmune Pulmonary Alveolar Proteinosis
Children's Hospital Medical Center, Cincinnati
 2017-08-17 PHASE1
NCT03864523 COMPLETED
Adrenomyeloneuropathy; X-linked Adrenoleukodystrophy
Pujol, Aurora, M.D.
 2016-01 PHASE2
NCT02919176 COMPLETED
Obese; Metabolic Syndrome
Philip Kern
 2016-09-01 EARLY_PHASE1
NCT02763007 TERMINATED
Diabetes Mellitus, Type 2
Kun-Ho Yoon
 2016-05-18 PHASE4
NCT03757923 UNKNOWN
Menstrual Irregularities; Hyperandrogenism
Dow University of Health Sciences
 2018-06-18 PHASE1; PHASE2
NCT04671056 COMPLETED
Healthy
Madrigal Pharmaceuticals, Inc.
 2018-11-09 PHASE1
NCT00700856 UNKNOWN
Type 2 Diabetes Mellitus; Cardiovascular Disease
Italian Society of Diabetology
 2008-09 PHASE4
NCT01471808 COMPLETED
Diabetes Mellitus, Type 2
Sun Yat-sen University
 2011-10 PHASE4
NCT02689843 COMPLETED
Polycystic Ovary Syndrome
Shiraz University of Medical Sciences
 2018-02-01 EARLY_PHASE1
NCT02231021 COMPLETED
Type 2 Diabetes Mellitus
Kun-Ho Yoon
 2014-09 PHASE4
NCT03196362 UNKNOWN
Type 2 Diabetes Mellitus
Sun Yat-sen University
 2016-12-01 PHASE4
NCT02694263 COMPLETED
Diabetes Mellitus, Type 2
University of Leicester
 2016-07 PHASE4
NCT01931566 TERMINATED
Mild Cognitive Impairment Due to Alzheimer's Disease
Takeda
 2013-08-01 PHASE3
NCT03501277 COMPLETED
Healthy Volunteers
Takeda
 2018-05-26 PHASE1
NCT03298464 COMPLETED
Obese
NGM Biopharmaceuticals, Inc
 2017-09-11 PHASE1
NCT02347813 COMPLETED
Squamous Cell Carcinoma of the Skin
University of Rochester
 2014-11 PHASE2
NCT03335956 COMPLETED
Healthy
Corcept Therapeutics
 2017-09-21 PHASE1
NCT01135394 COMPLETED
Type 2 Diabetes
University of Maryland, Baltimore
 2009-03
NCT02787551 COMPLETED
Type 2 Diabetes Mellitus
Sanofi
 2016-07-06 PHASE3
NCT03457597 COMPLETED
Healthy
Corcept Therapeutics
 2018-03-06 PHASE1
NCT02585765 WITHDRAWN
Spinal Cord Injury; Pressure Ulcers
James J. Peters Veterans Affairs Medical Center
 2017-02-01 PHASE2
NCT02284906 TERMINATED
Mild Cognitive Impairment Due to Alzheimer's Disease
Takeda
 2015-02-12 PHASE3
NCT00904046 COMPLETED
Uric Acid Kidney Stone Disease
University of Texas Southwestern Medical Center
 2010-01-15
NCT02303405 TERMINATED
Diabetes Mellitus Type 2 With Hyperglycemia
Charles Drew University of Medicine and Science
 2014-11 PHASE2
NCT01838317 COMPLETED
Cancer of the Pancreas
University of Texas Southwestern Medical Center
 2013-05 PHASE2
NCT02733679 COMPLETED
Ataxia-Telangiectasia
NHS Tayside
 2016-09-29 PHASE4
NCT03117517 COMPLETED
Polycystic Ovarian Syndrome
Khyber Medical University Peshawar
 2017-03-20 EARLY_PHASE1
NCT02429232 UNKNOWN
Osteoporosis; Diabetes Mellitus
National Taiwan University Hospital
 2015-10 PHASE4
NCT02875821 COMPLETED
Type 2 Diabetes With Non-alcoholic Fatty Liver (NAFLD)
Yonsei University
 2016-04-26 PHASE4
NCT02887625 UNKNOWN
Type 2 Diabetes
Dr. Muhammad Abdulghani
 2015-02
NCT03125694 COMPLETED
Uncontrolled Type 2 Diabetes Mellitus
Tehran University of Medical Sciences
 2015-02-01 PHASE3
NCT00212004 TERMINATED
Diabetes Mellitus; Myocardial Infarction
National Cerebral and Cardiovascular Center, Japan
 2005-04 PHASE4
NCT01655719 COMPLETED
Thyroid Cancers That Contain the PAX8-PPARgamma Fusion Gene
University of Michigan
 2012-04 PHASE2
NCT02365233 TERMINATED
Type II Diabetes; Nonalcoholic Fatty Liver
The University of Texas Medical Branch, Galveston
 2013-05-01 PHASE4
NCT01748994 COMPLETED
Obesity; Metabolic Syndrome
Pennington Biomedical Research Center
 2011-02
NCT02592317 ACTIVE_NOT_RECRUITING
Prostatic Neoplasms, Castration-Resistant
Aragon Pharmaceuticals, Inc.
 2016-02-12 PHASE1
NCT02687425 UNKNOWN
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Meng Li
 2016-02 PHASE2
NCT02753803 COMPLETED
Type 2 Diabetes
Dong-A ST Co., Ltd.
 2016-07-27 PHASE1
NCT01972724 COMPLETED
Type II Diabetes Mellitus
Takeda
 2013-12-16 PHASE4
NCT01002547 COMPLETED
Nonalcoholic Steatohepatitis
VA Office of Research and Development
 2010-06-24 PHASE4
NCT02195791 TERMINATED
Stroke
Taipei Medical University Shuang Ho Hospital
 2014-07 PHASE2
NCT00994175 COMPLETED
Severe, Refractory Asthma; Airway Inflammation; Airflow Obstruction
National Heart, Lung, and Blood Institute (NHLBI)
 2009-09-23 PHASE2
NCT00780234 COMPLETED
Lung Cancer; Endobronchial Dysplasia
VA Office of Research and Development
 2009-08 PHASE2
NCT01352182 COMPLETED
Severe Sepsis; Septic Shock
Children's Hospital Medical Center, Cincinnati
 2011-10 PHASE1; PHASE2
NCT02133625 COMPLETED
Advanced Solid Tumor; Metastatic Solid Tumor
Dana-Farber Cancer Institute
 2011-08 PHASE1
NCT01717040 TERMINATED
Bipolar Disorder; Insulin Resistance
University Hospitals Cleveland Medical Center
 2012-09 PHASE4
NCT01301027 COMPLETED
End Stage Renal Disease
University of Utah
 2008-05
NCT02426294 UNKNOWN
Type 2 Diabetes Mellitus
Pusan National University Hospital
 2015-02 PHASE4
NCT00091949 COMPLETED
Stroke; Myocardial Infarction; Diabetes
Yale University
 2005-02 PHASE3
NCT02072096 TERMINATED
Diabetes Mellitus, Type 2
Eli Lilly and Company
 2014-02 PHASE4
NCT02142309 UNKNOWN
Type 2 Diabetes
University of Campania Luigi Vanvitelli
 2005-10 PHASE4
NCT01631630 TERMINATED
Alcohol Dependence; Alcohol Drinking; Stress; Alcohol-Related Disorders
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 2012-05 PHASE2
NCT02265276 UNKNOWN
Fatty Liver
Command Hospital, India
 2014-10 PHASE3
NCT01205282 COMPLETED
Autism Spectrum Disorders
Evdokia Anagnostou
 2013-04 PHASE2
NCT02371603 COMPLETED
Anaemia
GlaxoSmithKline
 2015-02-11 PHASE1
NCT02341703 COMPLETED
Polycystic Ovary Syndrome; Infertility
Cairo University
 2015-02 EARLY_PHASE1
NCT02473627 COMPLETED
Healthy
Daiichi Sankyo
 2015-05 PHASE1
NCT01947790 COMPLETED
LVM; Type 2 Diabetic Patients With IHD; Endothelial Function
Xiang Guang-da
 2013-09 PHASE4
NCT00427999 COMPLETED
Prostate Cancer
Novartis Pharmaceuticals
 2007-02 PHASE2
NCT02683226 COMPLETED
Polycystic Ovary Syndrome; Insulin Resistance
University Medical Centre Ljubljana
 2015-03 PHASE4
NCT02774343 COMPLETED
Cocaine Use Disorder; Alcohol Use Disorder
The University of Texas Health Science Center, Houston
 2012-08 PHASE1; PHASE2
NCT02342067 COMPLETED
Healthy
Tobira Therapeutics, Inc.
 2014-12 PHASE1
NCT00815399 COMPLETED
Type 2 Diabetes
University of Campania Luigi Vanvitelli
 2007-10 PHASE4
NCT01517165 TERMINATED
Opioid-Related Disorders
National Institute on Drug Abuse (NIDA)
 2012-01-04 PHASE1
NCT03030300 COMPLETED
Type2 Diabetes
Qianfoshan Hospital
 2008-01 PHASE4
NCT01817400 COMPLETED
Infertility, Female; Obesity
University of Colorado, Denver
 2013-03 EARLY_PHASE1
NCT02236962 UNKNOWN
Type 2 Diabetes; Obesity; Cardiovascular Disease
Bayside Health
 2012-04
NCT00994682 COMPLETED
Nonalcoholic Steatohepatitis; Nonalcoholic Fatty Liver Disease; Type 2 Diabetes Mellitus
University of Florida
 2008-12 PHASE4
NCT02222441 COMPLETED
Healthy
Pfizer
 2014-10 PHASE1
NCT00745225 COMPLETED
End-stage Renal Disease
The University of Hong Kong
 2006-02 PHASE4
NCT01703260 TERMINATED
Nonalcoholic Steatohapatitis
AstraZeneca
 2013-06 PHASE2
NCT01151670 COMPLETED
Brain Neoplasms, Malignant; Brain Neoplasms, Benign; Malignant Meningioma; Glioblastoma Multiforme; Anaplastic Astrocytoma
Wake Forest University Health Sciences
 2010-08 PHASE1
NCT02192684 COMPLETED
Insulin Sensitivity; Obstructive Sleep Apnea
Stanford University
 2010-09
NCT01895569 UNKNOWN
Type 2 Diabetes Mellitus
University of Pavia
 2013-06 PHASE4
NCT03011775 COMPLETED
Adverse Effect; Atherosclerosis, Coronary; Insulin Resistance Syndrome
Ukrainian Medical Stomatological Academy
 2012-11 PHASE4
NCT01280123 COMPLETED
Parkinson's Disease
University of Rochester
 2011-03 PHASE2
NCT01614301 UNKNOWN
Advanced Melanoma
University of Regensburg
 2012-05 PHASE1; PHASE2
NCT01395797 TERMINATED
Heroin Dependence; Nicotine Dependence
New York State Psychiatric Institute
 2011-03 PHASE1; PHASE2
NCT00951379 TERMINATED
Oral Leukoplakia
National Cancer Institute (NCI)
 2010-02 PHASE2
NCT01174056 COMPLETED
Lung Inflammation
Washington University School of Medicine
 2011-07 EARLY_PHASE1
NCT01909141 COMPLETED
Polycystic Ovary Syndrome; Infertility
Cairo University
 2013-08 EARLY_PHASE1
NCT01157975 WITHDRAWN
Hepatitis C
University of California, San Diego
 2008-10 PHASE2
NCT01559857 COMPLETED
Major Depressive Disorder; Insulin Resistance
Stanford University
 2011-11 PHASE4
NCT01695707 WITHDRAWN
Atopic Dermatitis
University of Rochester
 2013-03
NCT01935804 COMPLETED
Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucose Metabolism Disorders
King Abdulaziz University
 2009-01 PHASE2
NCT01395784 COMPLETED
Opioid Abuse
New York State Psychiatric Institute
 2010-08 PHASE2
NCT00782795 COMPLETED
Chronic Pancreatitis; Insulin Resistance; Normal or Mildly Abnormal Stool Fat Levels
University of Michigan
 2008-11 PHASE2
NCT00855010 COMPLETED
Obesity; Type 2 Diabetes
University of Texas Southwestern Medical Center
 2009-02
NCT02099838 COMPLETED
Diabetes Mellitus, Type 2
Huazhong University of Science and Technology
 2012-01 PHASE4
NCT00736996 COMPLETED
Mild Cognitive Impairment
University of Colorado, Denver
 2008-11 PHASE2
NCT01010243 UNKNOWN
Multiple Myeloma
University of Regensburg
 2009-10 PHASE1; PHASE2
NCT00745914 COMPLETED
Endstage Renal Disease; Diabetes
The University of Hong Kong
 2008-09
NCT01186250 COMPLETED
Cardiac Allograft Vasculopathy
Stanford University
 2010-07 PHASE2
NCT01289639 TERMINATED
Fatty Liver
VA Office of Research and Development
 2005-10
NCT01454336 COMPLETED
Liver Fibrosis
Royan Institute
 2010-06 PHASE1
NCT01873001 COMPLETED
Healthy Volunteers
Janssen Research & Development, LLC
 2013-05 PHASE1
NCT00787644 TERMINATED
Asthma; Obesity
University of Vermont
 2009-01 PHASE2
NCT01819402 UNKNOWN
To Evaluate the Effect of Pioglitazone on Glucose Metabolism of Fat Tissue by Using FDG-PET/CT Imaging
Kurume University
 2012-03
NCT00835120 COMPLETED
Metabolic Syndrome; Bipolar Depression; Insulin Resistance
University Hospitals Cleveland Medical Center
 2009-03 PHASE4
NCT00827892 COMPLETED
Intracerebral Hemorrhage
The University of Texas Health Science Center, Houston
 2009-03 PHASE2
NCT01095666 COMPLETED
Type 2 Diabetes
AstraZeneca
 2010-06 PHASE3
NCT00811681 COMPLETED
Friedreich's Ataxia
Assistance Publique - Hôpitaux de Paris
 2008-12 PHASE3
NCT01963663 COMPLETED
Type 2 Diabetes Mellitus
Tehran University of Medical Sciences
 2012-11
NCT01882907 COMPLETED
Type 2 Diabetes
Pusan National University Hospital
 2009-12 PHASE4
NCT01183013 COMPLETED
Diabetes Mellitus, Type 2
Boehringer Ingelheim
 2010-08 PHASE3
NCT01331967 COMPLETED
Diabetic Stable Angina; Diabetic Unstable Angina
Korea University Anam Hospital
 2011-02 PHASE4
NCT00408850 UNKNOWN
Metabolic Syndrome
Baker Heart Research Institute
 2008-11 PHASE3
NCT00742326 TERMINATED
HIV; Hepatitis C; Liver Disease; Fatty Liver; Steatosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2008-08 PHASE4
NCT02292290 COMPLETED
Type 2 Diabetes
University of Leicester
 2011-04 PHASE4
NCT01025765 UNKNOWN
Chronic Hepatitis C
National Taiwan University Hospital
 2009-11 PHASE4
NCT00399204 WITHDRAWN
Type 2 Diabetes
Post Graduate Institute of Medical Education and Research, Chandigarh
 2006-01 PHASE4
NCT01342770 TERMINATED
Stage IA Non-Small Cell Lung Carcinoma; Stage IB Non-Small Cell Lung Carcinoma; Stage IIA Non-Small Cell Lung Carcinoma; Stage IIB Non-Small Cell Lung Carcinoma; Stage IIIA Non-Small Cell Lung Cancer
National Cancer Institute (NCI)
 2011-04 PHASE2
NCT00470262 COMPLETED
Metabolic Syndrome X; Prediabetic State
VA Office of Research and Development
 2007-01
NCT01175486 UNKNOWN
Diabetes
Taipei Veterans General Hospital, Taiwan
 2010-07 PHASE4
NCT01339143 UNKNOWN
Diabetes Mellitus; Oxidative Stress
Korea University Anam Hospital
 2010-04 PHASE4
NCT01175824 COMPLETED
Diabetes Mellitus, Type 2
Eli Lilly and Company
 2011-04 PHASE4
NCT00554853 COMPLETED
Rheumatoid Arthritis
University of Michigan
 2007-11 PHASE3
NCT01431521 COMPLETED
Non-alcoholic Fatty Liver Disease
Merck Sharp & Dohme LLC
 2011-10-26 PHASE1
NCT00763139 COMPLETED
Rheumatoid Arthritis
Vanderbilt University
 2009-04
NCT01147627 COMPLETED
Diabetes Mellitus, Type 2; Newly Diagnosed
Sun Yat-sen University
 2010-08
NCT00927290 TERMINATED
Chronic Hepatitis C; Insulin Resistance
French National Agency for Research on AIDS and Viral Hepatitis
 2009-12-03 PHASE3
NCT01043029 COMPLETED
Diabetes Mellitus Type 2
Hoffmann-La Roche
 2010-05 PHASE2
NCT00789750 COMPLETED
Type 2 Diabetes Mellitus
Daiichi Sankyo
 2009-04 PHASE3
NCT01456117 COMPLETED
Healthy
Takeda
 2011-11 PHASE1
NCT01341730 TERMINATED
Atherosclerosis; Coronary Artery Disease
The Catholic University of Korea
 2011-06 PHASE4
NCT01184144 WITHDRAWN
Endometriosis
University of Wisconsin, Madison
 2010-08 PHASE2; PHASE3
NCT00545857 COMPLETED
Type 1 Diabetes Mellitus
Stony Brook University
 2002-06 PHASE1
NCT01225081 COMPLETED
Type 2 Diabetes Mellitus
Astellas Pharma Inc
 2010-09-15 PHASE3
NCT01210001 COMPLETED
Diabetes Mellitus, Type 2
Boehringer Ingelheim
 2010-09 PHASE3
NCT01106131 COMPLETED
Type 2 Diabetes Mellitus
Chong Kun Dang Pharmaceutical
 2010-05 PHASE3
NCT00634036 COMPLETED
Asthma
Fernando Holguin
 2009-10 PHASE2
NCT00996658 COMPLETED
Diabetes Mellitus, Type 2
Boehringer Ingelheim
 2009-10 PHASE3
NCT00953498 COMPLETED
Type 2 Diabetes
Centre Hospitalier Universitaire Dijon
 2007-10 PHASE4
NCT01570660 COMPLETED
Type 2 Diabetes Mellitus
German Diabetes Center
 2002-02
NCT02027103 COMPLETED
Type 2 Diabetes Mellitus
Tehran University of Medical Sciences
 2012-01
NCT01911728 COMPLETED
Pharmacokinetics of MDV3100; Castration Resistant Prostate Cancer (CRPC)
Astellas Pharma Europe B.V.
 2011-07-25 PHASE1
NCT00867126 TERMINATED
Pancreatic Cancer
University of Texas Southwestern Medical Center
 2009-03-02 EARLY_PHASE1
NCT02888964 COMPLETED
Leukemia, Myeloid, Chronic-Phase
Versailles Hospital
 2009-12 PHASE2
NCT01217073 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
 2010-10-08 PHASE2
NCT01322308 COMPLETED
Systemic Lupus Erythematosus
National Heart Institute, Mexico
 2007-03 PHASE4
NCT00839527 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
 2009-02 PHASE3
NCT01223196 COMPLETED
Type 2 Diabetes
The University of Texas Health Science Center at San Antonio
 2009-08 PHASE4
NCT01289119 COMPLETED
Diabetes Mellitus, Type 2
Takeda
 2010-12 PHASE3
NCT01588470 COMPLETED
Type 2 Diabetes; Coronary Heart Disease
The University of Texas Health Science Center at San Antonio
 2006-06 PHASE4
NCT00232583 COMPLETED
Type 2 Diabetes Mellitus
University of Texas Southwestern Medical Center
 2003-11
NCT01006018 TERMINATED
Prediabetic State
Emory University
 2011-07
NCT01489943 COMPLETED
Crohn's Disease
GlaxoSmithKline
 2011-09-19 PHASE1
NCT00849056 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
 2009-01 PHASE3
NCT00846716 UNKNOWN
Type 2 Diabetes Mellitus
Shiga University
 2008-03
NCT01064687 COMPLETED
Diabetes Mellitus, Type 2
Eli Lilly and Company
 2010-02 PHASE3
NCT01103414 COMPLETED
Type 2 Diabetes
Metabolic Solutions Development Company
 2010-09 PHASE2
NCT01346254 COMPLETED
Impaired Glucose Tolerance; Kidney Transplantation
Marcus Saemann
 2009-12 PHASE2
NCT01106690 COMPLETED
Diabetes Mellitus, Type 2
Janssen Research & Development, LLC
 2010-06 PHASE3
NCT02305069 COMPLETED
Obesity; Sarcopenia
University of Nottingham
 2009-10
NCT01195090 COMPLETED
Type 2 Diabetes
Sung-Chen Liu
 2009-10 PHASE4
NCT01109030 COMPLETED
Major Depressive Disorder
Tehran University of Medical Sciences
 2010-04 PHASE2; PHASE3
NCT01040819 COMPLETED
Type 2 Diabetes Mellitus
Baylor College of Medicine
 2010-02 PHASE4
NCT01593371 COMPLETED
Type 2 Diabetes Mellitus
Tehran University of Medical Sciences
 2011-07
NCT00671515 COMPLETED
Depressive Disorder, Major; Metabolic Syndrome X
Joseph Calabrese, MD
 2008-04 PHASE2
NCT00633282 COMPLETED
Nonalcoholic Fatty Liver Disease
Xin Gao
 2008-03 PHASE2
NCT01076075 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
 2010-06-03 PHASE3
NCT00179400 COMPLETED
Type 2 Diabetes Mellitus
Albert Einstein College of Medicine
 2000-12 PHASE4
NCT00868140 TERMINATED
Polycystic Ovary Syndrome
Virginia Commonwealth University
 2009-02
NCT01026194 COMPLETED
Type 2 Diabetes Mellitus
Tanabe Pharma Corporation
 2009-12 PHASE3
NCT00694759 COMPLETED
Polycystic Ovary Syndrome
Oregon Health and Science University
 2006-10
NCT01253928 UNKNOWN
ESRD
Centre Hospitalier Universitaire Vaudois
 2007-03 PHASE4
NCT01230749 COMPLETED
Diabetes Mellitus, Type 2
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2010-12 PHASE2
NCT00926614 COMPLETED
Hepatitis c
Brooke Army Medical Center
 2008-09 PHASE4
NCT00763815 COMPLETED
Diabetes Mellitus Type 2
Sanofi
 2008-09 PHASE3
NCT01280695 COMPLETED
Diabetes Mellitus, Type 2
Metabolic Solutions Development Company
 2011-02 PHASE2
NCT01276327 COMPLETED
Healthy
Boehringer Ingelheim
 2011-01 PHASE1
NCT00362440 COMPLETED
HIV Lipodystrophy
Beth Israel Deaconess Medical Center
 2006-08 PHASE2
NCT00770835 COMPLETED
Diabetes Mellitus
Takeda
 2009-03 PHASE4
NCT00665353 COMPLETED
HIV-1 and Hepatitis C Co-Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2009-03 PHASE2
NCT00843791 TERMINATED
Obesity; Insulin Resistance
Oregon Health and Science University
 2009-02
NCT00708175 COMPLETED
Bone Metabolism
Takeda
 2008-05 PHASE4
NCT00775164 WITHDRAWN
Obesity; Insulin Resistance
University of Minnesota
 2009-01 PHASE4
NCT00376870 UNKNOWN
Coronary Atherosclerosis; Coronary Restenosis; Diabetes
University of Rome Tor Vergata
 2008-07 PHASE3
NCT00736099 COMPLETED
Diabetes Mellitus, Type 2
Boehringer Ingelheim
 2008-08 PHASE3
NCT00885352 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
 2009-04-15 PHASE3
NCT00656864 COMPLETED
Diabetes Mellitus, Type 2
University of Vermont
 2008-05 PHASE4
NCT00879970 TERMINATED
Diabetes Mellitus, Type 2
GlaxoSmithKline
 2009-05 PHASE4
NCT00153166 COMPLETED
Arterial Occlusive Disease; Intermittent Claudication; Insulin Resistance
Brigham and Women's Hospital
 2004-01 PHASE2; PHASE3
NCT00744367 COMPLETED
Diabetes Mellitus Type 2
Hoffmann-La Roche
 2008-10 PHASE3
NCT00972283 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
 2009-09-01 PHASE3
NCT00722371 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
 2008-09-05 PHASE3
NCT01028963 COMPLETED
Type 2 Diabetes Mellitus
Amgen
 2010-01 PHASE2
NCT00927355 COMPLETED
Osteoblast; Adipocytes; Bone Density; Osteocalcin; Adiponectin; Mesenchymal Stem Cells
Emory University
 2009-04
NCT01115712 COMPLETED
Healthy; Overweight; Obesity
Merck Sharp & Dohme LLC
 2010-05 PHASE1
NCT01156597 COMPLETED
Type 2 Diabetes Mellitus
University of Miami
 2008-04 PHASE3
NCT01009580 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
 2009-11-05 PHASE3
NCT01089790 TERMINATED
Diabetes Mellitus, Type 2
Forest Laboratories
 2010-03 PHASE3
NCT00443755 COMPLETED
Type 2 Diabetes; Insulin Resistance; Metabolic Syndrome
Mayo Clinic
 2005-08 PHASE2
NCT00300365 COMPLETED
Metabolic Syndrome
University of Pennsylvania
 2005-11 PHASE2
NCT00970424 TERMINATED
Diabetes Mellitus, Type II
Forest Laboratories
 2009-08 PHASE3
NCT00845182 COMPLETED
Type 2 Diabetes; Healthy; Impaired Glucose Tolerance
The University of Texas Health Science Center at San Antonio
 2007-06 PHASE4
NCT00770445 COMPLETED
Diabetes Mellitus
Takeda
 2008-05 PHASE4
NCT02172235 COMPLETED
Healthy
Boehringer Ingelheim
 2010-04 PHASE1
NCT00676338 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
 2008-11 PHASE3
NCT00991055 UNKNOWN
Type 2 Diabetes
National Cheng-Kung University Hospital
 2008-05 PHASE4
NCT00861341 COMPLETED
Diabetes; Platelet Function; Healthy
University of Rochester
 2008-12 PHASE2
NCT00770640 COMPLETED
Diabetes Mellitus
Takeda
 2008-08 PHASE2
NCT00690118 TERMINATED
Amyotrophic Lateral Sclerosis
University of Ulm
 2008-05 PHASE2
NCT01023620 COMPLETED
HIV Infections
University of Texas Southwestern Medical Center
 2009-10
NCT00825266 TERMINATED
Hypertension, Pulmonary
Stanford University
 2008-09 PHASE2
NCT01082120 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
 2010-02 PHASE1
NCT00220961 COMPLETED
Impaired Glucose Tolerance; Type 2 Diabetes
The University of Texas Health Science Center at San Antonio
 2004-01 PHASE3
NCT00485056 COMPLETED
Diabetes
Imperial College London
 2008-04 PHASE4
NCT01088594 COMPLETED
Type 2 Diabetes Mellitus
Solvay Pharmaceuticals
 2010-02 PHASE1
NCT01800240 COMPLETED
Healthy
Torrent Pharmaceuticals Limited
 PHASE1
NCT00926016 COMPLETED
Chronic Hepatitis C
Brooke Army Medical Center
 2006-06
NCT01800227 COMPLETED
Healthy
Torrent Pharmaceuticals Limited
 PHASE1
NCT00541450 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
 2008-01-15 PHASE3
NCT00231894 COMPLETED
Diabetes; Schizophrenia; Insulin Resistance; Cognitive Impairment
Nathan Kline Institute for Psychiatric Research
 2005-05 PHASE4
NCT00683878 COMPLETED
Type 2 Diabetes
AstraZeneca
 2008-07 PHASE3
NCT02183636 COMPLETED
Healthy
Boehringer Ingelheim
 2009-08 PHASE1
NCT01088919 COMPLETED
Healthy; Pharmacokinetics of ASP1941
Astellas Pharma Inc
 2009-11 PHASE1
NCT00655863 COMPLETED
Diabetes Mellitus
Takeda
 2007-07 PHASE3
NCT00749047 UNKNOWN
Diabetes Mellitus, Type 2
Christchurch Hospital
 2008-09 PHASE4
NCT01589445 COMPLETED
Type 2 Diabetes Mellitus
University of Dhaka
 2008-11 PHASE4
NCT00770367 COMPLETED
Diabetes
Medical University of South Carolina
 2008-10 PHASE4
NCT00919555 COMPLETED
Amyotrophic Lateral Sclerosis
Phoenix Neurological Associates, LTD
 2008-06 PHASE1; PHASE2
NCT00680745 COMPLETED
Type 2 Diabetes
AstraZeneca
 2008-04 PHASE3
NCT00604578 WITHDRAWN
Asthma; Airway Inflammation; Airflow Obstruction; Airway Hyperactivity
National Heart, Lung, and Blood Institute (NHLBI)
 2008-01-04 PHASE2
NCT00532935 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
 2008-01-26 PHASE3
NCT00780715 COMPLETED
Diabetes Mellitus, Type 2
University of Dundee
 2008-12 PHASE4
NCT00507494 COMPLETED
Diabetes Mellitus; Kidney Transplantation; Proteinuria
Technische Universität Dresden
 2007-07 PHASE3
NCT00656851 COMPLETED
HIV Infections; Cardiovascular Disease; Insulin Resistance; HIV Lipodystrophy; The Metabolic Syndrome
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2005-09
NCT00631007 COMPLETED
Type 2 Diabetes Mellitus
InteKrin Therapeutics, Inc.
 2008-02 PHASE2
NCT01318122 COMPLETED
Type 2 Diabetes Mellitus
Takeda
 2008-05 PHASE2; PHASE3
NCT00515632 COMPLETED
Diabetes Mellitus, Type 2
Rheoscience A/S
 2007-07 PHASE3
NCT02276365 COMPLETED
Healthy
Boehringer Ingelheim
 2009-06 PHASE1
NCT00641043 COMPLETED
Diabetes Mellitus, Type 2
Boehringer Ingelheim
 2008-03 PHASE3
NCT00719381 COMPLETED
Cystic Fibrosis
Paul Beringer
 2008-01 PHASE1
NCT00063622 COMPLETED
Liver Diseases
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2005-01 PHASE3
NCT01001013 COMPLETED
Healthy
LG Life Sciences
 2009-02 PHASE1
NCT00432276 COMPLETED
Diabetes Mellitus
Takeda
 2007-01 PHASE3
NCT00770653 COMPLETED
Diabetes Mellitus; Dyslipidemias
Takeda
 2007-04 PHASE3
NCT00722917 TERMINATED
Diabetes Mellitus
Takeda
 2008-07 PHASE2
NCT00722631 COMPLETED
Impaired Glucose Tolerance; Type 2 Diabetes Mellitus; Atherosclerosis
Kurume University
 2007-05
NCT00511108 COMPLETED
Type 2 Diabetes Mellitus (T2DM)
Merck Sharp & Dohme LLC
 2007-07-11 PHASE1
NCT00484198 COMPLETED
Type 2 Diabetes Mellitus
Daiichi Sankyo
 2007-04-23 PHASE3
NCT00637273 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
 2008-01 PHASE3
NCT00771004 COMPLETED
Oxidative Stress; Coronary Artery Disease; Type 2 Diabetes
Takeda
 2006-08 PHASE2
NCT00062764 COMPLETED
Hepatitis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2003-06 PHASE2
NCT00531882 COMPLETED
Cystic Fibrosis
University Hospitals Cleveland Medical Center
 2007-09
NCT01028391 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
 2007-09-01 PHASE3
NCT00760578 COMPLETED
Type 2 Diabetes Mellitus
Metabolic Solutions Development Company
 2008-09 PHASE2
NCT00586261 TERMINATED
Chronic Kidney Disease
Mayo Clinic
 2006-03
NCT00579813 COMPLETED
Metabolic Syndrome; Insulin Resistance; Prediabetes
Philip Kern
 2005-04 PHASE4
NCT00437970 WITHDRAWN
Diabetes Mellitus, Type 2
Menzies School of Health Research
 2008-04 PHASE4
NCT00770952 COMPLETED
Diabetes Mellitus
Takeda
 2006-12 PHASE3
NCT00395941 COMPLETED
Psoriasis
Post Graduate Institute of Medical Education and Research, Chandigarh
 2006-12 PHASE2
NCT00681733 UNKNOWN
Metabolic Parameters and Liver Histology
Govind Ballabh Pant Hospital
 2007-01
NCT00639457 COMPLETED
HIV Infections; Type 2 Diabetes; Obesity; HIV; AIDS; Cardiovascular Disease; Lipodystrophy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2005-01
NCT00570622 COMPLETED
Cirrhosis; Ascites; Portal Hypertension
Medical University of Vienna
 2004-12 PHASE4
NCT01318070 COMPLETED
Type 2 Diabetes Mellitus
Takeda
 2007-11 PHASE2; PHASE3
NCT00441272 COMPLETED
HIV Infections; Hepatic Steatosis; Insulin Resistance
National Institute of Allergy and Infectious Diseases (NIAID)
 2007-02 PHASE2
NCT01798940 COMPLETED
Healthy
Torrent Pharmaceuticals Limited
 PHASE1
NCT01258322 COMPLETED
Peritoneal Dialysis; Pioglitazone; Hypertriglyceridemia; Insulin Resistance; Inflammation
Huashan Hospital
 2008-01
NCT01797666 COMPLETED
Healthy
Torrent Pharmaceuticals Limited
 PHASE1
NCT00727857 COMPLETED
Diabetes Mellitus
Takeda
 2007-06 PHASE3
NCT00494559 COMPLETED
Diabetes Mellitus; Coronary Artery Stenosis
Korea University Anam Hospital
 2007-07 PHASE4
NCT01432405 COMPLETED
Type 2 Diabetes Mellitus
Baylor College of Medicine
 2007-06 PHASE4
NCT00397631 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
 2006-12-19 PHASE3
NCT00099021 COMPLETED
Head and Neck Cancer; Oral Leukoplakia
National Cancer Institute (NCI)
 2003-06 PHASE2
NCT00203996 TERMINATED
Polycystic Ovary Syndrome; Obstructive Sleep Apnea
University of Chicago
 2003-09 PHASE4
NCT00926341 COMPLETED
Metabolic Syndrome
Aligarh Muslim University
 2006-10 PHASE4
NCT00575874 COMPLETED
Type 2 Diabetes
Daiichi Sankyo Co., Ltd.
 2007-08 PHASE2
NCT00571519 TERMINATED
Type 2 Diabetes Mellitus
Daiichi Sankyo
 2007-11-14 PHASE3
NCT00770497 COMPLETED
Inflammation; Hypertension
Takeda
 2007-03 PHASE2
NCT00411892 TERMINATED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
 2006-11-29 PHASE3
NCT00328627 COMPLETED
Type 2 Diabetes Mellitus
Takeda
 2006-05 PHASE3
NCT00500331 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
 2007-01-23 PHASE2
NCT00372060 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
 2006-08-21 PHASE3
NCT00772174 COMPLETED
Diabetes Mellitus
Takeda
 2007-01 PHASE3
NCT00395512 COMPLETED
Diabetes Mellitus
Takeda
 2006-11 PHASE3
NCT00099853 COMPLETED
Diabetes Mellitus, Type 2
Novartis Pharmaceuticals
 2004-05 PHASE3
NCT00189163 COMPLETED
Chronic Hepatitis C
University of Michigan
 2005-01 PHASE4
NCT00433069 COMPLETED
Chronic Hepatitis C
University Hospital, Geneva
 2007-01 PHASE2
NCT00402012 COMPLETED
Diabetes Mellitus, Type 2
Pennington Biomedical Research Center
 2006-11 PHASE4
NCT00598013 COMPLETED
Kidney Transplantation; Insulin Resistance; Atherosclerosis
Yonsei University
 2004-11
NCT00327015 COMPLETED
Diabetes
AstraZeneca
 2006-05 PHASE3
NCT00295633 COMPLETED
Diabetes Mellitus, Type 2
AstraZeneca
 2006-03 PHASE3
NCT00225277 COMPLETED
Diabetes Mellitus
Takeda
 2003-07 PHASE3
NCT01090752 COMPLETED
Diabetes; Hypertension
University Hospital, Geneva
 2005-10 PHASE4
NCT00368017 TERMINATED
Chronic Kidney Disease
Vanderbilt University
 2006-04 PHASE2
NCT00286494 COMPLETED
Diabetes Mellitus
Takeda
 2006-02 PHASE3
NCT00571506 COMPLETED
Diabetes Mellitus, Type 2; Vascular Diseases
University of Arkansas
 2004-05 PHASE4
NCT00543959 TERMINATED
Diabetes Mellitus Type 2
Merck Sharp & Dohme LLC
 2006-06 PHASE2
NCT00402909 COMPLETED
Type 2 Diabetes
Novartis Pharmaceuticals
 2006-11 PHASE4
NCT00720577 COMPLETED
Peripheral Arterial Disease
Medtronic Endovascular
 2005-12 EARLY_PHASE1
NCT00297063 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
 2006-01-11 PHASE3
NCT01124656 TERMINATED
Diabetes Mellitus, Type 2
Takeda
 2006-09 PHASE3
NCT00376181 TERMINATED
Type 2 Diabetes
Takeda
 2006-06 PHASE3
NCT02183337 COMPLETED
Healthy
Boehringer Ingelheim
 2007-02 PHASE1
NCT00196989 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
 2005-09 PHASE2
NCT00315146 COMPLETED
Obesity; Overweight With Indications for Weight Loss
Wake Forest University Health Sciences
 2006-04 PHASE4
NCT00108615 COMPLETED
Glucose Metabolism Disorders; Diabetes
US Department of Veterans Affairs
 2004-01 PHASE4
NCT00737347 COMPLETED
Type 2 Diabetes; Obesity
Northwestern University
 2003-09 PHASE3
NCT00328393 COMPLETED
Hypertension; Diabetes Mellitus Type 2
University of Erlangen-Nürnberg Medical School
 2007-03 PHASE3
NCT00237237 COMPLETED
Diabetes Mellitus, Type 2
Novartis
 2005-10 PHASE3
NCT00145340 COMPLETED
Polycystic Ovary Syndrome
Odense University Hospital
 2002-09 PHASE4
NCT00609856 COMPLETED
Type 2 Diabetes; Secondary Drug Failure
Skane University Hospital
 2004-04 PHASE4
NCT00226330 TERMINATED
Diabetes Mellitus, Type 2
AstraZeneca
 2005-03 PHASE3
NCT00322868 COMPLETED
Cystic Fibrosis
University Hospitals Cleveland Medical Center
 2006-04
NCT00819325 COMPLETED
Coronary Artery Disease; Angina Pectoris; Type 2 Diabetes Mellitus; Percutaneous Coronary Intervention
Queen Elizabeth II Health Sciences Centre
 2002-08 PHASE4
NCT00754403 COMPLETED
Diabetes Mellitus
Takeda
 2005-07 PHASE4
NCT00214565 TERMINATED
Diabetes Mellitus, Type 2
AstraZeneca
 2004-08 PHASE3
NCT01396564 COMPLETED
Type 2 Diabetes
Coordinación de Investigación en Salud, Mexico
 2005-10 PHASE1; PHASE2
NCT00121667 COMPLETED
Diabetes Mellitus, Type 2
AstraZeneca
 2005-08 PHASE3
NCT00770575 COMPLETED
Cardiovascular Diseases
Takeda
 2005-06 PHASE2
NCT00106808 COMPLETED
Type 2 Diabetes Mellitus
Bristol-Myers Squibb
 2005-08 PHASE3
NCT00816218 COMPLETED
Type 2 Diabetes Mellitus
The University of Texas Health Science Center at San Antonio
 2003-03 PHASE4
NCT00138554 COMPLETED
Diabetes Mellitus, Type 2
Novartis
 2004-11 PHASE3
NCT00229684 TERMINATED
Diabetes Mellitus, Type 2
AstraZeneca
 2004-09 PHASE2
NCT00106704 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
 2005-03 PHASE3
NCT00225264 COMPLETED
Diabetes Mellitus
Takeda
 2003-10 PHASE3
NCT00101803 COMPLETED
Diabetes Mellitus, Type 2
Novartis Pharmaceuticals
 2005-01 PHASE3
NCT00364988 COMPLETED
Type 2 Diabetes; Diabetic Nephropathy
Shanghai Jiao Tong University School of Medicine
 2005-01
NCT00143520 COMPLETED
Type 2 Diabetes
Daiichi Sankyo
 2004-12 PHASE2; PHASE3
NCT00227110 COMPLETED
Nonalcoholic Steatohepatitis
The University of Texas Health Science Center at San Antonio
 2002-10 PHASE4
NCT00086502 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
 2004-06 PHASE3
NCT00308373 COMPLETED
Diabetes Mellitus, Type 2
Mayo Clinic
 2004-07
NCT00762736 COMPLETED
Diabetes Mellitus
Takeda
 2004-07 PHASE2
NCT00094757 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
 2004-10-06 PHASE3
NCT00097279 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
 2004-08 PHASE3
NCT00086515 COMPLETED
Diabetes Mellitus, Type II
Merck Sharp & Dohme LLC
 2004-06-30 PHASE3
NCT00494312 COMPLETED
Diabetes Mellitus; Liver
Takeda
 2000-10 PHASE4
NCT00240370 COMPLETED
Type 2 Diabetes
Bristol-Myers Squibb
 2003-10 PHASE3
NCT00982202 COMPLETED
Alzheimer Disease
National Institute on Aging (NIA)
 2002-01 PHASE2
NCT00676260 COMPLETED
Diabetes Mellitus
Takeda
 2002-12 PHASE2
NCT00672919 COMPLETED
Diabetes Mellitus
Takeda
 2003-11 PHASE4
NCT00331487 COMPLETED
Diabetes Mellitus
Takeda
 2000-09 PHASE3
NCT01799850 COMPLETED
Diabetes Type 2
East Tennessee State University
 2002-03 PHASE4
NCT00598793 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
 2002-11 PHASE3
NCT00521820 TERMINATED
Diabetes Mellitus
Takeda
 2000-06 PHASE3
NCT00649012 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2003-03 PHASE1
NCT00649558 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2003-02 PHASE1
NCT00521742 COMPLETED
Diabetes Mellitus
Takeda
 2001-03 PHASE3
NCT00189774 COMPLETED
Type 2 Diabetes Mellitus; Diabetes Mellitus, Type II
Astellas Pharma Inc
 PHASE2; PHASE3
NCT00459940 COMPLETED
Growth Hormone Deficiency
University of Aarhus
 2004-09
NCT00482183 COMPLETED
Coronary Artery Disease; Type 2 Diabetes Mellitus
Showa University
 2003-07 PHASE2; PHASE3
NCT00576784 COMPLETED
Type 2 Diabetes Mellitus; Insulin Resistance
IKFE Institute for Clinical Research and Development
 2005-04 PHASE4
NCT00242177 COMPLETED
Multiple Sclerosis, Relapsing-Remitting
University of Illinois at Chicago
 2003-10 PHASE1
NCT00276497 COMPLETED
Diabetes
M.V. Hospital for Diabetes
 2003-10 PHASE1
NCT00151710 COMPLETED
Congenital Adrenal Hyperplasia
Radboud University Medical Center
NCT00384215 COMPLETED
Diabetes Mellitus, Type 2
Sanofi
 2001-12 PHASE4
NCT00314561 COMPLETED
Metabolic Syndrome
Korea University Anam Hospital
 2006-05 PHASE4
NCT00352287 COMPLETED
Obesity; Metabolic Syndrome; Impaired Glucose Tolerance
Stanford University
 2003-03 PHASE4
NCT00479986 COMPLETED
Type 2 Diabetes Mellitus; Cardiovascular Disease
IKFE Institute for Clinical Research and Development
 2005-06 PHASE4
NCT00155350 UNKNOWN
Coronary Atherosclerosis; Inflammation; Coronary Heart Disease
National Taiwan University Hospital
 2004-11 PHASE4
NCT00232362 WITHDRAWN
Type 2 Diabetes Mellitus
Texas Tech University Health Sciences Center
 2007-06 PHASE1
NCT00269061 COMPLETED
Non-Insulin-Dependent Diabetes Mellitus
GlaxoSmithKline
 2006-01 PHASE1
NCT00013598 COMPLETED
Fatty Liver; Nonalcoholic Steatohepatitis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2001-03 PHASE2
NCT00159211 TERMINATED
Type 2 Diabetes
Assistance Publique - Hôpitaux de Paris
 2005-05
NCT00154037 COMPLETED
Healthy Subjects
Technische Universität Dresden
 2005-10
NCT00212290 COMPLETED
Insulin Resistance; Type 2 Diabetes Mellitus
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2002-11 PHASE4
NCT00148850 TERMINATED
HIV-Associated Lipodystrophy Syndrome; HIV Infections
French National Agency for Research on AIDS and Viral Hepatitis
 2003-02 PHASE3
NCT00290940 COMPLETED
Diabetes Mellitus, Type 2
Daiichi Sankyo
 2006-01 PHASE2
NCT00377975 COMPLETED
Obesity
Pennington Biomedical Research Center
 2003-01 PHASE2
NCT00015626 COMPLETED
Insulin Resistance; Diabetes Mellitus
National Center for Research Resources (NCRR)
 PHASE2
NCT01161394 COMPLETED
Inflammation
University at Buffalo
 PHASE4
NCT00306826 WITHDRAWN
Glucose Metabolism Disorders
University of Leipzig
 PHASE4

(data from https://clinicaltrials.gov, updated on 2025-08-27)

Check the Pioglitazone HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Pioglitazone hydrochloride functions as a selective peroxisome proliferator-activated receptor-gamma agonist and cytochrome P450 inhibitor, suppressing mitochondrial iron uptake and subsequent lipid peroxidation. This activation modulates downstream transcriptional programs controlling lipid and glucose homeostasis to prevent cell ferroptosis, underpinning its clinical application in managing metabolic disorders like type 2 diabetes mellitus and nonalcoholic steatohepatitis.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.