CAS No. 39012-20-9

Batch: Purity:99.71
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Picroside II Chemical Structure
Chemical Structure
Check the Picroside II product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 39012-20-9
Molecular Formula

C23H28O13
Molecular Weight (MW) 512.46
SMILES COC1=C(C=CC(=C1)C(=O)OC2C3C=COC(C3C4(C2O4)CO)OC5C(C(C(C(O5)CO)O)O)O)O

Biological Activity

Picroside II is a naturally occurring iridoid glycoside with antioxidant, anti-inflammatory, and neuroprotective activities. It attenuates oxidative stress and suppresses inflammatory cascades by inhibiting the NF-κB and MAPK signaling pathways. Downstream, Picroside II reduces the expression of pro-inflammatory cytokines, lowers intracellular reactive oxygen species (ROS) levels, and inhibits apoptotic pathways, thereby mitigating tissue damage and cellular dysfunction in various preclinical models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (195.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.