CAS No. 4408-78-0
Batch:
Purity:98.91
Chemical Structure
Check the
Phosphonoacetic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-phosphonoacetic acid | |
|---|---|---|
| CAS Number | 4408-78-0 | |
| Molecular Formula |
C2H5O5P |
|
| Molecular Weight (MW) | 140.03 | |
| SMILES | OC(=O)C[P](O)(O)=O | |
| InChIKey | XUYJLQHKOGNDPB-UHFFFAOYSA-N |
Phosphonoacetic acid is an active endogenous metabolite and antiviral compound that selectively inhibits herpes simplex virus DNA polymerase through interaction with its pyrophosphate binding site. By specifically blocking viral DNA biosynthesis without impairing host cellular DNA polymerase activity, it effectively halts viral genomic replication and suppresses herpesvirus infection and proliferation. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
28 mg/mL
(199.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 28 mg/mL |
| Ethanol | 28 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Phosphonoacetic acid Clinical Trials
- Phosphonoacetic acid Solubility in DMSO
- Phosphonoacetic acid Stock Solution
- Phosphonoacetic acid Storage
- Phosphonoacetic acid Stability
- Phosphonoacetic acid Molecular Weight
- Phosphonoacetic acid SMILES
- Phosphonoacetic acid Chemical Structure (2D and 3D)
- Phosphonoacetic acid SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.