CAS No. 1078-21-3

Batch: Purity:99.04
Check CoA
Phenibut (β-Phenyl-GABA) Chemical Structure
Chemical Structure
Check the Phenibut (β-Phenyl-GABA) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-amino-3-phenylbutanoic acid
CAS Number 1078-21-3
Molecular Formula

C10H13NO2
Molecular Weight (MW) 179.22
SMILES C1=CC=C(C=C1)C(CC(=O)O)CN
InChIKey DAFOCGYVTAOKAJ-UHFFFAOYSA-N

Biological Activity

Phenibut is a central nervous system depressant and GABA analogue that acts as an agonist at GABAB receptors and an inhibitor of voltage-gated calcium channels containing α2δ subunits. By activating GABAB receptor signaling and dampening presynaptic calcium influx, it reduces excitatory neurotransmitter release in neural circuits. This attenuation of central excitability mediates pronounced anxiolytic, sedative, and neuroprotective downstream phenotypes in central nervous system pathways. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 36 mg/mL (200.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 36 mg/mL
Ethanol 36 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Lapin I. CNS Drug Rev. 2001;7(4):471-81.

[2] Dambrova M, et al. Eur J Pharmacol. 2008;583(1):128-34.

Jump to

Note: Technical data last updated: Sep 1, 2026.