CAS No. 1110813-31-4

Batch: Purity:99.84
Check CoA
Dacomitinib (PF-299804) Chemical Structure
Chemical Structure
Check the Dacomitinib (PF-299804) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
CAS Number 1110813-31-4
Molecular Formula

C24H25ClFN5O2
Molecular Weight (MW) 469.94
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)C=CCN4CCCCC4
InChIKey LVXJQMNHJWSHET-AATRIKPKSA-N

Ordering Information

Biological Activity

Dacomitinib is a potent, irreversible pan-ErbB receptor tyrosine kinase inhibitor targeting EGFR, ERBB2, and ERBB4. It effectively inhibits wild-type EGFR, EGFR-activating mutations, and the EGFR T790M resistance mutation in preclinical tumor models. By suppressing ErbB receptor autophosphorylation and downstream RAS/MAPK and PI3K/AKT signaling pathways, dacomitinib inhibits cell growth and induces apoptosis. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 49 mg/mL (104.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 15 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.