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PF-07220060 (CDK4/6-IN-6) SDS | MSDS
1.PRODUCT AND COMPANY IDENTIFICATION
Product identifier
- Product Name: PF-07220060 (CDK4/6-IN-6)
- Catalog Number: E1495
- CAS Number: 2380321-51-5
- IUPAC Name: D-threo -Pentitol, 1,5-anhydro-3-[[5-chloro-4-[4-fluoro-2-(1-hydroxy- 1-methylethyl)-1-(1-methylethyl)-1H -benzimidazol-6-yl]-2-pyrimi dinyl]amino]-2,3-dideoxy
Relevant identified uses and uses advised against
- Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
- Uses advised against: Not for pharmaceutical, household, or other unapproved uses.
Details of the supplier
- Company : Selleck Chemicals
- TollFree : +1 877 796-6397
- Tel : +1 832 582-8158
- Fax : +1 832 582-8590
Emergency telephone number
- Emergency phone #: +1 832 582-8158
2. HAZARDS IDENTIFICATION
2.1 Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
H302 Harmful if swallowed.
H410 Very toxic to aquatic life with long lasting effects.
2.2 GHS Label elements, including precautionary statements
Signal word: N/A
Hazard statement(s)
H302 Harmful if swallowed.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P330 Rinse mouth.
P391 Collect spillage.
P501 Dispose of contents/ container to an approved waste disposal plant.
2.3 Other hazards
None.
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1 Substances
Synonyms: D-threo -Pentitol, 1,5-anhydro-3-[[5-chloro-4-[4-fluoro-2-(1-hydroxy- 1-methylethyl)-1-(1-methylethyl)-1H -benzimidazol-6-yl]-2-pyrimi dinyl]amino]-2,3-dideoxy
Formula: C22H27ClFN5O3
Molecular Weight: 463.93
CAS No.: 2380321-51-5
4. FIRST AID MEASURES
4.1 Description of first aid measures
Eye contact
Remove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.
Skin contact
Rinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.
Inhalation
Immediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.
Ingestion
Wash out mouth with water; Do NOT induce vomiting; call a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2).
4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically.
5. FIRE FIGHTING MEASURES
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, dry chemical, foam, and carbon dioxide fire extinguisher.
5.2 Special hazards arising from the substance or mixture
During combustion, may emit irritant fumes.
5.3 Advice for firefighters
Wear self-contained breathing apparatus and protective clothing.
6. ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment and emergency procedures
Use full personal protective equipment. Avoid breathing powder, powder, powder or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Refer to protective measures listed in section 8.
6.2 Environmental precautions
Try to prevent further leakage or spillage. Keep the product away from drains or water courses.
6.3 Methods and materials for containment and cleaning up
Absorb powder with finely-powdered powder-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.
7. HANDLING AND STORAGE
7.1 Precautions for safe handling
Avoid inhalation, contact with eyes and skin. Avoid powder and powder formation. Use only in areas with appropriate exhaust ventilation.
7.2 Conditions for safe storage, including any incompatibilities
Keep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.
Store at -20°C(powder) or -80°C( in powder)
7.3 Specific end use(s)
N/A.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1 Control parameters
Components with workplace control parameters
This product contains no substances with occupational exposure limit values.
8.2 Exposure controls
Engineering controls
Ensure adequate ventilation. Provide accessible safety shower and eye wash station.
Personal protective equipment
Eye protection: Safety goggles with side-shields.
Hand protection: Protective gloves.
Skin and body protection: Impervious clothing.
Respiratory protection: Suitable respirator.
Environmental exposure controls: Keep the product away from drains, water courses or the soil. Clean spillages in a safe way as soon as possible.
9. PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties
Appearance: powder
Odor: N/A
Odor threshold: N/A
pH: N/A
Melting/freezing point: N/A
Boiling point/range: N/A
Flash point: N/A
Evaporation rate: N/A
Flammability (powder, gas): N/A
Upper/lower flammability or explosive limits: N/A
Vapor pressure: N/A
Vapor density: N/A
Relative density: N/A
Water solubility: mg/mL
Partition coefficient: N/A
Auto-ignition temperature: N/A
Decomposition temperature: N/A
Viscosity: N/A
Explosive properties: N/A
Oxidizing properties: N/A
9.2 Other safety information
N/A.
10. STABILITY AND REACTIVITY
10.1 Reactivity
N/A.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
N/A.
10.4 Conditions to avoid
N/A.
10.5 Incompatible materials
Strong acids/alkalis, strong oxidising/reducing agents.
10.6 Hazardous decomposition products
Under fire conditions, may decompose and emit toxic fumes.
Other decomposition products - no data available.
11. TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
Acute toxicity
Classified based on available data. For more details, see section 2.
Skin corrosion/irritation
Classified based on available data. For more details, see section 2.
Serious eye damage/irritation
Classified based on available data. For more details, see section 2.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2.
Germ cell mutagenicity
Classified based on available data. For more details, see section 2.
Carcinogenicity
IARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.
NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.
OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.
Reproductive toxicity
Classified based on available data. For more details, see section 2.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2.
Aspiration hazard
Classified based on available data. For more details, see section 2.
Additional information
RTECS No.: Unavailable
This information is based on our current knowledge. However the chemical, physical, and toxicological properties have not been completely investigated.
12. ECOLOGICAL INFORMATION
12.1 Toxicity
N/A.
12.2 Persistence and degradability
N/A.
12.3 Bioaccumulative potential
N/A.
12.4 Mobility in soil
N/A.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.
12.6 Other adverse effects
N/A.
13. DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
Product
Dispose substance in accordance with prevailing country, federal, state and local regulations.
Contaminated packaging
Conduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.
14. TRANSPORT INFORMATION
DOT (US)
This substance is considered to be non-hazardous for transport.
IMDG
UN number: 3077 Class: 9 Packing group: III EMS-No: F-A, S-F
Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, powder, N.O.S.
Marine pollutant: Marine pollutant
IATA
UN number: 3077 Class: 9 Packing group: III
Proper shipping name: Environmentally hazardous substance, powder, n.o.s.
15. REGULATORY INFORMATION
SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute Health Hazard.
Massachusetts Right To Know Components:
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components:
No components are subject to the Pennsylvania Right to Know Act.
New Jersey Right To Know Components:
No components are subject to the New Jersey Right to Know Act.
California Prop. 65 Components:
This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.
16. OTHER INFORMATION
Revision Date: 2026/07/14
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.