CAS No. 2230198-02-2
| IUPAC Name | 2-[[4-[6-[(4-cyano-2-fluorophenyl)methoxy]-2-pyridinyl]piperidin-1-yl]methyl]-3-[[(2S)-oxetan-2-yl]methyl]benzimidazole-5-carboxylic acid | |
|---|---|---|
| CAS Number | 2230198-02-2 | |
| Molecular Formula |
C31H30FN5O4 |
|
| Molecular Weight (MW) | 555.60 | |
| SMILES | OC(=O)C1=CC=C2N=C(CN3CCC(CC3)C4=NC(=CC=C4)OCC5=C(F)C=C(C=C5)C#N)[N](CC6CCO6)C2=C1 | |
| InChIKey | HYBAKUMPISVZQP-DEOSSOPVSA-N |
Danuglipron (PF-06882961) is a potent, non-peptide small-molecule agonist targeting the glucagon-like peptide-1 receptor (GLP-1R). Selective activation of GLP-1R by danuglipron stimulates canonical G protein-coupled signaling pathways, driving intracellular cyclic adenosine monophosphate (cAMP) accumulation. This signaling cascade leads to enhanced glucose-stimulated insulin secretion, regulation of glucagon release, and modulation of downstream cellular metabolic pathways essential for glucose homeostasis.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 100 mg/mL |
| DMSO |
10 mg/mL
(17.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| DMSO |
100 mg/mL
(179.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Danuglipron (PF-06882961) Clinical Trials
- Danuglipron (PF-06882961) Solubility in DMSO
- Danuglipron (PF-06882961) Stock Solution
- Danuglipron (PF-06882961) Storage
- Danuglipron (PF-06882961) Stability
- Danuglipron (PF-06882961) Molecular Weight
- Danuglipron (PF-06882961) SMILES
- Danuglipron (PF-06882961) Chemical Structure (2D and 3D)
- Danuglipron (PF-06882961) SDS｜MSDS