Zimlovisertib (PF-06650833) Chemical Structure (2D and 3D)

2D Structure

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2D chemical structural formula diagram.

3D Structure

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This 3D model represents a theoretically simulated conformation and is for reference only.

Check the Zimlovisertib (PF-06650833) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name	1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide
CAS Number	1817626-54-2
Molecular Formula	C₁₈H₂₀FN₃O₄
Molecular Weight (MW)	361.37
SMILES	CCC1C(NC(=O)C1F)COC2=NC=CC3=CC(=C(C=C32)OC)C(=O)N
InChIKey	JKDGKIBAOAFRPJ-ZBINZKHDSA-N

Concentration Volume Mass

Batch:

All in vitro solubility values are batch-tested experimental data (non-literature values).

Solvent	Solubility & Note
DMSO	72 mg/mL (199.24 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol	3 mg/mL
Water	Insoluble
DMSO	72 mg/mL (199.24 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol	4 mg/mL
Water	Insoluble

FAQ

Q: Why does a DMSO stock precipitate in media/saline?

A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.

How to fix it?