CAS No. 1632250-50-0

Batch: Purity:99.95
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PF-06446846 hydrochloride Chemical Structure
Chemical Structure
Check the PF-06446846 hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(3-chloro-2-pyridinyl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide;hydrochloride
CAS Number 1632250-50-0
Molecular Formula

C₂₂H₂₁Cl₂N₇O
Molecular Weight (MW) 470.35
SMILES Cl.ClC1=C(N=CC=C1)N(C2CCCNC2)C(=O)C3=CC=C(C=C3)[N]4N=NC5=C4N=CC=C5
InChIKey AQSJYIVIWBIHOU-UNTBIKODSA-N

Ordering Information

Biological Activity

PF-06446846 hydrochloride is an orally active, selective small-molecule inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) translation with an IC50 of 0.3 µM in Huh7 cells. It engages the human 80S ribosome to stall translation around codon 34 of the nascent chain. This selective translational arrest blocks PCSK9 synthesis, thereby reducing circulating PCSK9 levels and lowering plasma total cholesterol in vivo. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 94 mg/mL (199.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 94 mg/mL
Ethanol 94 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.