CAS No. 1013101-36-4

Batch: Purity:99.96
Check CoA
PF-04691502 Chemical Structure
Chemical Structure
Check the PF-04691502 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-amino-8-[4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methylpyrido[2,3-d]pyrimidin-7-one
CAS Number 1013101-36-4
Molecular Formula

C22H27N5O4
Molecular Weight (MW) 425.48
SMILES CC1=C2C=C(C(=O)N(C2=NC(=N1)N)C3CCC(CC3)OCCO)C4=CN=C(C=C4)OC
InChIKey XDLYKKIQACFMJG-UHFFFAOYSA-N

Biological Activity

PF-04691502 is an ATP-competitive dual PI3K and mTOR inhibitor targeting PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, and mTOR. By blocking the PI3K/AKT/mTOR signaling pathway, it suppresses phosphorylation of downstream effectors including AKT, p70S6K, and 4EBP1. This inhibition induces G1 cell cycle arrest, promotes p27 Kip1 expression, and triggers apoptosis in cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 14 mg/mL (32.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Yuan J, et al. Mol Cancer Ther. 2011;10(11):2189-99.

Jump to

Note: Technical data last updated: Sep 1, 2026.