CAS No. 939791-38-5

Batch: Purity:99.32
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PF-562271 Besylate Chemical Structure
Chemical Structure
Check the PF-562271 Besylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name benzenesulfonic acid;N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]-2-pyridinyl]methanesulfonamide
CAS Number 939791-38-5
Molecular Formula

C21H20F3N7O3S.C6H6O3S
Molecular Weight (MW) 665.66
SMILES CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C.C1=CC=C(C=C1)S(=O)(=O)O
InChIKey LKLWTLXTOVZFAE-UHFFFAOYSA-N

Ordering Information

Biological Activity

PF-562271 Besylate is a potent, ATP-competitive inhibitor of FAK (IC50 1.5 nM) with approximately 10-fold lower potency for Pyk2. By blocking FAK auto-phosphorylation, it disrupts downstream signaling cascades including the PI3K/AKT and ERK pathways. This target inhibition impairs tumor cell migration, invasion, proliferation, and survival, while demonstrating antiangiogenic and broad antitumor activity in preclinical cancer models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
4-Methylpyridine 25 mg/mL
DMSO 0.4 mg/mL (0.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.