For research use only. Not for use in humans.

Petosemtamab (Anti-EGFR / LGR5)

Synonyms: MCLA 158 Cat.No.A2474 Purity:99%

Petosemtamab (Anti-EGFR/LGR5) is a highly potent bispecific antibody against EGFR (Kd 0.22 nM) and LGR5 (Kd 0.86 nM). It blocks the appearance of metastases and slows the growth of primary tumors in experimental cancer models. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC). MW: 145.5 KD.

Quality Control

Batch: A247401 Purity: 99% Protein concentration: 5.241mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Specificity

Name	Citation	GPR	Others
AZD1981	1	+++
NF-56-EJ40	0	+
ML401	0	+++
PH-064	0	++++
NE 52-QQ57	1	+	IL-1β,TNF-α,PGE2
NIBR189	0	++
JMS-17-2	2	++++
OC000459	0	++
Kisspeptin-10 (human)	0	✔
CLP-3094	0	✔	AR

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Petosemtamab (Anti-EGFR/LGR5) is a highly potent bispecific antibody against EGFR (Kd 0.22 nM) and LGR5 (Kd 0.86 nM). It blocks the appearance of metastases and slows the growth of primary tumors in experimental cancer models. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC). MW: 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2213450-26-9
Molecular Weight	145.5 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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