CAS No. 6724-53-4

Batch: Purity:99.95
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Perhexiline maleate Chemical Structure
Chemical Structure
Check the Perhexiline maleate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (Z)-but-2-enedioic acid;2-(2,2-dicyclohexylethyl)piperidine
CAS Number 6724-53-4
Molecular Formula

C23H39NO4
Molecular Weight (MW) 393.56
SMILES OC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
InChIKey JDZOTSLZMQDFLG-BTJKTKAUSA-N

Ordering Information

Biological Activity

Perhexiline maleate is a carnitine palmitoyltransferase inhibitor that targets rat heart CPT1 (IC50 77 μM), rat liver CPT1 (IC50 148 μM), and CPT2. By blocking CPT1 activity, perhexiline inhibits mitochondrial fatty acid oxidation and shifts cellular energy production toward glucose utilization. This metabolic reprogramming alters cellular respiration and downstream nutrient-sensing pathways, suppressing mitochondrial ATP generation and inducing cytotoxicity in target cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (198.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.