CAS No. 39809-25-1
| CAS Number | 39809-25-1 | |
|---|---|---|
| Molecular Formula |
C10H15N5O3 |
|
| Molecular Weight (MW) | 253.26 | |
| SMILES | C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N |
Penciclovir is a purine acyclic nucleoside analogue with potent antiviral activity targeting viral DNA polymerase. Upon selective monophosphorylation by viral thymidine kinase, penciclovir is converted into its active triphosphate derivative by host cellular kinases. Penciclovir triphosphate competitively inhibits viral DNA polymerase and incorporates into growing viral DNA strands, thereby terminating chain elongation and suppressing viral replication. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
34 mg/mL
(134.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 1 mg/mL |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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