Clinical Trials

Pemetrexed disodium hydrate is evaluated across numerous clinical trials primarily focusing on advanced solid tumors, including non-small cell lung cancer, malignant pleural mesothelioma, stomach neoplasms, and pancreatic ductal carcinoma. Spanning Phase 1 safety evaluations to Phase 3 efficacy trials and Phase 4 post-marketing assessments, these studies are sponsored by both academic medical centers and pharmaceutical developers. The trial portfolio encompasses various recruitment statuses, including actively recruiting, completed, and active non-recruiting protocols.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06096844 RECRUITING
Advanced Lung Non-Small Cell Carcinoma; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8
National Cancer Institute (NCI)
 2024-07-19 PHASE3
NCT04198766 RECRUITING
Solid Tumor; Non-Small Cell Lung Cancer; Head and Neck Cancer; Melanoma; Gastric Cancer; Renal Cell Carcinoma; Urothelial Carcinoma; Resectable Non-Small-Cell Lung Cancer
Inhibrx Biosciences, Inc
 2019-12-10 PHASE1; PHASE2
NCT07642024 RECRUITING
Non-small Cell Lung Cancer
Sichuan Baili Pharmaceutical Co., Ltd.
 2026-07-24 PHASE2; PHASE3
NCT06731907 RECRUITING
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC
 2025-03-30 PHASE2
NCT04165070 RECRUITING
Carcinoma, Non-Small-Cell Lung
Merck Sharp & Dohme LLC
 2019-12-19 PHASE1; PHASE2
NCT06788912 RECRUITING
Lung Neoplasm Malignant
Merck Sharp & Dohme LLC
 2025-03-20 PHASE2
NCT05789082 RECRUITING
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2023-06-20 PHASE1; PHASE2
NCT07063745 RECRUITING
Metastatic Non-small Cell Lung Cancer With MTAP Deletion
Bristol-Myers Squibb
 2026-01-02 PHASE2; PHASE3
NCT07507188 NOT_YET_RECRUITING
Non Small Cell Lung Cancer
Yonsei University
 2026-04-06 PHASE2
NCT06109402 NOT_YET_RECRUITING
Stage II-IIIB(N2) Non-small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
 2023-12-20 PHASE2
NCT07001618 RECRUITING
NSCLC (Advanced Non-small Cell Lung Cancer)
Gustave Roussy, Cancer Campus, Grand Paris
 2025-11-17 PHASE2
NCT07709585 NOT_YET_RECRUITING
Advanced Non-small Cell Lung Cancer (NSCLC); EGFR Exon 19 Deletion Mutation; EGFR Exon 21 Mutation; EGFR Exon 21 L858R Mutation
Guangzhou University of Traditional Chinese Medicine
 2026-07-05 PHASE2
NCT06561386 RECRUITING
Non-small Cell Lung Cancer
Bristol-Myers Squibb
 2024-10-07 PHASE3
NCT07775040 NOT_YET_RECRUITING
Non-Small Cell Lung Cancer
Sichuan Cancer Hospital and Research Institute
 2026-08-20 PHASE2
NCT05719558 RECRUITING
Advanced Solid Tumors
Astellas Pharma Global Development, Inc.
 2023-03-13 PHASE1
NCT05067283 RECRUITING
Advanced Solid Tumors
Merck Sharp & Dohme LLC
 2021-12-17 PHASE1
NCT06745882 RECRUITING
Non-small Cell Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute
 2025-06-13 PHASE2
NCT06607185 ACTIVE_NOT_RECRUITING
Pancreatic Ductal Adenocarcinoma; Non-small Cell Lung Cancer; Colorectal Cancer; Advanced Solid Tumor; Metastatic Solid Tumor
Eli Lilly and Company
 2024-10-21 PHASE1
NCT04665206 RECRUITING
Solid Tumor, Adult; Mesothelioma; NSCLC
Vivace Therapeutics, Inc
 2021-03-24 PHASE1; PHASE2
NCT05633667 ACTIVE_NOT_RECRUITING
Lung Cancer; Advanced or Metastatic Non-Small-Cell Lung Cancer; Resectable Non-Small-Cell Lung Cancer
Gilead Sciences
 2023-03-16 PHASE2
NCT03899155 RECRUITING
Cancer
Bristol-Myers Squibb
 2019-08-09 PHASE2
NCT05555732 ACTIVE_NOT_RECRUITING
Metastatic Non Small Cell Lung Cancer
Daiichi Sankyo
 2023-01-11 PHASE3
NCT06630416 RECRUITING
Metastatic Bladder Urothelial Carcinoma; Metastatic Malignant Solid Neoplasm; Stage IV Bladder Cancer AJCC v8; MTAP Deletion
Northwestern University
 2024-11-27 PHASE2
NCT06632327 ACTIVE_NOT_RECRUITING
Resectable Lung Non-Small Cell Carcinoma; Stage II Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8
Alliance for Clinical Trials in Oncology
 2024-12-11 PHASE3
NCT07514793 NOT_YET_RECRUITING
Mesothelioma
Fudan University
 2026-04 PHASE2
NCT07608731 NOT_YET_RECRUITING
Large B-cell Lymphoma; Central Nervous System Lymphoma
Allison Winter
 2026-10 PHASE1
NCT07098988 RECRUITING
Metastatic Non-Squamous Non-Small Cell Lung Cancer; Adult Solid Tumor
CatalYm GmbH
 2025-08-01 PHASE2
NCT07661173 NOT_YET_RECRUITING
Non Small Cell Lung Cancer
Anhui Provincial Cancer Hospital
 2026-06-06 PHASE2
NCT06996782 RECRUITING
Advanced or Metastatic Non-small Cell Lung Cancer
AstraZeneca
 2025-11-24 PHASE1; PHASE2
NCT06712316 RECRUITING
Non-small Cell Lung Cancer
BioNTech SE
 2025-01-07 PHASE2; PHASE3
NCT07100080 RECRUITING
Non-Small Cell Lung Cancer
Bristol-Myers Squibb
 2025-11-05 PHASE2; PHASE3
NCT07020221 RECRUITING
Pancreatic Ductal Adenocarcinoma; Non Small Cell Lung Cancer; Colorectal Cancer; Solid Tumor, Adult; G12D Mutated KRAS
Verastem, Inc.
 2025-06-24 PHASE1; PHASE2
NCT06793215 RECRUITING
Non-Small Cell Lung Cancer; KRAS G12C Lung Cancer
Hoffmann-La Roche
 2025-10-24 PHASE3
NCT06097728 ACTIVE_NOT_RECRUITING
Unresectable Pleural Mesothelioma
AstraZeneca
 2023-11-09 PHASE3
NCT07181499 RECRUITING
NSCLC; Adjuvant Drug Therapy; EGFR
Betta Pharmaceuticals Co., Ltd.
 2025-09 PHASE2
NCT01878617 ACTIVE_NOT_RECRUITING
Medulloblastoma
St. Jude Children's Research Hospital
 2013-06-23 PHASE2
NCT06057935 RECRUITING
Malignant Peritoneal Mesothelioma; Peritoneal Mesothelioma; Mesothelioma; Mesothelioma, Malignant; Malignant Mesothelioma
Memorial Sloan Kettering Cancer Center
 2023-09-21 PHASE2
NCT07020065 RECRUITING
Metastatic NSCLC - Non-Small Cell Lung Cancer
Swiss Cancer Institute
 2026-04-10 PHASE2
NCT07754123 NOT_YET_RECRUITING
Advanced or Metastatic NSCLC
Jiangsu Hansoh Pharmaceutical Co., Ltd.
 2026-09-17 PHASE3
NCT07420439 NOT_YET_RECRUITING
Non Small Cell Lung Cancer Metastatic; Interstitial Lung Disease (ILD)
Intergroupe Francophone de Cancerologie Thoracique
 2026-09-15 PHASE2
NCT06281964 ENROLLING_BY_INVITATION
Non-Small-Cell Lung Cancer
Avistone Biotechnology Co., Ltd.
 2023-12-01 PHASE3
NCT06459180 ACTIVE_NOT_RECRUITING
Cervical Cancer
Merck Sharp & Dohme LLC
 2024-07-24 PHASE3
NCT05502237 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
Gilead Sciences
 2022-10-12 PHASE3
NCT06268210 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
Yonsei University
 2022-02-07 PHASE2
NCT06861218 NOT_YET_RECRUITING
Leptomeningeal Metastases
Zhejiang Cancer Hospital
 2025-04 PHASE2
NCT07128303 RECRUITING
Advanced Solid Tumor
Gilead Sciences
 2025-08-28 PHASE1
NCT06093503 WITHDRAWN
Non-Small Cell Lung Cancer
AbbVie
 2024-05-31 PHASE3
NCT07383116 NOT_YET_RECRUITING
Non Squamous Non-small Cell Lung Cancer
Shanghai Huaota Biopharmaceutical Co., Ltd.
 2026-01-15 PHASE3
NCT06441045 NOT_YET_RECRUITING
Leptomeningeal Metastasis
Fujian Cancer Hospital
 2024-10-01 PHASE2
NCT06908993 RECRUITING
Advanced Non Small Cell Lung Cancer; MET Exon 14 Mutation
Intergroupe Francophone de Cancerologie Thoracique
 2025-12-09 PHASE3
NCT05681195 RECRUITING
Primary Central Nervous System Lymphoma; Secondary Central Nervous System Lymphoma; Relapsed Cancer; Refractory Cancer
Baptist Health South Florida
 2024-04-25 PHASE2
NCT05764928 NOT_YET_RECRUITING
Nonsquamous Nonsmall Cell Neoplasm of Lung
Rgene Corporation
 2026-12-01 PHASE1; PHASE2
NCT05791097 WITHDRAWN
Non-small Cell Lung Cancer (NSCLC)
Novartis Pharmaceuticals
 2023-07-28 PHASE3
NCT07178795 RECRUITING
Non-squamous Non-small Cell Lung Cancer
Sichuan Baili Pharmaceutical Co., Ltd.
 2025-09-29 PHASE3
NCT06956001 RECRUITING
EGFR; NSCLC (Advanced Non-small Cell Lung Cancer)
Allist Pharmaceuticals, Inc.
 2024-11-19 PHASE3
NCT04605770 RECRUITING
Sarcoma,Soft Tissue
Yonsei University
 2020-12-22 PHASE2
NCT06901817 RECRUITING
Leptomeningeal Metastasis
Shanghai Cancer Hospital, China
 2025-03-01 PHASE2
NCT07154368 NOT_YET_RECRUITING
Non Small Cell Lung Cancer
Guangzhou JOYO Pharma Co., Ltd
 2025-09-23 PHASE3
NCT06561685 RECRUITING
Metastatic Solid Tumor; Advanced Solid Tumor; Non-small Cell Lung Cancer; SMARCA4-Deficient Tumor
Eli Lilly and Company
 2024-09-19 PHASE1
NCT05335941 ACTIVE_NOT_RECRUITING
Urothelial Carcinoma; Metastatic Cancer
M.D. Anderson Cancer Center
 2023-06-13 PHASE2
NCT03233139 ACTIVE_NOT_RECRUITING
Advanced Malignancies
Regeneron Pharmaceuticals
 2017-06-21 PHASE1
NCT04837716 ACTIVE_NOT_RECRUITING
Metastatic Lung Non-Small Cell Carcinoma; Recurrent Lung Non-Small Cell Carcinoma; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
M.D. Anderson Cancer Center
 2021-03-18 PHASE1
NCT04253964 RECRUITING
Nonsmall Cell Lung Cancer; Performance Status
Wake Forest University Health Sciences
 2020-07-01 PHASE2
NCT05487391 RECRUITING
Carcinoma, Non-Small-Cell Lung
Qilu Pharmaceutical Co., Ltd.
 2022-12-08 PHASE3
NCT06784791 RECRUITING
Lung Cancer (NSCLC)
University Hospital, Essen
 2024-11-06 PHASE2
NCT00715611 ACTIVE_NOT_RECRUITING
Mesothelioma
Memorial Sloan Kettering Cancer Center
 2008-10-11 PHASE2
NCT05198830 ACTIVE_NOT_RECRUITING
Lung Adenocarcinoma; Lung Large Cell Carcinoma; Lung Non-Squamous Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8
National Cancer Institute (NCI)
 2022-12-15 PHASE2
NCT05096663 ACTIVE_NOT_RECRUITING
Advanced Lung Non-Small Cell Carcinoma; Recurrent Lung Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
SWOG Cancer Research Network
 2022-03-15 PHASE2; PHASE3
NCT06564844 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
AstraZeneca
 2024-10-15 PHASE3
NCT06726265 ACTIVE_NOT_RECRUITING
Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
Immutep S.A.S.
 2025-03-21 PHASE3
NCT07070440 RECRUITING
Non Small Cell Lung Cancer
Dizal Pharmaceuticals
 2025-07-16 PHASE1; PHASE2
NCT06074588 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer (NSCLC)
Merck Sharp & Dohme LLC
 2023-11-12 PHASE3
NCT06969612 RECRUITING
NSCLC (Advanced Non-small Cell Lung Cancer)
Peking University Cancer Hospital & Institute
 2025-05-15 PHASE1
NCT04410796 RECRUITING
Metastatic Non-small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
 2020-05-28 PHASE2
NCT05715229 RECRUITING
Carcinoma, Non-Small-Cell Lung
Hackensack Meridian Health
 2023-09-29 PHASE2
NCT02817633 ACTIVE_NOT_RECRUITING
Neoplasms
Tesaro, Inc.
 2016-07-08 PHASE1
NCT05443126 RECRUITING
NSCLC
Ellipses Pharma
 2022-09-30 PHASE1; PHASE2
NCT06946797 ACTIVE_NOT_RECRUITING
Non-Small Cell Lung Cancer
Bristol-Myers Squibb
 2025-09-19 PHASE2
NCT06462092 RECRUITING
Leptomeningeal Metastases
Guangzhou Medical University
 2026-01-01 PHASE1; PHASE2
NCT02609776 ACTIVE_NOT_RECRUITING
Non-Small-Cell Lung Cancer
Janssen Research & Development, LLC
 2016-05-24 PHASE1
NCT07381829 RECRUITING
Advanced Solid Tumor Cancer
HC Biopharma Inc.
 2025-10-27 PHASE1
NCT06809530 ACTIVE_NOT_RECRUITING
Leptomeningeal Metastasis; Pemetrexed; PD-1 Inhibitor; CTLA4; Solid Tumors
Guangzhou Medical University
 2025-03-17 PHASE1; PHASE2
NCT06943820 RECRUITING
Non-small Cell Lung Cancer Stage IIIB/IV; Head and Neck Squamous Cell Carcinoma (HNSCC); Colorectal Adenocarcinoma; Advanced Solid Tumors
Akeso
 2025-05-21 PHASE1; PHASE2
NCT06652048 RECRUITING
Non-Small Cell Lung Cancer
Jialei Wang
 2024-10-01 PHASE2
NCT03786692 ACTIVE_NOT_RECRUITING
Non-Small Cell Carcinoma of Lung, TNM Stage 4
Fox Chase Cancer Center
 2019-09-04 PHASE2
NCT05456256 RECRUITING
Adenocarcinoma of Lung; Carcinoma, Non-Small-Cell Lung
Lantern Pharma Inc.
 2023-03-01 PHASE2
NCT07122687 RECRUITING
Resectable Stage IB-III Non-Squamous Non-Small Cell Lung Cancer
Innovent Biologics (Suzhou) Co. Ltd.
 2025-08-26 PHASE2
NCT04162015 ACTIVE_NOT_RECRUITING
Malignant Pleural Mesothelioma
Memorial Sloan Kettering Cancer Center
 2019-11-12 PHASE1
NCT06704620 NOT_YET_RECRUITING
Advanced and Metastatic NSCLC
Tianjin Medical University Cancer Institute and Hospital
 2024-12 PHASE3
NCT04129502 ACTIVE_NOT_RECRUITING
Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
Takeda
 2020-01-10 PHASE3
NCT06447662 ACTIVE_NOT_RECRUITING
Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung
Pfizer
 2024-06-27 PHASE1
NCT04991025 RECRUITING
Lung Cancer; Lung Cancer Stage II; Lung Cancer Stage III
Memorial Sloan Kettering Cancer Center
 2022-10-19 PHASE2
NCT05116462 ACTIVE_NOT_RECRUITING
Non-Small Cell Lung Cancer
Innovent Biologics (Suzhou) Co. Ltd.
 2024-03-15 PHASE3
NCT06762080 ACTIVE_NOT_RECRUITING
Leptomeningeal Metastasis
Guangzhou Medical University
 2025-03-07 PHASE1; PHASE2
NCT06687369 RECRUITING
Non Squamous Non Small Cell Lung Cancer
mAbxience Research S.L.
 2024-12-30 PHASE3
NCT06883630 ACTIVE_NOT_RECRUITING
Non-Small Cell Lung Cancer
RemeGen Co., Ltd.
 2025-03-13 PHASE1
NCT04339218 RECRUITING
Lung Adenocarcinoma; Cryotherapy Effect
Institut Bergonié
 2020-08-28 PHASE3
NCT06161441 ACTIVE_NOT_RECRUITING
Resectable Non-small Cell Lung Cancer
Regeneron Pharmaceuticals
 2024-07-16 PHASE2
NCT04966663 RECRUITING
Non Small Cell Lung Cancer; Complete Surgical Resection; Circulating Tumor DNA
University Health Network, Toronto
 2022-03-28 PHASE2
NCT06382116 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
Sichuan Baili Pharmaceutical Co., Ltd.
 2024-05-22 PHASE3
NCT04585490 RECRUITING
Non Small Cell Lung Cancer; NSCLC, Stage III; Nsclc
Maximilian Diehn
 2021-08-25 PHASE3
NCT06462222 ACTIVE_NOT_RECRUITING
Leptomeningeal Metastasis
Guangzhou Medical University
 2024-06-30 PHASE1; PHASE2
NCT06405230 TERMINATED
Lung Cancer, Non-Small Cell
GlaxoSmithKline
 2025-10-10 PHASE1; PHASE2
NCT06505837 ACTIVE_NOT_RECRUITING
Recurrent Metastatic Non-Squamous Non Small Cell Lung Cancer
Shanghai Junshi Bioscience Co., Ltd.
 2024-07-11 PHASE3
NCT06318286 ACTIVE_NOT_RECRUITING
Malignant Pleural Mesothelioma
Hyogo Medical University
 2024-03-13 PHASE2
NCT05298423 COMPLETED
Carcinoma, Non-Small-Cell Lung
Merck Sharp & Dohme LLC
 2022-05-03 PHASE3
NCT05048797 ACTIVE_NOT_RECRUITING
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
AstraZeneca
 2021-10-28 PHASE3
NCT04335292 RECRUITING
Non-Small Cell Lung Cancer
Mark Vincent
 2021-01-06 PHASE2
NCT05017012 COMPLETED
Advanced or Metastatic Solid Tumors
Merck Sharp & Dohme LLC
 2021-09-21 PHASE1
NCT06704724 TERMINATED
Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung
Pfizer
 2024-12-10 PHASE1
NCT07365410 NOT_YET_RECRUITING
Non-small Cell Lung Cancer (NSCLC); Brain Metastases; Furmonertinib; EGFR Mutation
Tianjin Medical University Cancer Institute and Hospital
 2026-01 PHASE2
NCT04638582 TERMINATED
Lung Cancer, Nonsmall Cell
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2022-08-28 PHASE2
NCT06688656 NOT_YET_RECRUITING
Lung Cancer
Shanghai Chest Hospital
 2025-03-31 PHASE2
NCT06812871 COMPLETED
Non-small Cell Lung Cancer Metastatic
Sun Yat-sen University
 2024-01-01 PHASE2
NCT05689671 ACTIVE_NOT_RECRUITING
Non-Small Cell Lung Cancer Metastatic
Nikolaj Frost MD
 2023-12-06 PHASE4
NCT06809517 RECRUITING
Leptomeningeal Metastasis; Intrathecal Drug Delivery
Guangzhou Medical University
 2025-03-18 PHASE1; PHASE2
NCT05117476 ACTIVE_NOT_RECRUITING
Advanced Solid Tumor; NSCLC
Cullinan Therapeutics Inc.
 2021-10-29 PHASE1
NCT04147351 COMPLETED
NSCLC Stage IIIB~IV
National Taiwan University Hospital
 2020-04-10 PHASE2
NCT05501665 RECRUITING
Lung Non-Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage III Lung Cancer
Vanderbilt-Ingram Cancer Center
 2023-05-09 PHASE1; PHASE2
NCT05668988 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
Dizal Pharmaceuticals
 2022-12-13 PHASE3
NCT06713057 NOT_YET_RECRUITING
Locally Advanced Thyroid Gland Carcinoma; Thyroid Cancer
West China Hospital
 2024-12-01 PHASE2
NCT03623776 WITHDRAWN
Efficacy and Safety
Sun Yat-sen University
 2019-02-01 PHASE2
NCT06659042 RECRUITING
Lung Cancer, Non-Small Cell
Shanghai Chest Hospital
 2024-11-20 PHASE2
NCT05136677 COMPLETED
Mesothelioma, Malignant
Bristol-Myers Squibb
 2022-01-25 PHASE2
NCT04695925 ACTIVE_NOT_RECRUITING
Non-small Cell Carcinoma; EGFR Gene Mutation
Li Zhang, MD
 2021-03-29 PHASE3
NCT05664971 COMPLETED
Advanced Lung Cancer
Shanghai Junshi Bioscience Co., Ltd.
 2023-02-09 PHASE1; PHASE2
NCT04649385 COMPLETED
Advanced Solid Tumor
BeiGene
 2021-03-04 PHASE1
NCT03520686 TERMINATED
Non Small Cell Lung Cancer
ImmunityBio, Inc.
 2018-05-18 PHASE3
NCT06455046 UNKNOWN
Cervical Cancer Recurrent
Fujian Cancer Hospital
 2023-10-11 PHASE2
NCT05754853 RECRUITING
Advanced or Metastatic Urothelium Cancer
Shanghai Miracogen Inc.
 2023-04-06 PHASE3
NCT03564691 COMPLETED
Neoplasms
Merck Sharp & Dohme LLC
 2018-07-11 PHASE1
NCT05430802 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
Tang-Du Hospital
 2022-02-24 PHASE2
NCT06537297 NOT_YET_RECRUITING
Non-small Cell Lung Cancer
Hunan Province Tumor Hospital
 2024-09-30 PHASE2
NCT04717375 TERMINATED
Cancer; Neoplasm
Sanofi
 2021-04-11 PHASE1; PHASE2
NCT05794477 UNKNOWN
Advanced Solid Tumor
Shanghai Hengrui Pharmaceutical Co., Ltd.
 2023-04-28 PHASE1; PHASE2
NCT05930665 UNKNOWN
Pleural Mesothelioma
Sun Yat-sen University
 2023-11-01 PHASE2
NCT05465733 UNKNOWN
Non-Small-Cell Lung
First Affiliated Hospital Xi'an Jiaotong University
 2022-08-01 PHASE2
NCT04530227 UNKNOWN
Early Stage Non-small Cell Lung Cancer
Tianjin Medical University Cancer Institute and Hospital
 2020-09-25 PHASE2
NCT03918278 COMPLETED
Neoplasms
Merck Sharp & Dohme LLC
 2019-06-19 PHASE1
NCT03944772 ACTIVE_NOT_RECRUITING
Non-Small Cell Lung Cancer
AstraZeneca
 2019-06-25 PHASE2
NCT05255302 RECRUITING
Metastatic NSCLC
Intergroupe Francophone de Cancerologie Thoracique
 2022-05-02 PHASE2; PHASE3
NCT03088540 COMPLETED
Carcinoma，Non-Small-Cell Lung; Lung Carcinomas, Non-Small-Cell; Non-small-cell Lung Carcinoma; Nonsmall Cell Lung Cancer
Regeneron Pharmaceuticals
 2017-05-29 PHASE3
NCT06396065 ACTIVE_NOT_RECRUITING
Non-Squamous Non-small Cell Lung Cancer
Summit Therapeutics
 2023-05-04 PHASE3
NCT06643000 RECRUITING
Non-small Cell Lung Cancer; Leptomeningeal Metastasis; EGFR Gene Mutation
Henan Cancer Hospital
 2024-12-20
NCT04832854 TERMINATED
Non-Small Cell Lung Cancer (NSCLC)
Hoffmann-La Roche
 2021-04-23 PHASE2
NCT03242915 COMPLETED
Non-small Cell Lung Cancer
University of Michigan Rogel Cancer Center
 2017-10-03 PHASE2
NCT04222972 TERMINATED
RET-fusion Non Small Cell Lung Cancer; Lung Neoplasm; Carcinoma, Non-Small-Cell Lung; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Disease; Carcinoma, Bronchogenic; Bronchial Diseases; Head and Neck Neoplasms; Adenocarcinoma; Carcinoma; Neoplasms by Histologic Type; Neoplasms, Germ Cell and Embryonal; Neoplasms, Nerve Tissue
Hoffmann-La Roche
 2020-07-24 PHASE3
NCT05810350 UNKNOWN
Non-small Cell Lung Cancer
Three Gorges Hospital of Chongqing University
 2023-01-01 PHASE2
NCT06110663 UNKNOWN
Non-Small Cell Lung Cancer
Jiangsu Hansoh Pharmaceutical Co., Ltd.
 2023-12-30 PHASE3
NCT03875144 SUSPENDED
Peritoneal Mesothelioma; Peritoneal Carcinomatosis
Institut du Cancer de Montpellier - Val d'Aurelle
 2020-09-10 PHASE2
NCT05577702 COMPLETED
Non Small Cell Lung Cancer
BeiGene
 2023-03-08 PHASE2
NCT04856176 TERMINATED
Advanced Lung Non-Small Cell Carcinoma; Non-Small Cell Carcinoma of Lung, TNM Stage 4
Tufts Medical Center
 2022-01-03 PHASE2
NCT03846310 COMPLETED
Non Small Cell Lung Cancer Metastatic; Non Small Cell Lung Cancer; Nonsquamous Nonsmall Cell Neoplasm of Lung; Sensitizing EGFR Gene Mutation
Arcus Biosciences, Inc.
 2019-04-01 PHASE1
NCT02794571 COMPLETED
Advanced/Metastatic Tumors
Genentech, Inc.
 2016-05-23 PHASE1
NCT04287894 TERMINATED
Stage III NSCLC
The Netherlands Cancer Institute
 2018-12-28 PHASE1
NCT01656551 UNKNOWN
Non-small Cell Lung Cancer Metastatic; Non-small Cell Lung Cancer Stage IIIB
National Cancer Institute, Naples
 2012-08 PHASE3
NCT04765059 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer
AstraZeneca
 2021-09-12 PHASE3
NCT05741021 UNKNOWN
Non-small Cell Lung Cancer; NSCLC; PD-1
Shandong New Time Pharmaceutical Co., LTD
 2023-03-01 PHASE2
NCT02784171 COMPLETED
Mesothelioma
Canadian Cancer Trials Group
 2016-11-11 PHASE2; PHASE3
NCT05911308 TERMINATED
Non-Small Cell Lung Cancer
UNC Lineberger Comprehensive Cancer Center
 2024-04-01 PHASE1
NCT05756972 ACTIVE_NOT_RECRUITING
NSCLC
Biotheus Inc.
 2023-06-26 PHASE2
NCT06020989 UNKNOWN
Non Small Cell Lung Cancer
Yonsei University
 2023-09 PHASE2
NCT05299125 COMPLETED
Metastatic Non-small Cell Lung Cancers
Latin American Cooperative Oncology Group
 2023-05-24 PHASE2
NCT05746481 TERMINATED
Non-small Cell Lung Cancer
Liza Villaruz, MD
 2023-08-10 PHASE2
NCT06094296 TERMINATED
NSCLC
Bristol-Myers Squibb
 2023-11-27 PHASE2
NCT04047862 COMPLETED
Locally Advanced and Metastatic Solid Tumors
BeiGene
 2019-08-15 PHASE1
NCT04367311 ACTIVE_NOT_RECRUITING
Lung Cancer; NSCLC
Nasser Hanna
 2020-05-22 PHASE2
NCT06315686 UNKNOWN
NSCLC
Jiangsu Province Nanjing Brain Hospital
 2022-09-29 PHASE2
NCT04970043 UNKNOWN
Lung Cancer Stage II
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
 2021-07-31
NCT02964013 COMPLETED
Neoplasms
Merck Sharp & Dohme LLC
 2016-12-13 PHASE1
NCT05132985 NOT_YET_RECRUITING
NSCLC; EGF-R Positive Non-Small Cell Lung Cancer
Liaoning Cancer Hospital & Institute
 2022-01-01 PHASE2
NCT04967417 COMPLETED
Non-small Cell Lung Cancer
Samsung Medical Center
 2022-05-26 PHASE2
NCT04619797 COMPLETED
Non-small Cell Lung Cancer (NSCLC)
Hoffmann-La Roche
 2020-12-15 PHASE2; PHASE3
NCT05298176 COMPLETED
Non-Small Cell Lung Cancer
Amsterdam UMC, location VUmc
 2022-01-04 PHASE2
NCT04524689 TERMINATED
Non-squamous Non-small-cell Lung Cancer (NSQ NSCLC)
Sanofi
 2020-10-26 PHASE2
NCT05104788 RECRUITING
Non-Small Cell Lung Cancer
Peking University Cancer Hospital & Institute
 2021-10-25 PHASE2
NCT06378892 Recruiting
Non Small Cell Lung Cancer Metastatic|ALK Gene Mutation
Centro di Riferimento Oncologico - Aviano
 2024-03-15 Phase 2
NCT05611879 UNKNOWN
NSCLC, Stage III
Beijing Tsinghua Chang Gung Hospital
 2023-03-12 PHASE2
NCT05267366 UNKNOWN
PFS; OS
Qingdao Central Hospital
 2022-02-01 PHASE2
NCT04683965 UNKNOWN
Colorectal Neoplasms
The First Affiliated Hospital with Nanjing Medical University
 2021-01-01 PHASE2
NCT03380468 UNKNOWN
Lung Neoplasms
Fudan University
 2018-01-01 PHASE2; PHASE3
NCT06010277 UNKNOWN
NSCLC; Mesothelioma; Thymoma
Amphia Hospital
 2023-02-06 PHASE4
NCT05386888 COMPLETED
NSCLC, Stage III
Genfleet Therapeutics (Shanghai) Inc.
 2022-09-09 PHASE2
NCT04786964 TERMINATED
Metastatic Non-squamous Non Small Cell Lung Cancer
Checkpoint Therapeutics, Inc.
 2021-12-08 PHASE3
NCT03137771 ACTIVE_NOT_RECRUITING
Recurrent Non-Small Cell Lung Carcinoma; Stage IV Non-Small Cell Lung Cancer
NRG Oncology
 2017-04-07 PHASE2
NCT04205812 COMPLETED
Metastatic Squamous Non-Small Cell Lung Cancer; Metastatic Nonsquamous Non-Small Cell Lung Cancer
Incyte Corporation
 2020-09-11 PHASE3
NCT05394233 UNKNOWN
Non-squamous Non-small Cell Lung Cancer; EGFR Gene Mutation
Sichuan Cancer Hospital and Research Institute
 2022-06-01 PHASE2
NCT05346952 UNKNOWN
Advanced Non-squamous Non-small Cell Lung Cancer
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
 2022-01-25 PHASE3
NCT01951482 COMPLETED
Non Squamous Non-small Cell Lung Cancer; Brain Metastases; Bevacizumab
Sun Yat-sen University
 2016-01 PHASE3
NCT04956146 UNKNOWN
Carcinoma, Non-Small-Cell Lung
The First Affiliated Hospital with Nanjing Medical University
 2022-02-02 PHASE2
NCT05011487 RECRUITING
Non-Small Cell Lung Cancer
Sun Yat-sen University
 2021-08-13 PHASE2
NCT04379635 ACTIVE_NOT_RECRUITING
Non Small Cell Lung Cancer
BeiGene
 2020-05-29 PHASE3
NCT03829319 COMPLETED
Nonsquamous Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC
 2019-03-25 PHASE3
NCT04697628 COMPLETED
Cervical Cancer
Seagen, a wholly owned subsidiary of Pfizer
 2021-02-22 PHASE3
NCT05459441 UNKNOWN
Glioma; Brain Metastases
Shanghai Pudong Hospital
 2022-01-01 EARLY_PHASE1
NCT03866980 TERMINATED
Lung Cancer Non-small Cell Stage IV
Akeso
 2018-11-27 PHASE3
NCT04964960 TERMINATED
Lung Cancer; Lung Cancer Metastatic; Brain Cancer; Cancer
John L. Villano, MD, PhD
 2022-05-19 PHASE2
NCT03319537 TERMINATED
Mesothelioma
Memorial Sloan Kettering Cancer Center
 2017-10-05 PHASE1; PHASE2
NCT04846452 UNKNOWN
Metastatic NSCLC; Recurrent NSCLC; Advanced Non-Small Cell Squamous Lung Cancer
The First Affiliated Hospital with Nanjing Medical University
 2021-06-01 PHASE2
NCT04194944 ACTIVE_NOT_RECRUITING
Non-Small Cell Lung Cancer
Eli Lilly and Company
 2020-02-17 PHASE3
NCT04396457 UNKNOWN
Non-squamous Non-small-cell Lung Cancer; Cancer, Lung
National Hospital Organization Nagoya Medical Center
 2020-05-25 PHASE2
NCT04107103 COMPLETED
SCCHN
AHS Cancer Control Alberta
 2020-03-19 PHASE2
NCT04956692 ACTIVE_NOT_RECRUITING
Non-Small Cell Lung Cancer
Merck Sharp & Dohme LLC
 2021-08-05 PHASE3
NCT04083066 UNKNOWN
Primary Central Nervous System Lymphoma
Mingzhi Zhang
 2019-09-05 PHASE4
NCT05215951 TERMINATED
Lung Cancer
AstraZeneca
 2022-01-19 PHASE2
NCT04846634 NOT_YET_RECRUITING
Resectable Locally Advanced Non-small Cell Lung Cancer
Tianjin Medical University Cancer Institute and Hospital
 2021-08 PHASE2
NCT03840902 TERMINATED
Non-small Cell Lung Cancer
EMD Serono Research & Development Institute, Inc.
 2019-04-16 PHASE2
NCT04194203 COMPLETED
Carcinoma, Non-Small-Cell Lung
Hoffmann-La Roche
 2020-04-09 PHASE3
NCT06010277 Recruiting
NSCLC|Mesothelioma|Thymoma
Amphia Hospital|Albert Schweitzer Hospital
 2023-02-06 Phase 4
NCT02120807 COMPLETED
Stage IV Lung Adenocarcinoma
Memorial Sloan Kettering Cancer Center
 2014-04-15 PHASE1
NCT03515837 COMPLETED
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC
 2018-06-29 PHASE3
NCT02535312 ACTIVE_NOT_RECRUITING
Advanced Malignant Solid Neoplasm; Advanced Peritoneal Malignant Mesothelioma; Advanced Pleural Malignant Mesothelioma; Recurrent Peritoneal Malignant Mesothelioma; Recurrent Pleural Malignant Mesothelioma; Refractory Malignant Solid Neoplasm; Unresectable Solid Neoplasm
National Cancer Institute (NCI)
 2016-03-08 PHASE1; PHASE2
NCT03574402 UNKNOWN
Carcinoma, Non-Small-Cell Lung
Guangdong Association of Clinical Trials
 2018-07-09 PHASE2
NCT03003962 ACTIVE_NOT_RECRUITING
Non Small Cell Lung Carcinoma NSCLC
AstraZeneca
 2017-01-02 PHASE3
NCT03228537 ACTIVE_NOT_RECRUITING
Biphasic Mesothelioma; Epithelioid Mesothelioma; Stage I Pleural Diffuse Malignant Mesothelioma AJCC v7; Stage IA Pleural Diffuse Malignant Mesothelioma AJCC v7; Stage IB Pleural Diffuse Malignant Mesothelioma AJCC v7; Stage II Pleural Diffuse Malignant Mesothelioma AJCC v7; Stage III Pleural Diffuse Malignant Mesothelioma AJCC v7
National Cancer Institute (NCI)
 2018-07-16 PHASE1
NCT04500717 UNKNOWN
Non Small Cell Lung Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
 2020-10 PHASE3
NCT04422392 TERMINATED
Non Small Cell Lung Cancer
Shanghai Pulmonary Hospital, Shanghai, China
 2020-07-13 PHASE2
NCT02709512 COMPLETED
Mesothelioma
Polaris Group
 2017-08-01 PHASE2; PHASE3
NCT03513666 COMPLETED
NSCLC
Shanghai Junshi Bioscience Co., Ltd.
 2018-04-09 PHASE2
NCT04022876 TERMINATED
Non Small Cell Lung Cancer; Small-cell Lung Cancer
Aileron Therapeutics, Inc.
 2019-09-03 PHASE1
NCT04861948 TERMINATED
Solid Tumors; Lung Adenocarcinoma; Osteosarcoma
Innovent Biologics (Suzhou) Co. Ltd.
 2021-05-25 PHASE1
NCT03838848 TERMINATED
Stage IV Non-small Cell Lung Cancer
Jiangsu Alphamab Biopharmaceuticals Co., Ltd
 2019-05-05 PHASE2
NCT03023319 COMPLETED
Carcinoma, Non-Small-Cell Lung; Mesothelioma; Bladder Cancer; Ovarian Cancer; Peritoneal Cancer; Thymoma; Thymus Cancer; Uterine Cervical Cancer
Nagla Abdel Karim
 2019-12-10 PHASE1
NCT04372927 TERMINATED
Locally Advanced Lung Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8
University of Washington
 2021-12-10 PHASE2
NCT04405674 UNKNOWN
Non Small Cell Lung Cancer
Shanghai Chest Hospital
 2020-07-15 PHASE2
NCT04203485 UNKNOWN
PD-L1 Positive Non-small Cell Lung Cancer
Jiangsu HengRui Medicine Co., Ltd.
 2020-06-15 PHASE3
NCT03526900 COMPLETED
Non-small Cell Lung Cancer Stage IV
Spanish Lung Cancer Group
 2018-07-07 PHASE2
NCT04971187 TERMINATED
Locally Advanced Lung Non-Squamous Non-Small Cell Carcinoma; Metastatic Lung Non-Squamous Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8; Unresectable Lung Non-Squamous Non-Small Cell Carcinoma
M.D. Anderson Cancer Center
 2021-06-30 PHASE2
NCT02864251 COMPLETED
Non-Small-Cell Lung Carcinoma
Bristol-Myers Squibb
 2017-03-17 PHASE3
NCT04706949 UNKNOWN
Lung Cancer, Non-small Cell
Fudan University
 2020-12-07 PHASE2
NCT03863483 UNKNOWN
Nonsquamous Non-Small Cell Lung Cancer
Xin-Hua Xu
 2019-03-26 PHASE2
NCT04470076 UNKNOWN
Non Small Cell Lung Cancer; Surgery; EGFR Activating Mutation; Chemotherapy; EGFR TKI
Fifth Affiliated Hospital, Sun Yat-Sen University
 2020-07-10 PHASE2
NCT03713944 TERMINATED
NSCLC Stage IV; NSCLC, Recurrent
Nasser Hanna
 2018-11-15 PHASE2
NCT02977169 UNKNOWN
Non-small Cell Lung Cancer Stage IIIA; Radiotherapy
Shanghai Chest Hospital
 2016-11 PHASE2
NCT04265534 TERMINATED
Non-Small Cell Lung Cancer; Non-squamous Non-small-cell Lung Cancer; Non-Squamous Non-Small Cell Neoplasm of Lung; KEAP1 Gene Mutation; NRF2 Gene Mutation; NFE2L2 Gene Mutation
Calithera Biosciences, Inc
 2020-07-24 PHASE2
NCT03843853 WITHDRAWN
Colorectal Neoplasms
The First Affiliated Hospital with Nanjing Medical University
 2019-05-01 PHASE2
NCT04042558 COMPLETED
NSCLC Stage IIIB; NSCLC Stage IV; EGFR Gene Mutation; ALK Gene Rearrangement Positive; ROS1 Gene Mutation
Centre Francois Baclesse
 2019-09-26 PHASE2
NCT04943627 WITHDRAWN
Advanced Cancer; Metastatic Cervical Cancer
Agenus Inc.
 2021-08-02 PHASE3
NCT02743923 UNKNOWN
Carcinoma, Non-Small Cell Lung
The Netherlands Cancer Institute
 2016-04 PHASE3
NCT03809637 COMPLETED
Sarcoma
Yonsei University
 2017-01-10 PHASE2
NCT04470674 WITHDRAWN
Lung Cancer; Non-small Cell Lung Cancer; PD-L1 Gene Mutation; KRAS Activating Mutation
Shirish M Gadgeel
 2021-04-06 PHASE2
NCT03987867 UNKNOWN
Non-small Cell Lung Cancer; First-line Treatment
Tianjin Medical University Cancer Institute and Hospital
 2019-06-01 PHASE1
NCT04439890 UNKNOWN
Advanced Non-squamous Cell Non-small Cell Lung Cancer
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
 2019-08-08 PHASE3
NCT03655821 TERMINATED
Non Small Cell Lung Cancer; Mesothelioma
Radboud University Medical Center
 2019-02-01 PHASE4
NCT03177291 COMPLETED
Lung Cancer; Non Small Cell Lung Cancer; Advanced Cancer; Metastatic Lung Cancer; Squamous Cell Lung Cancer; Non-Squamous Non-Small Cell Neoplasm of Lung
H. Lee Moffitt Cancer Center and Research Institute
 2017-09-26 PHASE1
NCT02439450 COMPLETED
Non-small Cell Lung Cancer
Heat Biologics
 2015-04-15 PHASE1; PHASE2
NCT02710396 TERMINATED
Carcinoma, Non-Small-Cell Lung
Columbia University
 2016-05-31 PHASE2
NCT03562871 COMPLETED
NSCLC
IO Biotech
 2018-08-22 PHASE1; PHASE2
NCT02654587 TERMINATED
Non Small Cell Lung Cancer
OSE Immunotherapeutics
 2016-02-12 PHASE3
NCT03775486 ACTIVE_NOT_RECRUITING
Non-small Cell Lung Cancer NSCLC
AstraZeneca
 2018-12-21 PHASE2
NCT03366766 TERMINATED
Non-Squamous Non-Small Cell Lung Carcinoma; Stage I Non-Small Cell Lung Cancer; Stage IA Non-Small Cell Lung Carcinoma; Stage IB Non-Small Cell Lung Carcinoma; Stage II Non-Small Cell Lung Cancer; Stage IIA Non-Small Cell Lung Carcinoma; Stage IIB Non-Small Cell Lung Carcinoma; Stage IIIA Non-Small Cell Lung Cancer
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
 2017-12-20 PHASE2
NCT02725918 UNKNOWN
Non-small Cell Lung Cancer
Guangdong Association of Clinical Trials
 2016-04-01 PHASE2
NCT02001168 UNKNOWN
Non-small Cell Lung Cancer
Xinjiang Medical University
 2013-10 PHASE3
NCT03062800 UNKNOWN
Advanced Nsclc
Qilu Hospital of Shandong University
 2016-12 PHASE2
NCT02862457 COMPLETED
Neoplasms; Carcinoma, Non-Small-Cell Lung
Merck Sharp & Dohme LLC
 2016-08-23 PHASE1
NCT02076477 UNKNOWN
Oligo-metastatic Stage IV Non-small Cell Lung Cancer
Sichuan Cancer Hospital and Research Institute
 2014-01 PHASE3
NCT03655834 COMPLETED
Non Small Cell Lung Cancer; Mesothelioma
Radboud University Medical Center
 2019-02-01 PHASE4
NCT02899299 COMPLETED
Mesothelioma
Bristol-Myers Squibb
 2016-11-29 PHASE3
NCT02535325 COMPLETED
Locally Advanced Lung Non-Squamous Non-Small Cell Carcinoma; Stage III Lung Adenocarcinoma AJCC v7; Stage III Lung Large Cell Carcinoma AJCC v7; Stage III Lung Non-Small Cell Cancer AJCC v7; Stage IIIA Lung Adenocarcinoma AJCC v7; Stage IIIA Lung Large Cell Carcinoma AJCC v7; Stage IIIA Lung Non-Small Cell Cancer AJCC v7; Stage IIIB Lung Adenocarcinoma AJCC v7; Stage IIIB Lung Large Cell Carcinoma AJCC v7; Stage IIIB Lung Non-Small Cell Cancer AJCC v7; Stage IV Lung Adenocarcinoma AJCC v7; Stage IV Lung Large Cell Carcinoma AJCC v7; Stage IV Lung Non-Small Cell Cancer AJCC v7
National Cancer Institute (NCI)
 2015-09-30 PHASE1
NCT03792503 WITHDRAWN
Advanced Non-squamous Non-small-cell Lung Cancer
Xinqiao Hospital of Chongqing
 2019-02 PHASE4
NCT03498222 WITHDRAWN
Carcinoma, Non-Small-Cell Lung
Queen Mary University of London
 2018-06-01 PHASE1
NCT03663205 COMPLETED
Non-Small Cell Lung Cancer
BeiGene
 2018-07-23 PHASE3
NCT03647956 UNKNOWN
NSCLC Stage IIIB; NSCLC Stage IV; EGFR Activating Mutation
The University of Hong Kong
 2018-10-01 PHASE2
NCT03628521 UNKNOWN
Lung Cancer; Advanced Stage
Shanghai Chest Hospital
 2018-07-20 PHASE1
NCT02693717 TERMINATED
Metastatic Urothelial Carcinoma
M.D. Anderson Cancer Center
 2017-05-09 PHASE2
NCT03058094 WITHDRAWN
NSCLC
Hangzhou ACEA Pharmaceutical Research Co., Ltd.
 2018-12 PHASE3
NCT02777788 UNKNOWN
Cancer
Shanghai University of Traditional Chinese Medicine
 2014-09 PHASE2; PHASE3
NCT03193788 UNKNOWN
Bladder Cancer; Ureter Cancer; Transitional Cell Carcinoma
Asan Medical Center
 2017-01 PHASE3
NCT02383212 COMPLETED
Advanced Cancer; Advanced Malignancies
Regeneron Pharmaceuticals
 2015-02-02 PHASE1
NCT03607539 COMPLETED
Lung Neoplasms
Innovent Biologics (Suzhou) Co. Ltd.
 2018-08-23 PHASE3
NCT02264990 COMPLETED
Non-squamous Non-small Cell Lung Cancer
AbbVie
 2014-09-30 PHASE3
NCT03269162 UNKNOWN
NSCLC
lihegen
 2016-09-30 PHASE3
NCT03351842 RECRUITING
Chemotherapy, Adjuvant; Lung Adenocarcinoma, Stage I; Treatment; Histological Type of Neoplasm
Shanghai Pulmonary Hospital, Shanghai, China
 2017-09-01 PHASE2
NCT02603003 COMPLETED
Non-small Cell Lung Cancer(NSCLC)
Shanghai University of Traditional Chinese Medicine
 2015-06 PHASE1
NCT03215706 COMPLETED
Non-Small Cell Lung Cancer
Bristol-Myers Squibb
 2017-08-24 PHASE3
NCT02657434 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2016-04-30 PHASE3
NCT02624700 TERMINATED
Breast Cancer; Metastatic Breast Cancer; Recurrent Breast Cancer
Virginia Commonwealth University
 2016-01-28 PHASE2
NCT03489616 UNKNOWN
Carcinoma, Non-Small-Cell Lung
Shandong Cancer Hospital and Institute
 2018-01-15
NCT02886195 UNKNOWN
EGFR Gene Mutation
Fujian Cancer Hospital
 2016-07 PHASE3
NCT03950674 COMPLETED
Non-Small-Cell Lung Carcinoma
Merck Sharp & Dohme LLC
 2016-02-22 PHASE3
NCT03256721 TERMINATED
Nonsmall Cell Lung Cancer
Fuzhou General Hospital
 2017-08-16 PHASE2
NCT02531854 WITHDRAWN
Carcinoma, Non-Small-Cell Lung
Advaxis, Inc.
 2018-12 PHASE2
NCT03432598 COMPLETED
Locally Advanced Lung Cancer; Metastatic Lung Cancer
BeiGene
 2017-08-24 PHASE2
NCT03085914 COMPLETED
Solid Tumor
Incyte Corporation
 2017-05-02 PHASE1; PHASE2
NCT03151161 UNKNOWN
Lung, Carcinoma
Sun Yat-sen University
 2015-12 PHASE2
NCT02117167 COMPLETED
Non-small Cell Lung Cancer Metastatic
UNICANCER
 2014-04-23 PHASE2
NCT03061058 UNKNOWN
Stomach Neoplasms; Chemotherapy Effect; Chemotherapeutic Toxicity
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
 2013-04-01 PHASE3
NCT02357147 TERMINATED
Mesothelioma, Malignant
Morphotek
 2015-11-03 PHASE2
NCT02453282 ACTIVE_NOT_RECRUITING
Non-Small-Cell Lung Carcinoma NSCLC
AstraZeneca
 2015-07-21 PHASE3
NCT03850444 COMPLETED
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC
 2016-08-01 PHASE3
NCT02220894 COMPLETED
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC
 2014-10-30 PHASE3
NCT02296671 WITHDRAWN
Esophagogastric Cancer
Washington University School of Medicine
 2015-02 PHASE2
NCT02029690 TERMINATED
Pleural Mesothelioma Malignant Advanced; Peritoneal Mesothelioma Malignant Advanced; Non-squamous Non-small Cell Lung Carcinoma; Uveal Melanoma; Hepatocellular Carcinoma; Glioma; Sarcomatoid Carcinoma
Polaris Group
 2014-04-23 PHASE1
NCT02723578 COMPLETED
Metastatic Colorectal Cancer
Yonsei University
 2015-12-01 PHASE2
NCT02274038 TERMINATED
Non-small Cell Lung Cancer; Starting Pemetrexed Based Therapy; Unresectable Cancer
University of Pennsylvania
 2015-03
NCT02079636 COMPLETED
Carcinoma, Non-small Cell Lung
Eli Lilly and Company
 2014-03-28 PHASE1
NCT02397928 COMPLETED
Malignant Pleural Mesothelioma
NovoCure Ltd.
 2015-02 PHASE2
NCT02322281 TERMINATED
Non-small Cell Lung Cancer
Clovis Oncology, Inc.
 2015-02 PHASE3
NCT01376310 TERMINATED
Cancer
Novartis Pharmaceuticals
 2010-11-02 PHASE2
NCT02980991 COMPLETED
Lung Adenocarcinoma
Fudan University
 2015-12 PHASE2
NCT02399566 UNKNOWN
Lung Adenocarcinoma
Hunan Province Tumor Hospital
 2015-05 PHASE4
NCT02804646 UNKNOWN
Adenocarcinoma of Lung
Anhui Provincial Hospital
 2016-06 PHASE4
NCT02578680 COMPLETED
Non-Small-Cell Lung Carcinoma
Merck Sharp & Dohme LLC
 2016-01-15 PHASE3
NCT02974933 UNKNOWN
Nonsmall Cell Lung Cancer
Wuling Ou
 2016-11 PHASE2
NCT01868022 COMPLETED
Neoplasms
GlaxoSmithKline
 2013-10-09 PHASE1
NCT01958372 COMPLETED
Adenocarcinoma of the Lung; Adenosquamous Cell Lung Cancer; Bronchoalveolar Cell Lung Cancer; Large Cell Lung Cancer; Recurrent Non-small Cell Lung Cancer; Squamous Cell Lung Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer
Barbara Ann Karmanos Cancer Institute
 2014-08 PHASE1
NCT02868892 TERMINATED
Adenocarcinoma of the Cervix; Adenosquamous Cell Carcinoma of the Cervix
Western Regional Medical Center
 2015-07 PHASE2
NCT02259582 COMPLETED
Nonsquamous Nonsmall Cell Neoplasm of Lung
OncoMed Pharmaceuticals, Inc.
 2015-02 PHASE2
NCT02607423 WITHDRAWN
Stage IIIA Non-Small Cell Lung Cancer
ECOG-ACRIN Cancer Research Group
 2015-11-19 PHASE2
NCT01041781 TERMINATED
Lung Cancer
Alliance for Clinical Trials in Oncology
 2010-02 PHASE3
NCT02669719 UNKNOWN
Non Small Cell Lung Cancer
Shanghai Chest Hospital
 2016-01 PHASE2
NCT02900742 COMPLETED
Cancer
Shanghai University of Traditional Chinese Medicine
 2013-03 PHASE3
NCT02013453 WITHDRAWN
Cancer of Head and Neck
University of Michigan Rogel Cancer Center
 2013-12 PHASE2
NCT02039674 COMPLETED
Non-small Cell Lung Carcinoma
Merck Sharp & Dohme LLC
 2014-02-21 PHASE1; PHASE2
NCT00741221 COMPLETED
Non-small-cell Lung Cancer
Hellenic Oncology Research Group
 2008-06 PHASE2
NCT02284490 UNKNOWN
Brain Metastases
Rongjie Tao
 2014-11 PHASE2
NCT01723800 COMPLETED
Recurrent Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
City of Hope Medical Center
 2013-07 PHASE1
NCT01719536 COMPLETED
NSCLC
Betta Pharmaceuticals Co., Ltd.
 2012-12 PHASE3
NCT01189968 COMPLETED
Non Small Cell Lung Cancer
OncoMed Pharmaceuticals, Inc.
 2010-09 PHASE1
NCT00614822 COMPLETED
Non Small Cell Lung Cancer
Christiana Care Health Services
 2007-11 PHASE2
NCT00390000 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
Mayo Clinic
 2007-01-25 PHASE1
NCT01395758 COMPLETED
Metastatic Non-Small Cell Lung Cancer
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
 2011-07 PHASE2
NCT01828099 COMPLETED
Non-Small Cell Lung Cancer
Novartis Pharmaceuticals
 2013-07-09 PHASE3
NCT02276560 TERMINATED
Stage IIIA Non-Small Cell Lung Cancer
UNC Lineberger Comprehensive Cancer Center
 2015-01 PHASE2
NCT01063283 COMPLETED
Advanced Non-squamous Non-Small Cell Lung Cancer
University of Chicago
 2010-03
NCT01774578 TERMINATED
Non-small Cell Lung Cancer; Progression of Non-small Cell Lung Cancer; Non-small Cell Lung Cancer Recurrent
NewLink Genetics Corporation
 2013-02 PHASE2; PHASE3
NCT02093962 TERMINATED
Non-small Cell Lung Cancer
ImmunoGenesis
 2014-06 PHASE2
NCT01496742 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Genentech, Inc.
 2012-04 PHASE2
NCT00324805 COMPLETED
Stage IB Lung Non-Small Cell Carcinoma AJCC v7; Stage IIA Lung Non-Small Cell Carcinoma AJCC v7; Stage IIB Lung Non-Small Cell Carcinoma AJCC v7; Stage IIIA Lung Non-Small Cell Cancer AJCC v7
National Cancer Institute (NCI)
 2007-07-19 PHASE3
NCT00996567 COMPLETED
Cancer
University Hospital, Ghent
 2009-10 PHASE2
NCT02083679 TERMINATED
Carcinoma, Non-Small-Cell Lung
EMD Serono
 2014-07 PHASE1
NCT00906282 COMPLETED
Non Small Cell Lung Cancer
SCRI Development Innovations, LLC
 2009-06 PHASE2
NCT01443078 COMPLETED
Lung Cancer
Memorial Sloan Kettering Cancer Center
 2011-10 PHASE2
NCT01836341 WITHDRAWN
Non-small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
 2013-04 PHASE1
NCT01928160 WITHDRAWN
Recurrent Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
Vanderbilt-Ingram Cancer Center
 2014-06 PHASE2
NCT02148380 COMPLETED
Non-Small-Cell Lung Cancer
Baohui Han
 2014-05
NCT01204307 COMPLETED
Advanced Non-Squamous Non-Small Cell Lung Cancer
Chang Gung Memorial Hospital
 2010-01 PHASE2
NCT01593293 UNKNOWN
Non-small Cell Lung Cancer
Asan Medical Center
 2012-03 PHASE3
NCT01397305 COMPLETED
Rectal Cancer
Isofol Medical AB
 2011-04-14 PHASE1; PHASE2
NCT00470548 TERMINATED
Breast Cancer; Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific
University of California, Davis
 2007-04 PHASE1; PHASE2
NCT01700400 COMPLETED
Non Small Cell Lung Cancer
Cancer Research and Biostatistics Clinical Trials Consortium
 2012-09 PHASE1
NCT00703976 COMPLETED
Cancer
University of Pittsburgh
 2008-10 PHASE2
NCT01860040 TERMINATED
Non-squamous Cell Non-Metastatic Non-Small Cell Lung Cancer; Squamous Cell Non-Metastatic Non-Small Cell Lung Cancer
Western Regional Medical Center
 2013-04 PHASE2
NCT01502202 UNKNOWN
Non Small Cell Lung Cancer; Adenocarcinoma
National Cancer Center, Korea
 2012-03 PHASE2
NCT01116219 COMPLETED
Lung Cancer
Swiss Cancer Institute
 2010-06 PHASE2
NCT01172028 COMPLETED
Breast Cancer; Esophageal Cancer; Gastric Cancer; Head and Neck Cancer; Lung Cancer; Ovarian Cancer; Prostate Cancer
University of Arizona
 2005-09 PHASE1
NCT01783834 COMPLETED
Previous Treated Metastatic Non-small Cell Lung Cancer
Gachon University Gil Medical Center
 2008-02 PHASE2
NCT01544179 COMPLETED
Non-Small Cell Lung Cancer
AstraZeneca
 2012-03-15 PHASE3
NCT00754364 TERMINATED
NSCLC
Armando Santoro, MD
 2008-10 PHASE2
NCT00807573 COMPLETED
Lung Cancer
Memorial Sloan Kettering Cancer Center
 2008-12 PHASE2
NCT00334594 COMPLETED
Malignant Mesothelioma
Swiss Cancer Institute
 2005-11-14 PHASE2
NCT01860508 UNKNOWN
Non-small Cell Lung Cancer
Fudan University
 2013-02
NCT01769066 COMPLETED
NSCLC
Fudan University
 2009-12 PHASE2; PHASE3
NCT01102231 COMPLETED
Stage III Non-small Cell Lung Cancer
Intergroupe Francophone de Cancerologie Thoracique
 2010-03 PHASE2
NCT01490437 COMPLETED
Urothelial Carcinoma
Asan Medical Center
 2008-07 PHASE2
NCT01209520 COMPLETED
Lung Cancer; Non Small Cell Lung Carcinoma; Hypermethylation
University of Miami
 2009-07
NCT01447225 COMPLETED
Solid Tumors
Merrimack Pharmaceuticals
 2011-10 PHASE1
NCT01192165 COMPLETED
Cancer
GlaxoSmithKline
 2010-09-14 PHASE1
NCT01473563 COMPLETED
Nonsquamous Non-Small Cell Neoplasm of Lung; Non-Small Cell Lung Cancer Metastatic; Non-Small Cell Lung Cancer Stage IIIB
Eli Lilly and Company
 2011-12 PHASE2
NCT01087970 COMPLETED
Head and Neck Neoplasms
Eli Lilly and Company
 2010-08 PHASE2
NCT00942825 COMPLETED
Metastatic Non-squamous Non Small Cell Lung Cancer
CanBas Co. Ltd.
 2009-04 PHASE2
NCT00743379 COMPLETED
Non-Small Cell Lung Cancer; Prostate Cancer; Pancreatic Cancer
Threshold Pharmaceuticals
 2008-08 PHASE1; PHASE2
NCT00940069 COMPLETED
Non-small-cell Lung Cancer; Adenocarcinoma
Hunan Province Tumor Hospital
 2009-03 PHASE2
NCT01579630 UNKNOWN
NSCLC
Taipei Veterans General Hospital, Taiwan
 2011-03 PHASE2; PHASE3
NCT00923273 TERMINATED
Carcinoma, Non-Small-Cell Lung
National Cancer Institute (NCI)
 2008-02-29 PHASE1; PHASE2
NCT00438204 TERMINATED
Lung Cancer
Barbara Ann Karmanos Cancer Institute
 2006-05 PHASE2
NCT00948675 COMPLETED
Advanced Non-Small Cell Lung Cancer
Eli Lilly and Company
 2009-09-01 PHASE3
NCT00921310 TERMINATED
Carcinoma, Non-Small-Cell Lung
Washington University School of Medicine
 2009-09 PHASE1; PHASE2
NCT00769600 TERMINATED
Recurrent Non Small Cell Lung Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2008-11 PHASE2
NCT01088620 SUSPENDED
Carcinoma, Non-Small-Cell Lung
WiSP Wissenschaftlicher Service Pharma GmbH
 2010-04 PHASE2
NCT01126736 COMPLETED
Non Small Cell Lung Cancer
Eisai Inc.
 2010-06-10 PHASE1; PHASE2
NCT01531790 COMPLETED
Non-Small Cell Lung Cancer
Jiangsu Simcere Pharmaceutical Co., Ltd.
 2011-09 PHASE1
NCT01211275 COMPLETED
Malignant Pleural Mesothelioma
The Netherlands Cancer Institute
 2009-05-22 PHASE1; PHASE2
NCT01004250 COMPLETED
Non-Small Cell Lung Cancer
Eli Lilly and Company
 2009-10 PHASE2
NCT01005680 COMPLETED
Non Small Cell Lung Cancer
Eli Lilly and Company
 2009-11 PHASE3
NCT00895648 TERMINATED
Mesothelioma; Pleural Mesothelioma
University Health Network, Toronto
 2009-01 PHASE2
NCT00301808 COMPLETED
Lung Cancer
Barbara Ann Karmanos Cancer Institute
 2005-11 PHASE2
NCT01185847 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2010-11 PHASE2
NCT01313663 TERMINATED
Lung Cancer, Small Cell
GlaxoSmithKline
 2011-02 PHASE2
NCT01187615 TERMINATED
Small Cell Lung Carcinoma
Bayer
 2010-08 PHASE1
NCT01143974 COMPLETED
Locally Advanced Malignant Neoplasm
Chinese Academy of Medical Sciences
 2010-06 PHASE4
NCT00556322 COMPLETED
Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2006-03 PHASE3
NCT01565538 COMPLETED
Lung Cancer
Si-Yu Wang
 2008-12 PHASE2
NCT00762034 COMPLETED
Non-small Cell Lung Cancer
Eli Lilly and Company
 2008-12 PHASE3
NCT00702299 COMPLETED
Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer
University of Arizona
 2007-09 PHASE1
NCT00550173 COMPLETED
Non-Small-Cell Lung Cancer
Eli Lilly and Company
 2007-11 PHASE2
NCT00545948 TERMINATED
Carcinoma, Non-Small-Cell Lung
Duke University
 2007-12 PHASE2
NCT00577707 COMPLETED
Non Small Cell Lung Cancer; Lung Cancer
Memorial Sloan Kettering Cancer Center
 2007-11 PHASE2
NCT01192230 UNKNOWN
Carcinoma, Non-Small-Cell Lung
Fudan University
 2009-06 PHASE2
NCT00482014 COMPLETED
Non-Small-Cell Lung Cancer
Eli Lilly and Company
 2007-05 PHASE1; PHASE2
NCT00507858 COMPLETED
Head and Neck Cancer
M.D. Anderson Cancer Center
 2005-09 PHASE1
NCT01109615 TERMINATED
Metastatic Colorectal Cancer
Vejle Hospital
 2010-04 PHASE2
NCT00265785 TERMINATED
Lung Cancer
SWOG Cancer Research Network
 2006-07 PHASE2
NCT00749346 COMPLETED
Non-small Cell Lung Cancer; NSCLC
NovoCure Ltd.
 2008-05 PHASE1; PHASE2
NCT00794417 TERMINATED
Advanced Carcinoma; Non-small Cell Lung Cancer
Regeneron Pharmaceuticals
 2008-11-30 PHASE1; PHASE2
NCT00806819 COMPLETED
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim
 2008-12 PHASE3
NCT00961415 COMPLETED
Non-Squamous Non-Small Cell Lung Cancer
Hoffmann-La Roche
 2009-08 PHASE3
NCT01105390 WITHDRAWN
Advanced Malignant Mesothelioma; Epithelial Mesothelioma; Recurrent Malignant Mesothelioma; Sarcomatous Mesothelioma
National Cancer Institute (NCI)
 2010-04 PHASE2
NCT00248495 COMPLETED
Lung Cancer
Roswell Park Cancer Institute
 2005-06-08 PHASE2
NCT00517595 COMPLETED
Non-Small Cell Lung Cancer
Accelerated Community Oncology Research Network
 2007-08 PHASE2
NCT00768755 COMPLETED
Carcinoma, Non-Small Cell Lung
Pfizer
 2009-01 PHASE1; PHASE2
NCT00871403 COMPLETED
Lung Cancer, Non-Small Cell
GlaxoSmithKline
 2009-07 PHASE2
NCT00799240 COMPLETED
Non Small Cell Lung Cancer
University of Kansas
 2009-06 PHASE2
NCT00606021 COMPLETED
Non Small Cell Lung Cancer
Eli Lilly and Company
 2008-01 PHASE2
NCT00434174 COMPLETED
Non Small Cell Lung Cancer
Novartis Pharmaceuticals
 2006-12 PHASE1
NCT01194453 COMPLETED
Non-small Cell Lung Cancer; Efficacy
Sun Yat-sen University
 2009-11 PHASE2
NCT00589667 COMPLETED
Head and Neck Cancer
Memorial Sloan Kettering Cancer Center
 2006-09 PHASE2
NCT00520676 COMPLETED
Non-Small Cell Lung Cancer
Eli Lilly and Company
 2007-10 PHASE3
NCT00789373 COMPLETED
Non-Small Cell Lung Cancer
Eli Lilly and Company
 2008-11 PHASE3
NCT00295503 COMPLETED
Mesothelioma
University of Texas Southwestern Medical Center
 2006-02 PHASE2
NCT02182102 COMPLETED
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim
 2005-09 PHASE1
NCT00903292 UNKNOWN
Non-Small Cell Lung Cancer
National Cheng-Kung University Hospital
 2009-03
NCT00528619 COMPLETED
Neoplasms
Pfizer
 2006-11 PHASE1
NCT00440414 COMPLETED
Non Small Cell Lung Cancer
Hellenic Oncology Research Group
 2006-04 PHASE3
NCT00415194 COMPLETED
Head and Neck Neoplasms
Eli Lilly and Company
 2006-12 PHASE3
NCT00227539 COMPLETED
Lung Cancer
University of Washington
 2005-07 PHASE2
NCT00415636 COMPLETED
Cancer
Eli Lilly and Company
 2007-01 PHASE1
NCT00614965 COMPLETED
Non Small Cell Lung Cancer
Hellenic Oncology Research Group
 2006-11 PHASE2
NCT00456261 COMPLETED
Lung Cancer
SCRI Development Innovations, LLC
 2007-03 PHASE2
NCT00520936 COMPLETED
Osteosarcoma; Medulloblastoma; Sarcoma, Ewing's; Neuroblastoma (Measurable Disease); Neuroblastoma (Metaiodobenzylguanidine; Positive Evaluable); Rhabdomyosarcoma; Ependymoma; Non-brainstem High-grade Glioma
Eli Lilly and Company
 2007-09 PHASE2
NCT00489359 COMPLETED
Ovarian Cancer; Primary Peritoneal Cancer
Eli Lilly and Company
 2005-07 PHASE1; PHASE2
NCT00712062 WITHDRAWN
Primary Central Nervous System Lymphoma
University of Florida
 2009-02 PHASE2
NCT00424242 COMPLETED
Brain and Central Nervous System Tumors; Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Lymphoproliferative Disorder; Metastatic Cancer; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Precancerous Condition; Secondary Myelofibrosis; Unspecified Adult Solid Tumor, Protocol Specific
Northwestern University
 2007-01 EARLY_PHASE1
NCT00745875 COMPLETED
Non Small Cell Lung Cancer; Lung Cancer
AstraZeneca
 2008-08 PHASE2
NCT00732992 COMPLETED
Neoplasm, Malignant
Pfizer
 2008-08 PHASE1
NCT00487669 COMPLETED
Advanced Non-small Cell Lung Cancer
Dartmouth-Hitchcock Medical Center
 2006-10 PHASE2
NCT00383266 TERMINATED
Esophageal Neoplasms
Washington University School of Medicine
 2006-10 PHASE2
NCT00101283 COMPLETED
Mesothelioma
Eastern Cooperative Oncology Group
 2006-02-23 PHASE2
NCT01442909 COMPLETED
Non-small-cell Lung Cancer
Taipei Veterans General Hospital, Taiwan
 2008-03 PHASE4
NCT00308750 COMPLETED
Non-Small Cell Lung Cancer
Eli Lilly and Company
 2006-03 PHASE2
NCT00528281 COMPLETED
Lung Cancer, Non-Small Cell
GlaxoSmithKline
 2007-09-20 PHASE1
NCT00733031 TERMINATED
Cancer,; Solid Tumors; Advanced Solid Malignancies
AstraZeneca
 2008-08 PHASE1
NCT00533429 COMPLETED
Non-small Cell Lung Cancer
Eli Lilly and Company
 2007-10 PHASE2
NCT00427466 COMPLETED
Sarcoma
University Hospital Tuebingen
 2007-01 PHASE2
NCT00226577 COMPLETED
Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute
 2004-02 PHASE2
NCT00350792 COMPLETED
Non Small Cell Lung Cancer
Eli Lilly and Company
 2006-08 PHASE2
NCT00320073 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
UNC Lineberger Comprehensive Cancer Center
 2006-08 PHASE1
NCT00530621 COMPLETED
Non-small Cell Lung Cancer
Eli Lilly and Company
 2007-09 PHASE2
NCT01004601 COMPLETED
Non Small Cell Lung Cancer
Chang Gung Memorial Hospital
 2005-03
NCT00380718 COMPLETED
Non-small Cell Lung Cancer
Eli Lilly and Company
 2006-11 PHASE4
NCT00351039 TERMINATED
Non-Small Cell Lung Cancer
H. Lee Moffitt Cancer Center and Research Institute
 2006-07 PHASE1; PHASE2
NCT00370292 COMPLETED
Non Small Cell Lung Cancer
Eli Lilly and Company
 2006-09 PHASE2
NCT00473486 TERMINATED
Carcinoma, Non-Small-Cell Lung
University Hospital Muenster
 2007-05 PHASE1; PHASE2
NCT00394147 TERMINATED
Head and Neck Cancer
Fox Chase Cancer Center
 2006-10 PHASE2
NCT00191308 COMPLETED
Non-Small Cell Lung Cancer; Carcinoma
Eli Lilly and Company
 2005-05 PHASE2
NCT00330915 COMPLETED
Rectal Neoplasms
Eli Lilly and Company
 2006-06 PHASE2
NCT00315861 COMPLETED
Ovarian Cancer; Endometrial Cancer; Cervical Cancer; Lung Cancer
SCRI Development Innovations, LLC
 2006-03 PHASE1
NCT00293579 COMPLETED
Head and Neck Cancer
Ohio State University Comprehensive Cancer Center
 2006-02 PHASE2
NCT00190671 COMPLETED
Breast Cancer
Eli Lilly and Company
 2005-06 PHASE1; PHASE2
NCT00149214 COMPLETED
Breast Cancer
Eli Lilly and Company
 2005-09 PHASE2
NCT00321308 TERMINATED
Carcinoma, Non-Small Cell Lung
Pfizer
 2006-09 PHASE2
NCT00063570 COMPLETED
Breast Cancer; Breast Neoplasms
Eli Lilly and Company
 2003-07 PHASE2
NCT00268437 TERMINATED
Esophageal Cancer
Alliance for Clinical Trials in Oncology
 2006-04 PHASE2
NCT00383331 TERMINATED
Non-Small-Cell Lung Cancer
Eli Lilly and Company
 2007-02 PHASE2
NCT00259285 TERMINATED
Non-Small-Cell Lung Cancer
Eli Lilly and Company
 2005-11 PHASE2
NCT00106626 COMPLETED
Advanced Cancer
Merck Sharp & Dohme LLC
 2005-08 PHASE1
NCT00106002 COMPLETED
Breast Cancer; Breast Neoplasms, Male; Carcinoma, Ductal
Eli Lilly and Company
 2005-04 PHASE2
NCT00502567 COMPLETED
Advanced Solid Tumor
AstraZeneca
 2005-01 PHASE1
NCT00190983 COMPLETED
Cervical Intraepithelial Neoplasia; Uterine Neoplasms; Genital Neoplasms, Female
Eli Lilly and Company
 2005-02 PHASE2
NCT00387322 COMPLETED
Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific
University of California, Davis
 2005-03 PHASE1; PHASE2
NCT00377520 COMPLETED
Neoplasms; Neoplasms by Site; Urogenital Neoplasms; Genital Neoplasms, Female; Uterine Neoplasms; Endometrial Neoplasms; Cancer of Endometrium; Endometrial Cancer; Cancer of the Endometrium; Endometrium Cancer; Neoplasms, Endometrial
Eli Lilly and Company
 2006-09 PHASE2
NCT00096187 TERMINATED
Gestational Trophoblastic Tumor
Gynecologic Oncology Group
 2005-07 PHASE2
NCT00230542 COMPLETED
Ovarian Cancer; Peritoneal Cancer; Fallopian Tube Cancer
Dana-Farber Cancer Institute
 2005-09 PHASE2
NCT01172470 COMPLETED
Head and Neck Cancer
University of Chicago
 2005-06 PHASE2
NCT00470405 COMPLETED
Lymphoma; Solid Tumor
Vanderbilt-Ingram Cancer Center
 2004-05 PHASE1
NCT00107419 COMPLETED
Sarcoma
SWOG Cancer Research Network
 2005-09 PHASE2
NCT00087711 COMPLETED
Non Small Cell Lung Carcinoma
Eli Lilly and Company
 2004-07 PHASE3
NCT00389805 COMPLETED
Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific
University of California, Davis
 2005-03 PHASE1; PHASE2
NCT00087087 COMPLETED
Ovarian Cancer; Primary Peritoneal Cavity Cancer
Gynecologic Oncology Group
 2004-07 PHASE2
NCT00198133 COMPLETED
Thymoma; Thymic Carcinoma
Patrick Joseph Loehrer Sr.
 2005-01 PHASE2
NCT00078260 COMPLETED
Non-Small Cell Lung Cancer
Eli Lilly and Company
 2003-12 PHASE3
NCT00087113 COMPLETED
Cervical Cancer
Gynecologic Oncology Group
 2004-08 PHASE2
NCT00506051 COMPLETED
Carcinoma; Non-Small Cell Lung; Lung Cancer
Genzyme, a Sanofi Company
 2005-07 PHASE1
NCT00070473 COMPLETED
Unspecified Childhood Solid Tumor, Protocol Specific
Children's Oncology Group
 2003-10 PHASE1
NCT00216216 TERMINATED
Small Cell Lung Cancer
Hoosier Cancer Research Network
 2005-01 PHASE2
NCT00022646 COMPLETED
Lung Cancer
Alliance for Clinical Trials in Oncology
 2001-08 PHASE2
NCT00290017 TERMINATED
Carcinoma, Non-Small-Cell Lung; Lung Cancer; Neoplasms, Lung; Neoplasms, Pulmonary
Point Therapeutics
 2006-02 PHASE3
NCT00034502 COMPLETED
Colorectal Cancer
Eli Lilly and Company
 PHASE1; PHASE2
NCT00034619 COMPLETED
Colorectal Cancer
Eli Lilly and Company
 PHASE2
NCT00192088 COMPLETED
Advanced Gastric Carcinoma
Eli Lilly and Company
 2004-05 PHASE2
NCT00191750 COMPLETED
Carcinoma, Small Cell
Eli Lilly and Company
 2004-07 PHASE2
NCT00061477 COMPLETED
Mesothelioma
Eli Lilly and Company
 2002-12 PHASE2
NCT00191412 COMPLETED
Liver Cancer
Eli Lilly and Company
 2005-01 PHASE2
NCT00061451 COMPLETED
Carcinoma, Non-Small-Cell Lung
Eli Lilly and Company
 2002-12 PHASE2
NCT00095225 COMPLETED
Non-Small-Cell Lung Carcinoma; Neoplasm Recurrence, Local
Genentech, Inc.
 2004-07 PHASE2
NCT00055432 TERMINATED
Ovarian Cancer; Peritoneal Cancer
Eli Lilly and Company
 PHASE2
NCT00989690 UNKNOWN
Lung Cancer
Istituto Scientifico H. San Raffaele
 2008-02 PHASE3
NCT00191347 COMPLETED
Breast Cancer
Eli Lilly and Company
 2004-10 PHASE2
NCT00744900 COMPLETED
Lung Cancer
University Hospital, Brest
 2008-09 PHASE2
NCT00386815 COMPLETED
Malignant Pleural Mesothelioma
Eli Lilly and Company
 2006-10 PHASE2
NCT00079872 COMPLETED
Colorectal Cancer
Eli Lilly and Company
 2004-02 PHASE2
NCT00034606 COMPLETED
Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Neoplasms
Eli Lilly and Company
 PHASE2
NCT00035061 COMPLETED
Urologic Neoplasms; Metastases, Neoplasm
Eli Lilly and Company
 PHASE2
NCT00190840 COMPLETED
Carcinoma, Non-Small Cell Lung
Eli Lilly and Company
 2003-09 PHASE2
NCT00061464 COMPLETED
Carcinoma, Non-Small-Cell Lung
Eli Lilly and Company
 2003-02 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-09-04)

Check the Pemetrexed Disodium Hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Pemetrexed disodium hydrate functions as a multi-targeted antifolate that inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase with Ki values of 1.3 nM, 7.2 nM, and 65 nM, respectively, thereby blocking essential nucleotide biosynthesis pathways. This inhibition of purine and pyrimidine synthesis triggers cellular autophagy and apoptosis, which suppresses tumor cell proliferation and provides the mechanistic basis for its clinical application in non-small cell lung cancer and malignant pleural mesothelioma.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.