CAS No. 149676-40-4

Batch: Purity:99.96
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Pefloxacin Mesylate Dihydrate Chemical Structure
Chemical Structure
Check the Pefloxacin Mesylate Dihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;methanesulfonic acid;dihydrate
CAS Number 149676-40-4
Molecular Formula

C17H20FN3O3.CH4O3S.2H2O
Molecular Weight (MW) 465.49
SMILES CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O.CS(=O)(=O)O.O.O
InChIKey LEULAXMUNMRLPW-UHFFFAOYSA-N

Ordering Information

Biological Activity

Pefloxacin Mesylate Dihydrate is a broad-spectrum third-generation fluoroquinolone antibacterial agent that targets bacterial topoisomerase II (DNA gyrase) and topoisomerase IV. By inhibiting these essential enzymes, it disrupts DNA replication, transcription, and repair processes in bacterial cells. This inhibition leads to accumulation of double-stranded DNA breaks, ultimately causing bacterial cell death and exhibiting potent bactericidal activity against a wide range of Gram-positive and Gram-negative pathogens.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 67 mg/mL
DMSO 9 mg/mL (19.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.