CAS No. 1382979-44-3
Batch:
Purity:99.02
Chemical Structure
Check the
Paxalisib (GDC-0084)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(6,6-dimethyl-4-morpholin-4-yl-8,9-dihydropurino[8,9-c][1,4]oxazin-2-yl)pyrimidin-2-amine | |
|---|---|---|
| CAS Number | 1382979-44-3 | |
| Molecular Formula |
C18H22N8O2 |
|
| Molecular Weight (MW) | 382.42 | |
| SMILES | CC1(C2=NC3=C(N2CCO1)N=C(N=C3N4CCOCC4)C5=CN=C(N=C5)N)C | |
| InChIKey | LGWACEZVCMBSKW-UHFFFAOYSA-N |
Paxalisib (GDC-0084) is a brain-penetrant inhibitor of PI3K and mTOR, exhibiting Kiapp values offor PI3Kα,for PI3Kβ,for PI3Kδ,for PI3Kγ, andfor mTOR. It inhibits the PI3K/AKT/mTOR signaling pathway to suppress downstream cellular proliferation and survival, demonstrating potent antiproliferative activity across preclinical glioblastoma models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(13.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
3 mg/mL
(7.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
10 mg/mL
(26.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
8 mg/mL
(20.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
10 mg/mL
(26.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Paxalisib (GDC-0084) Clinical Trials
- Paxalisib (GDC-0084) Solubility in DMSO
- Paxalisib (GDC-0084) Stock Solution
- Paxalisib (GDC-0084) Storage
- Paxalisib (GDC-0084) Stability
- Paxalisib (GDC-0084) Molecular Weight
- Paxalisib (GDC-0084) SMILES
- Paxalisib (GDC-0084) Chemical Structure (2D and 3D)
- Paxalisib (GDC-0084) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.