CAS No. 217797-14-3

Batch: Purity:98
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Paroxetine mesylate Chemical Structure
Chemical Structure
Check the Paroxetine mesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;methanesulfonic acid
CAS Number 217797-14-3
Molecular Formula

C19H20FNO3.CH4O3S
Molecular Weight (MW) 425.47
SMILES CS(=O)(=O)O.C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4
InChIKey SHIJTGJXUHTGGZ-RVXRQPKJSA-N

Ordering Information

Biological Activity

Paroxetine mesylate is a phenylpiperidine derivative and selective serotonin reuptake inhibitor (SSRI) targeting the serotonin transporter. By blocking neuronal reuptake of serotonin at the presynaptic membrane, it enhances serotonergic neurotransmission within the central nervous system. This elevation in synaptic serotonin levels modulates downstream signaling to mediate characteristic antidepressant and anxiolytic behavioral phenotypes. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 85 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 10 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.