CAS No. 19666-76-3

Batch: Purity:99.39
Check CoA
Panaxadiol Chemical Structure
Chemical Structure
Check the Panaxadiol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol
CAS Number 19666-76-3
Molecular Formula

C30H52O3
Molecular Weight (MW) 460.73
SMILES CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CCC5C4(CCC(C5(C)C)O)C)C)O)C)C
InChIKey PVLHOJXLNBFHDX-XHJPDDKBSA-N

Biological Activity

Panaxadiol is a natural triterpene sapogenin that functions as a calcium channel inhibitor with potent anticancer, cardioprotective, and anti-arrhythmic activities. By blocking calcium currents, it decreases channel open time and open state probability, thereby reducing intracellular calcium influx. This modulation attenuates cardiac arrhythmias and suppresses downstream cell proliferation and survival pathways in cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 22 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Cancer Letters. 2004;214(2):IFC.

Jump to

Note: Technical data last updated: Sep 1, 2026.