CAS No. 135729-61-2
Batch:
Purity:99
Chemical Structure
Check the
Palonosetron
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 135729-61-2 | |
|---|---|---|
| Molecular Formula |
C19H24N2O |
|
| Molecular Weight (MW) | 296.41 | |
| SMILES | C1CC2CN(C(=O)C3=CC=CC(=C23)C1)C4CN5CCC4CC5 |
Palonosetron is a selective 5-HT3 receptor antagonist with a Ki value of. By binding with high affinity to 5-HT3 receptors, it potently inhibits serotonin-induced ion channel activation and subsequent cellular depolarization. This targeted blockade disrupts downstream calcium influx and serotonergic signaling pathways in peripheral and central neurons, leading to suppressed emetic reflex responses. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(199.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.