CAS No. 3486-67-7
Batch:
Purity:98.26
Chemical Structure
Check the
Palmatine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium | |
|---|---|---|
| CAS Number | 3486-67-7 | |
| Molecular Formula |
C21H22NO4 |
|
| Molecular Weight (MW) | 352.4 | |
| SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC | |
| InChIKey | QUCQEUCGKKTEBI-UHFFFAOYSA-N |
Palmatine is a natural isoquinoline alkaloid with diverse pharmacological activities, including antidepressant, antioxidative, and anticancer properties. It inhibits cancer cell proliferation and migration by suppressing oncogenic signaling pathways, such as AKT/mTOR and NF-kB, which promotes cell cycle arrest and induces apoptosis. Additionally, palmatine exhibits anti-inflammatory and mucosal-protective effects by downregulating pro-inflammatory cytokine expression. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(198.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 20 mg/mL |
| Ethanol | 20 mg/mL |
| DMSO |
70 mg/mL
(198.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 20 mg/mL |
| Ethanol | 12 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.