CAS No. 286936-40-1
Batch:
Purity:99.09
Chemical Structure
Check the
OTX008
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[2-(dimethylamino)ethyl]-2-[[26,27,28-tris[2-[2-(dimethylamino)ethylamino]-2-oxoethoxy]-25-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3(28),4,6,9(27),10,12,15,17,19(26),21,23-dodecaenyl]oxy]acetamide | |
|---|---|---|
| CAS Number | 286936-40-1 | |
| Molecular Formula |
C52H72N8O8 |
|
| Molecular Weight (MW) | 937.18 | |
| SMILES | CN(C)CCNC(=O)COC1=C2CC3=CC=CC(=C3OCC(=O)NCCN(C)C)CC4=CC=CC(=C4OCC(=O)NCCN(C)C)CC5=CC=CC(=C5OCC(=O)NCCN(C)C)CC1=CC=C2 | |
| InChIKey | CQVAQQNDZCZBSU-UHFFFAOYSA-N |
Biological Activity
OTX008 is a calixarene derivative that acts as a selective inhibitor of galectin-1 (Gal1). By targeting Gal1, it suppresses downstream MAPK/ERK and AKT/mTOR signaling pathways, which in turn inhibits endothelial cell proliferation, migration, and tumor angiogenesis. Furthermore, OTX008 demonstrates significant anti-tumor activity by inducing cell cycle arrest and apoptosis in various tumor models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 25 mg/mL |
| DMSO |
3 mg/mL
(3.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | 25 mg/mL |
| DMSO |
6 mg/mL
(6.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | 25 mg/mL |
| DMSO |
5 mg/mL
(5.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.