CAS No. 1800487-55-1
Batch:
Purity:99.96
Chemical Structure
Check the
OT-82
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[2-(4-fluorophenyl)ethynyl]-N-[3-(1H-pyrazol-4-yl)propyl]-4-pyridin-4-ylbenzamide | |
|---|---|---|
| CAS Number | 1800487-55-1 | |
| Molecular Formula |
C26H21FN4O |
|
| Molecular Weight (MW) | 424.47 | |
| SMILES | FC1=CC=C(C=C1)C#CC2=CC(=CC=C2C3=CC=NC=C3)C(=O)NCCCC4=C[NH]N=C4 | |
| InChIKey | CEPAXRIKSUXHHB-UHFFFAOYSA-N |
OT-82 is a novel, potent, and orally active nicotinamide phosphoribosyltransferase (NAMPT) inhibitor that displays selective toxicity toward cells of hematopoietic origin. Inhibition of NAMPT, the key rate-limiting enzyme in NAD+ biosynthesis, results in intracellular NAD+ depletion, suppression of energy metabolism, and subsequent induction of apoptotic cell death in targeted cancer cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 85 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.