AZD9291 (Osimertinib) is a potent, selective, irreversible ATP-competitive mutant EGFR inhibitor. It affects MAPK/ERK and PI3K/AKT signaling by covalently binding to the Cys797 residue to block autophosphorylation, effectively inhibiting tumor cell proliferation and inducing apoptosis.
AZD9291 (Osimertinib) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for AZD9291 (Osimertinib) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.