CAS No. 1421373-65-0

Batch: Purity:99.99
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AZD9291 (Osimertinib) Chemical Structure
Chemical Structure
Check the AZD9291 (Osimertinib) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
CAS Number 1421373-65-0
Molecular Formula

C28 H33 N7 O2
Molecular Weight (MW) 499.61
SMILES CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
InChIKey DUYJMQONPNNFPI-UHFFFAOYSA-N

Ordering Information

Biological Activity

AZD9291 (Osimertinib) is an oral, irreversible, and mutant-selective EGFR inhibitor that potently targets sensitizing EGFR mutations, including exon 19 deletion and L858R/T790M resistance mutants, while sparing wild-type EGFR. By selectively inhibiting EGFR phosphorylation, AZD9291 disrupts downstream AKT/mTOR and MAPK signaling cascades. This pathway blockade inhibits proliferation and induces apoptosis in mutant EGFR-driven cancer cell models, effectively overcoming T790M-mediated TKI resistance. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 99 mg/mL (198.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 99 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.