Onvansertib (NMS-1286937, NMS-P937): Mechanism of Action

Onvansertib (NMS-1286937, NMS-P937) MOA:Targeting PLK1/Cell Cycle Pathway for Metastatic Colorectal Cancer

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Onvansertib is a potent and highly specific PLK1 inhibitor. It affects PI3K/AKT/mTOR, hypoxia, and DNA repair signaling pathways by inducing G2/M mitotic arrest and chromosomal abnormalities, thereby inhibiting cancer cell proliferation and promoting apoptosis.

Primary Applications and Mechanism of Action