CAS No. 1474034-05-3

Batch: Purity:99.91
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Omaveloxolone (RTA-408) Chemical Structure
Chemical Structure
Check the Omaveloxolone (RTA-408) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicen-4a-yl]-2,2-difluoropropanamide
CAS Number 1474034-05-3
Molecular Formula

C33H44F2N2O3
Molecular Weight (MW) 554.71
SMILES CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)NC(=O)C(C)(F)F)C
InChIKey RJCWBNBKOKFWNY-IDPLTSGASA-N

Ordering Information

Biological Activity

Omaveloxolone (RTA-408) is a synthetic triterpenoid that acts as an activator of the cytoprotective Nrf2 transcription factor and an inhibitor of NF-kB signaling. Activation of the Nrf2 pathway enhances the expression of downstream antioxidant genes, including NQO1 and HMOX1, while inhibition of NF-kB suppresses pro-inflammatory signaling, collectively mitigating oxidative stress and cellular damage.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (180.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.