CAS No. 919973-83-4
| IUPAC Name | 4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-methylbenzenesulfonamide | |
|---|---|---|
| CAS Number | 919973-83-4 | |
| Molecular Formula |
C17H18BrN3O4S |
|
| Molecular Weight (MW) | 440.31 | |
| SMILES | CC1=C(C=CC(=C1)Br)S(=O)(=O)NC2=CC3=C(C=C2OC)N(C(=O)N3C)C | |
| InChIKey | YUNQZQREIHWDQT-UHFFFAOYSA-N |
OF-1 is a potent small-molecule inhibitor targeting the BRPF1B and BRPF2 bromodomains. By selectively binding to BRPF family bromodomains, it disrupts the interaction with acetylated histone lysine residues and destabilizes histone acetyltransferase scaffolding complexes. Consequently, this target inhibition modulates chromatin accessibility, downregulates downstream oncogenic transcriptional pathways, and inhibits cellular proliferation in epigenetically deregulated cancer phenotypes. [1][2]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(172.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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