CAS No. 41443-28-1
Batch:
Purity:99.63
Chemical Structure
Check the
ODQ
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one | |
|---|---|---|
| CAS Number | 41443-28-1 | |
| Molecular Formula |
C9H5N3O2 |
|
| Molecular Weight (MW) | 187.15 | |
| SMILES | O=C1ON=C2C=NC3=C(C=CC=C3)N12 | |
| InChIKey | LZMHWZHOZLVYDL-UHFFFAOYSA-N |
ODQ is a potent and selective inhibitor of soluble guanylyl cyclase (sGC). By targeted inhibition of sGC activity, ODQ suppresses nitric oxide-stimulated cyclic GMP (cGMP) synthesis, blocking downstream NO/sGC/cGMP signaling pathways. This inhibition reduces intracellular cGMP levels and modulates vascular tone, platelet aggregation, and cellular responses. Additionally, ODQ enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
37 mg/mL
(197.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.