CAS No. 459789-99-2

Batch: Purity:99.72
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Obeticholic Acid (INT-747) Chemical Structure
Chemical Structure
Check the Obeticholic Acid (INT-747) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
CAS Number 459789-99-2
Molecular Formula

C26H44O4
Molecular Weight (MW) 420.63
SMILES CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O
InChIKey ZXERDUOLZKYMJM-ZWECCWDJSA-N

Biological Activity

Obeticholic Acid (INT-747) is a potent, selective farnesoid X receptor (FXR) agonist with an EC50 of 99 nM. Upon activation of FXR, it modulates gene networks involved in bile acid transport and hepatic lipid metabolism. Furthermore, Obeticholic Acid inhibits autophagy and suppresses pro-inflammatory pathways, thereby reducing hepatic steatosis and fibrotic phenotypes in cellular and tissue models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 84 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Pellicciari R, et al. J Med Chem. 2002;45(17):3569-72.

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Note: Technical data last updated: Sep 1, 2026.