CAS No. 459789-99-2
Batch:
Purity:99.77
Chemical Structure
Check the
Obeticholic Acid (INT-747)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid | |
|---|---|---|
| CAS Number | 459789-99-2 | |
| Molecular Formula |
C26H44O4 |
|
| Molecular Weight (MW) | 420.63 | |
| SMILES | CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O | |
| InChIKey | ZXERDUOLZKYMJM-ZWECCWDJSA-N |
Obeticholic Acid (INT-747) is a potent, selective farnesoid X receptor (FXR) agonist with an EC50 of 99 nM. Upon activation of FXR, it modulates gene networks involved in bile acid transport and hepatic lipid metabolism. Furthermore, Obeticholic Acid inhibits autophagy and suppresses pro-inflammatory pathways, thereby reducing hepatic steatosis and fibrotic phenotypes in cellular and tissue models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 84 mg/mL |
| Water | Insoluble |
| DMSO |
84 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 84 mg/mL |
| Water | Insoluble |
| DMSO |
84 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 84 mg/mL |
| Water | Insoluble |
| DMSO |
84 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 84 mg/mL |
| Water | Insoluble |
| DMSO |
84 mg/mL
(199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 84 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Obeticholic Acid (INT-747) Clinical Trials
- Obeticholic Acid (INT-747) Solubility in DMSO
- Obeticholic Acid (INT-747) Stock Solution
- Obeticholic Acid (INT-747) Storage
- Obeticholic Acid (INT-747) Stability
- Obeticholic Acid (INT-747) Molecular Weight
- Obeticholic Acid (INT-747) SMILES
- Obeticholic Acid (INT-747) Chemical Structure (2D and 3D)
- Obeticholic Acid (INT-747) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.