CAS No. 19916-73-5
| IUPAC Name | 6-phenylmethoxy-7H-purin-2-amine | |
|---|---|---|
| CAS Number | 19916-73-5 | |
| Molecular Formula |
C12H11N5O |
|
| Molecular Weight (MW) | 241.25 | |
| SMILES | C1=CC=C(C=C1)COC2=NC(=NC3=C2NC=N3)N | |
| InChIKey | KRWMERLEINMZFT-UHFFFAOYSA-N |
O6-Benzylguanine is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. By depleting AGT, a key DNA repair protein, O6-Benzylguanine inhibits the repair of O6-alkylguanine adducts formed by DNA damaging compounds. This inactivation impairs DNA repair pathways and significantly enhances the sensitivity of cancer cells to alkylating chemotherapy agents, including temozolomide and carmustine, ultimately promoting DNA double-strand breaks and apoptotic cell death. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
48 mg/mL
(198.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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